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Genetic association...
Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization
- Article/chapterEnglish2014
Publisher, publication year, extent ...
-
2014-06-22
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Nature Publishing Group,2014
Numbers
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LIBRIS-ID:oai:gup.ub.gu.se/214196
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https://gup.ub.gu.se/publication/214196URI
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https://doi.org/10.1038/ng.3014DOI
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https://lup.lub.lu.se/record/4527138URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-230151URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:129508646URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:du-21327URI
Supplementary language notes
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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The QT interval, an electrocardiographic measure reflecting myocardial repolarization, is a heritable trait. QT prolongation is a risk factor for ventricular arrhythmias and sudden cardiac death (SCD) and could indicate the presence of the potentially lethal mendelian long-QT syndrome (LQTS). Using a genome-wide association and replication study in up to 100,000 individuals, we identified 35 common variant loci associated with QT interval that collectively explain ∼ 8-10% of QT-interval variation and highlight the importance of calcium regulation in myocardial repolarization. Rare variant analysis of 6 new QT interval-associated loci in 298 unrelated probands with LQTS identified coding variants not found in controls but of uncertain causality and therefore requiring validation. Several newly identified loci encode proteins that physically interact with other recognized repolarization proteins. Our integration of common variant association, expression and orthogonal protein-protein interaction screens provides new insights into cardiac electrophysiology and identifies new candidate genes for ventricular arrhythmias, LQTS and SCD. © 2014 Nature America, Inc.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Lind, LarsUppsala universitet,Kardiovaskulär epidemiologi(Swepub:uu)larslind
(author)
-
Crotti, L.
(author)
-
van der Harst, P.
(author)
-
Munroe, P. B.
(author)
-
Koopmann, T. T.
(author)
-
Sotoodehnia, N.
(author)
-
Rossin, E. J.
(author)
-
Morley, M.Uppsala universitet,Institutionen för medicinska vetenskaper
(author)
-
Wang, X.
(author)
-
Johnson, A. D.
(author)
-
Lundby, A.
(author)
-
Gudbjartsson, D. F.
(author)
-
Noseworthy, P. A.
(author)
-
Eijgelsheim, M.
(author)
-
Bradford, Y.
(author)
-
Tarasov, K. V.
(author)
-
Dörr, M.
(author)
-
Müller-Nurasyid, M.
(author)
-
Lahtinen, A. M.
(author)
-
Nolte, I. M.
(author)
-
Smith, A. V.
(author)
-
Bis, J. C.
(author)
-
Isaacs, A.
(author)
-
Newhouse, S. J.
(author)
-
Evans, D. S.
(author)
-
Post, W. S.
(author)
-
Waggott, D.
(author)
-
Lyytikäinen, L. P.
(author)
-
Hicks, A. A.
(author)
-
Eisele, L.
(author)
-
Ellinghaus, D.
(author)
-
Hayward, C.
(author)
-
Navarro, P.
(author)
-
Ulivi, S.
(author)
-
Tanaka, T.
(author)
-
Tester, D. J.
(author)
-
Chatel, S.
(author)
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Gustafsson, StefanUppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)stegu732
(author)
-
Kumari, M.
(author)
-
Morris, R. W.
(author)
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Torinsson Naluai, Åsa,1968Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik,Institute of Biomedicine, Department of Medical and Clinical Genetics(Swepub:gu)xnalas
(author)
-
Padmanabhan, S.
(author)
-
Kluttig, A.
(author)
-
Strohmer, B.Uppsala universitet,Institutionen för medicinska vetenskaper
(author)
-
Panayiotou, A. G.
(author)
-
Torres, M.
(author)
-
Knoflach, M.
(author)
-
Ärnlöv, JohanHögskolan Dalarna,Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab,Medicinsk vetenskap(Swepub:du)jan
(author)
-
Slowikowski, K.
(author)
-
Raychaudhuri, S.
(author)
-
Kumar, R. D.
(author)
-
Harris, T. B.
(author)
-
Launer, L. J.
(author)
-
Shuldiner, A. R.
(author)
-
Alonso, A.
(author)
-
Bader, J. S.
(author)
-
Ehret, G.
(author)
-
Huang, H.Uppsala universitet,Institutionen för medicinska vetenskaper
(author)
-
Kao, W. H. L.
(author)
-
Strait, J. B.
(author)
-
Macfarlane, P. W.
(author)
-
Brown, M.
(author)
-
Caulfield, M. J.
(author)
-
Samani, N. J.
(author)
-
Kronenberg, F.
(author)
-
Willeit, J.
(author)
-
Smith, GustavLund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)med-gvs
(author)
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Greiser, K. H.
(author)
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Zu Schwabedissen, H. M.
(author)
-
Werdan, K.
(author)
-
Carella, M.
(author)
-
Zelante, L.
(author)
-
Heckbert, S. R.
(author)
-
Psaty, B. M.
(author)
-
Rotter, J. I.
(author)
-
Kolcic, I.
(author)
-
Polašek, O.
(author)
-
Wright, A. F.
(author)
-
Griffin, M.
(author)
-
Daly, M. J.
(author)
-
Arnar, D. O.
(author)
-
Hólm, H.
(author)
-
Thorsteinsdottir, U.
(author)
-
Denny, J. C.
(author)
-
Roden, D. M.
(author)
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Zuvich, R. L.
(author)
-
Emilsson, V.
(author)
-
Plump, A. S.
(author)
-
Larson, M. G.
(author)
-
O'Donnell, C. J.
(author)
-
Yin, X.
(author)
-
Bobbo, M.
(author)
-
D'Adamo, A. P.
(author)
-
Iorio, A.
(author)
-
Sinagra, G.
(author)
-
Carracedo, A.
(author)
-
Cummings, S. R.
(author)
-
Nalls, M. A.
(author)
-
Jula, A.
(author)
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Kontula, K. K.
(author)
-
Marjamaa, A.
(author)
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Oikarinen, L.
(author)
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Perola, M.
(author)
-
Porthan, K.Uppsala universitet,Institutionen för medicinska vetenskaper
(author)
-
Erbel, R.
(author)
-
Hoffmann, P.
(author)
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Jöckel, K. H.
(author)
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Kälsch, H.
(author)
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Nöthen, M. M.
(author)
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Den Hoed, M.
(author)
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Loos, R. J. F.
(author)
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Thelle, Dag,1942Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine(Swepub:gu)xtheda
(author)
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Gieger, C.
(author)
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Meitinger, T.
(author)
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Perz, S.
(author)
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Peters, A.
(author)
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Prucha, H.
(author)
-
Sinner, M. F.
(author)
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Waldenberger, M.
(author)
-
de Boer, R. A.
(author)
-
Franke, L.
(author)
-
Van Der Vleuten, P. A.
(author)
-
Beckmann, B. M.
(author)
-
Martens, E.
(author)
-
Bardai, A.
(author)
-
Hofman, N.
(author)
-
Wilde, A. A. M.
(author)
-
Behr, E. R.
(author)
-
Dalageorgou, C.
(author)
-
Giudicessi, J. R.
(author)
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Medeiros-Domingo, A.
(author)
-
Barc, J.
(author)
-
Kyndt, F.
(author)
-
Probst, V.
(author)
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Ghidoni, A.Uppsala universitet,Institutionen för medicinska vetenskaper
(author)
-
Insolia, R.
(author)
-
Hamilton, R. M.
(author)
-
Scherer, S. W.
(author)
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Brandimarto, J.
(author)
-
Margulies, K.
(author)
-
Moravec, C. E.
(author)
-
Del Greco M, F.
(author)
-
Fuchsberger, C.
(author)
-
O'Connell, J. R.
(author)
-
Lee, W. K.
(author)
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Watt, G. C. M.
(author)
-
Campbell, H.
(author)
-
Wild, S. H.
(author)
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El Mokhtari, N. E.
(author)
-
Frey, N.
(author)
-
Asselbergs, F. W.
(author)
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Leach, I. M.
(author)
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Navis, G.
(author)
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Van Den Berg, M. P.
(author)
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van Veldhuisen, D. J.
(author)
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Kellis, M.
(author)
-
Krijthe, B. P.
(author)
-
Franco, O. H.
(author)
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Hofman, A.Uppsala universitet,Institutionen för medicinska vetenskaper
(author)
-
Kors, J. A.
(author)
-
Uitterlinden, A. G.
(author)
-
Witteman, J. C. M.
(author)
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Kedenko, L.
(author)
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Lamina, C.
(author)
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Oostra, B. A.
(author)
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Abecasis, G. R.
(author)
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Lakatta, E. G.
(author)
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Mulas, A.
(author)
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Orrú, M.
(author)
-
Schlessinger, D.
(author)
-
Uda, M.
(author)
-
Markus, M. R. P.
(author)
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Völker, U.
(author)
-
Snieder, H.
(author)
-
Spector, T. D.
(author)
-
Ärnlöv, J.
(author)
-
Lind, L.
(author)
-
Sundström, J.
(author)
-
Syvänen, Ann-ChristineUppsala universitet,Molekylär medicin,Science for Life Laboratory, SciLifeLab(Swepub:uu)anncsyva
(author)
-
Kivimaki, M.
(author)
-
Kähönen, M.
(author)
-
Mononen, N.
(author)
-
Raitakari, O. T.
(author)
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Viikari, J. S.
(author)
-
Adamkova, V.
(author)
-
Kiechl, S.
(author)
-
Brion, M.
(author)
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Nicolaides, A. N.
(author)
-
Paulweber, B.
(author)
-
Haerting, J.
(author)
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Dominiczak, A. F.
(author)
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Nyberg, Fredrik,1961Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine(Swepub:gu)xnybef
(author)
-
Whincup, P. H.
(author)
-
Hingorani, A. D.
(author)
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Schott, J. J.
(author)
-
Bezzina, C. R.
(author)
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Ingelsson, ErikUppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)ering425
(author)
-
Ferrucci, L.
(author)
-
Gasparini, P.
(author)
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Wilson, J. F.
(author)
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Rudan, I.
(author)
-
Franke, A.
(author)
-
Mühleisen, T. W.
(author)
-
Pramstaller, P. P.
(author)
-
Lehtimäki, T. J.
(author)
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Paterson, A. D.
(author)
-
Parsa, A.
(author)
-
Liu, Y.
(author)
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Van Duijn, C. M.
(author)
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Siscovick, D. S.
(author)
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Gudnason, V.
(author)
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Jamshidi, Y.
(author)
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Salomaa, V.
(author)
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Felix, S. B.
(author)
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Sanna, S.
(author)
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Ritchie, M. D.
(author)
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Stricker, B. H.
(author)
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Stefansson, K.
(author)
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Boyer, L. A.
(author)
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Cappola, T. P.
(author)
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Olsen, J. V.
(author)
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Lage, K.
(author)
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Schwartz, P. J.
(author)
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Kääb, S.
(author)
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Chakravarti, A.
(author)
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Ackerman, M. J.
(author)
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Pfeufer, A.
(author)
-
de Bakker, P. I. W.
(author)
-
Newton-Cheh, C.
(author)
-
Fabiola, NN
(author)
-
Uppsala universitetKardiovaskulär epidemiologi
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In:Nature Genetics: Nature Publishing Group46:8, s. 826-8361061-40361546-1718
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Nature Genetics
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University of Gothenburg
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