Astatine-211 labeling: a study towards automatic production of astatinated antibodies

• Targeted alpha therapy is especially interesting for therapy of microscopic cancer tumors due to short path length and high linear energy transfer of the alpha particles. One of the most promising nuclides for targeted alpha therapy is At-211. To facilitate larger clinical studies using At-211, the current manual synthesis of radiolabeled antibodies would benefit from being transferred into an automated method. In this work, successful modifications of the manual synthesis have been performed in order to adapt it to automation. The automatic synthesis has also been tested using the modified synthesis method.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)

Nyckelord

At-211

Labeling

Immunoconjugates

Antibodies

Radiopharmaceutical module

AT-211-LABELED ANTIBODIES

ALPHA-RADIOIMMUNOTHERAPY

NUDE-MICE

CANCER

Chemistry

Analytical

Chemistry

Inorganic & Nuclear

Technology

CANCER

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