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Genetic association...
Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization
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Arking, D. E. (author)
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- Lind, Lars (author)
- Uppsala universitet,Kardiovaskulär epidemiologi
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Crotti, L. (author)
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show more...
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van der Harst, P. (author)
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Munroe, P. B. (author)
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Koopmann, T. T. (author)
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Sotoodehnia, N. (author)
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Rossin, E. J. (author)
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- Morley, M. (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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Wang, X. (author)
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Johnson, A. D. (author)
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Lundby, A. (author)
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Gudbjartsson, D. F. (author)
-
Noseworthy, P. A. (author)
-
Eijgelsheim, M. (author)
-
Bradford, Y. (author)
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Tarasov, K. V. (author)
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Dörr, M. (author)
-
Müller-Nurasyid, M. (author)
-
Lahtinen, A. M. (author)
-
Nolte, I. M. (author)
-
Smith, A. V. (author)
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Bis, J. C. (author)
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Isaacs, A. (author)
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Newhouse, S. J. (author)
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Evans, D. S. (author)
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Post, W. S. (author)
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Waggott, D. (author)
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Lyytikäinen, L. P. (author)
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Hicks, A. A. (author)
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Eisele, L. (author)
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Ellinghaus, D. (author)
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Hayward, C. (author)
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Navarro, P. (author)
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Ulivi, S. (author)
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Tanaka, T. (author)
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Tester, D. J. (author)
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Chatel, S. (author)
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- Gustafsson, Stefan (author)
- Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab
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Kumari, M. (author)
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Morris, R. W. (author)
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- Torinsson Naluai, Åsa, 1968 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik,Institute of Biomedicine, Department of Medical and Clinical Genetics
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Padmanabhan, S. (author)
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Kluttig, A. (author)
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- Strohmer, B. (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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Panayiotou, A. G. (author)
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Torres, M. (author)
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Knoflach, M. (author)
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- Ärnlöv, Johan (author)
- Högskolan Dalarna,Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab,Medicinsk vetenskap
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Slowikowski, K. (author)
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Raychaudhuri, S. (author)
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Kumar, R. D. (author)
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Harris, T. B. (author)
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Launer, L. J. (author)
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Shuldiner, A. R. (author)
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Alonso, A. (author)
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Bader, J. S. (author)
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Ehret, G. (author)
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- Huang, H. (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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Kao, W. H. L. (author)
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Strait, J. B. (author)
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Macfarlane, P. W. (author)
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Brown, M. (author)
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Caulfield, M. J. (author)
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Samani, N. J. (author)
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Kronenberg, F. (author)
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Willeit, J. (author)
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- Smith, Gustav (author)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine
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Greiser, K. H. (author)
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Zu Schwabedissen, H. M. (author)
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Werdan, K. (author)
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Carella, M. (author)
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Zelante, L. (author)
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Heckbert, S. R. (author)
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Psaty, B. M. (author)
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Rotter, J. I. (author)
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Kolcic, I. (author)
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Polašek, O. (author)
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Wright, A. F. (author)
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Griffin, M. (author)
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Daly, M. J. (author)
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Arnar, D. O. (author)
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Hólm, H. (author)
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Thorsteinsdottir, U. (author)
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Denny, J. C. (author)
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Roden, D. M. (author)
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Zuvich, R. L. (author)
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Emilsson, V. (author)
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Plump, A. S. (author)
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Larson, M. G. (author)
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O'Donnell, C. J. (author)
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Yin, X. (author)
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Bobbo, M. (author)
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D'Adamo, A. P. (author)
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Iorio, A. (author)
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Sinagra, G. (author)
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Carracedo, A. (author)
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Cummings, S. R. (author)
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Nalls, M. A. (author)
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Jula, A. (author)
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Kontula, K. K. (author)
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Marjamaa, A. (author)
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Oikarinen, L. (author)
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Perola, M. (author)
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- Porthan, K. (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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Erbel, R. (author)
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Hoffmann, P. (author)
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Jöckel, K. H. (author)
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Kälsch, H. (author)
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Nöthen, M. M. (author)
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Den Hoed, M. (author)
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Loos, R. J. F. (author)
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- Thelle, Dag, 1942 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine
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Gieger, C. (author)
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Meitinger, T. (author)
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Perz, S. (author)
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Peters, A. (author)
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Prucha, H. (author)
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Sinner, M. F. (author)
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Waldenberger, M. (author)
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de Boer, R. A. (author)
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Franke, L. (author)
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Van Der Vleuten, P. A. (author)
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Beckmann, B. M. (author)
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Martens, E. (author)
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Bardai, A. (author)
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Hofman, N. (author)
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Wilde, A. A. M. (author)
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Behr, E. R. (author)
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Dalageorgou, C. (author)
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Giudicessi, J. R. (author)
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Medeiros-Domingo, A. (author)
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Barc, J. (author)
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Kyndt, F. (author)
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Probst, V. (author)
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- Ghidoni, A. (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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Insolia, R. (author)
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Hamilton, R. M. (author)
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Scherer, S. W. (author)
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Brandimarto, J. (author)
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Margulies, K. (author)
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Moravec, C. E. (author)
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Del Greco M, F. (author)
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Fuchsberger, C. (author)
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O'Connell, J. R. (author)
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Lee, W. K. (author)
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Watt, G. C. M. (author)
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Campbell, H. (author)
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Wild, S. H. (author)
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El Mokhtari, N. E. (author)
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Frey, N. (author)
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Asselbergs, F. W. (author)
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Leach, I. M. (author)
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Navis, G. (author)
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Van Den Berg, M. P. (author)
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van Veldhuisen, D. J. (author)
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Kellis, M. (author)
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Krijthe, B. P. (author)
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Franco, O. H. (author)
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- Hofman, A. (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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Kors, J. A. (author)
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Uitterlinden, A. G. (author)
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Witteman, J. C. M. (author)
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Kedenko, L. (author)
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Lamina, C. (author)
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Oostra, B. A. (author)
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Abecasis, G. R. (author)
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Lakatta, E. G. (author)
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Mulas, A. (author)
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Orrú, M. (author)
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Schlessinger, D. (author)
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Uda, M. (author)
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Markus, M. R. P. (author)
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Völker, U. (author)
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Snieder, H. (author)
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Spector, T. D. (author)
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Ärnlöv, J. (author)
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Lind, L. (author)
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Sundström, J. (author)
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- Syvänen, Ann-Christine (author)
- Uppsala universitet,Molekylär medicin,Science for Life Laboratory, SciLifeLab
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Kivimaki, M. (author)
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Kähönen, M. (author)
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Mononen, N. (author)
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Raitakari, O. T. (author)
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Viikari, J. S. (author)
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Adamkova, V. (author)
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Kiechl, S. (author)
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Brion, M. (author)
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Nicolaides, A. N. (author)
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Paulweber, B. (author)
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Haerting, J. (author)
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Dominiczak, A. F. (author)
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- Nyberg, Fredrik, 1961 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine
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Whincup, P. H. (author)
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Hingorani, A. D. (author)
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Schott, J. J. (author)
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Bezzina, C. R. (author)
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- Ingelsson, Erik (author)
- Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab
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Ferrucci, L. (author)
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Gasparini, P. (author)
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Wilson, J. F. (author)
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Rudan, I. (author)
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Franke, A. (author)
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Mühleisen, T. W. (author)
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Pramstaller, P. P. (author)
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Lehtimäki, T. J. (author)
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Paterson, A. D. (author)
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Parsa, A. (author)
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Liu, Y. (author)
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Van Duijn, C. M. (author)
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Siscovick, D. S. (author)
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Gudnason, V. (author)
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Jamshidi, Y. (author)
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Salomaa, V. (author)
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Felix, S. B. (author)
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Sanna, S. (author)
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Ritchie, M. D. (author)
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Stricker, B. H. (author)
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Stefansson, K. (author)
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Boyer, L. A. (author)
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Cappola, T. P. (author)
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Olsen, J. V. (author)
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Lage, K. (author)
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Schwartz, P. J. (author)
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Kääb, S. (author)
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Chakravarti, A. (author)
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Ackerman, M. J. (author)
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Pfeufer, A. (author)
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de Bakker, P. I. W. (author)
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Newton-Cheh, C. (author)
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Fabiola, NN (author)
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(creator_code:org_t)
- 2014-06-22
- 2014
- English.
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In: Nature Genetics. - : Nature Publishing Group. - 1061-4036 .- 1546-1718. ; 46:8, s. 826-836
- Related links:
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http://www.ncbi.nlm....
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http://dx.doi.org/10...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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https://urn.kb.se/re...
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Abstract
Subject headings
Close
- The QT interval, an electrocardiographic measure reflecting myocardial repolarization, is a heritable trait. QT prolongation is a risk factor for ventricular arrhythmias and sudden cardiac death (SCD) and could indicate the presence of the potentially lethal mendelian long-QT syndrome (LQTS). Using a genome-wide association and replication study in up to 100,000 individuals, we identified 35 common variant loci associated with QT interval that collectively explain ∼ 8-10% of QT-interval variation and highlight the importance of calcium regulation in myocardial repolarization. Rare variant analysis of 6 new QT interval-associated loci in 298 unrelated probands with LQTS identified coding variants not found in controls but of uncertain causality and therefore requiring validation. Several newly identified loci encode proteins that physically interact with other recognized repolarization proteins. Our integration of common variant association, expression and orthogonal protein-protein interaction screens provides new insights into cardiac electrophysiology and identifies new candidate genes for ventricular arrhythmias, LQTS and SCD. © 2014 Nature America, Inc.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- calcium
- protein
- adult
- article
- calcium signaling
- cardiovascular risk
- controlled study
- female
- gene expression
- genetic association
- genetic variability
- genotype
- heart electrophysiology
- heart repolarization
- heart ventricle arrhythmia
- human
- long QT syndrome
- major clinical study
- male
- mutational analysis
- phenotype
- priority journal
- protein protein interaction
- QT interval
- QT prolongation
- replication study
- single nucleotide polymorphism
- sudden cardiac death
- Hälsa och välfärd
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Arking, D. E.
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Lind, Lars
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Crotti, L.
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van der Harst, P ...
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Munroe, P. B.
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Koopmann, T. T.
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show more...
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Sotoodehnia, N.
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Rossin, E. J.
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Morley, M.
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Wang, X.
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Johnson, A. D.
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Lundby, A.
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Gudbjartsson, D. ...
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Noseworthy, P. A ...
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Eijgelsheim, M.
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Bradford, Y.
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Tarasov, K. V.
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Dörr, M.
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Müller-Nurasyid, ...
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Lahtinen, A. M.
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Nolte, I. M.
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Smith, A. V.
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Bis, J. C.
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Isaacs, A.
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Newhouse, S. J.
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Evans, D. S.
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Post, W. S.
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Waggott, D.
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Lyytikäinen, L. ...
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Hicks, A. A.
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Eisele, L.
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Ellinghaus, D.
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Hayward, C.
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Navarro, P.
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Ulivi, S.
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Tanaka, T.
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Tester, D. J.
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Chatel, S.
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Gustafsson, Stef ...
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Kumari, M.
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Morris, R. W.
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Torinsson Naluai ...
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Padmanabhan, S.
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Kluttig, A.
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Strohmer, B.
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Panayiotou, A. G ...
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Torres, M.
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Knoflach, M.
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Ärnlöv, Johan
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Slowikowski, K.
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Raychaudhuri, S.
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Kumar, R. D.
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Harris, T. B.
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Launer, L. J.
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Shuldiner, A. R.
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Alonso, A.
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Bader, J. S.
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Ehret, G.
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Huang, H.
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Kao, W. H. L.
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Strait, J. B.
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Macfarlane, P. W ...
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Brown, M.
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Caulfield, M. J.
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Samani, N. J.
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Kronenberg, F.
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Willeit, J.
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Smith, Gustav
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Greiser, K. H.
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Zu Schwabedissen ...
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Werdan, K.
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Carella, M.
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Zelante, L.
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Heckbert, S. R.
-
Psaty, B. M.
-
Rotter, J. I.
-
Kolcic, I.
-
Polašek, O.
-
Wright, A. F.
-
Griffin, M.
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Daly, M. J.
-
Arnar, D. O.
-
Hólm, H.
-
Thorsteinsdottir ...
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Denny, J. C.
-
Roden, D. M.
-
Zuvich, R. L.
-
Emilsson, V.
-
Plump, A. S.
-
Larson, M. G.
-
O'Donnell, C. J.
-
Yin, X.
-
Bobbo, M.
-
D'Adamo, A. P.
-
Iorio, A.
-
Sinagra, G.
-
Carracedo, A.
-
Cummings, S. R.
-
Nalls, M. A.
-
Jula, A.
-
Kontula, K. K.
-
Marjamaa, A.
-
Oikarinen, L.
-
Perola, M.
-
Porthan, K.
-
Erbel, R.
-
Hoffmann, P.
-
Jöckel, K. H.
-
Kälsch, H.
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Nöthen, M. M.
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Den Hoed, M.
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Loos, R. J. F.
-
Thelle, Dag, 194 ...
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Gieger, C.
-
Meitinger, T.
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Perz, S.
-
Peters, A.
-
Prucha, H.
-
Sinner, M. F.
-
Waldenberger, M.
-
de Boer, R. A.
-
Franke, L.
-
Van Der Vleuten, ...
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Beckmann, B. M.
-
Martens, E.
-
Bardai, A.
-
Hofman, N.
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Wilde, A. A. M.
-
Behr, E. R.
-
Dalageorgou, C.
-
Giudicessi, J. R ...
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Medeiros-Domingo ...
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Barc, J.
-
Kyndt, F.
-
Probst, V.
-
Ghidoni, A.
-
Insolia, R.
-
Hamilton, R. M.
-
Scherer, S. W.
-
Brandimarto, J.
-
Margulies, K.
-
Moravec, C. E.
-
Del Greco M, F.
-
Fuchsberger, C.
-
O'Connell, J. R.
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Lee, W. K.
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Watt, G. C. M.
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Campbell, H.
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Wild, S. H.
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El Mokhtari, N. ...
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Frey, N.
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Asselbergs, F. W ...
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Leach, I. M.
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Navis, G.
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Van Den Berg, M. ...
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van Veldhuisen, ...
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Kellis, M.
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Krijthe, B. P.
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Franco, O. H.
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Hofman, A.
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Kors, J. A.
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Uitterlinden, A. ...
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Witteman, J. C. ...
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Kedenko, L.
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Lamina, C.
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Oostra, B. A.
-
Abecasis, G. R.
-
Lakatta, E. G.
-
Mulas, A.
-
Orrú, M.
-
Schlessinger, D.
-
Uda, M.
-
Markus, M. R. P.
-
Völker, U.
-
Snieder, H.
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Spector, T. D.
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Ärnlöv, J.
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Lind, L.
-
Sundström, J.
-
Syvänen, Ann-Chr ...
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Kivimaki, M.
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Kähönen, M.
-
Mononen, N.
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Raitakari, O. T.
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Viikari, J. S.
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Adamkova, V.
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Kiechl, S.
-
Brion, M.
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Nicolaides, A. N ...
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Paulweber, B.
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Haerting, J.
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Dominiczak, A. F ...
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Nyberg, Fredrik, ...
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Whincup, P. H.
-
Hingorani, A. D.
-
Schott, J. J.
-
Bezzina, C. R.
-
Ingelsson, Erik
-
Ferrucci, L.
-
Gasparini, P.
-
Wilson, J. F.
-
Rudan, I.
-
Franke, A.
-
Mühleisen, T. W.
-
Pramstaller, P. ...
-
Lehtimäki, T. J.
-
Paterson, A. D.
-
Parsa, A.
-
Liu, Y.
-
Van Duijn, C. M.
-
Siscovick, D. S.
-
Gudnason, V.
-
Jamshidi, Y.
-
Salomaa, V.
-
Felix, S. B.
-
Sanna, S.
-
Ritchie, M. D.
-
Stricker, B. H.
-
Stefansson, K.
-
Boyer, L. A.
-
Cappola, T. P.
-
Olsen, J. V.
-
Lage, K.
-
Schwartz, P. J.
-
Kääb, S.
-
Chakravarti, A.
-
Ackerman, M. J.
-
Pfeufer, A.
-
de Bakker, P. I. ...
-
Newton-Cheh, C.
-
Fabiola, NN
-
show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
- Articles in the publication
-
Nature Genetics
- By the university
-
University of Gothenburg
-
Lund University
-
Uppsala University
-
Karolinska Institutet
-
Högskolan Dalarna