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  • Caroli, A. (author)

Mild cognitive impairment with suspected nonamyloid pathology (SNAP) Prediction of progression

  • Article/chapterEnglish2015

Publisher, publication year, extent ...

  • 2015-01-07
  • Ovid Technologies (Wolters Kluwer Health),2015

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  • LIBRIS-ID:oai:gup.ub.gu.se/214286
  • https://gup.ub.gu.se/publication/214286URI
  • https://doi.org/10.1212/wnl.0000000000001209DOI

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  • Language:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

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  • Objectives:The aim of this study was to investigate predictors of progressive cognitive deterioration in patients with suspected non-Alzheimer disease pathology (SNAP) and mild cognitive impairment (MCI).Methods:We measured markers of amyloid pathology (CSF -amyloid 42) and neurodegeneration (hippocampal volume on MRI and cortical metabolism on [F-18]-fluorodeoxyglucose-PET) in 201 patients with MCI clinically followed for up to 6 years to detect progressive cognitive deterioration. We categorized patients with MCI as A+/A- and N+/N- based on presence/absence of amyloid pathology and neurodegeneration. SNAPs were A-N+ cases.Results:The proportion of progressors was 11% (8/41), 34% (14/41), 56% (19/34), and 71% (60/85) in A-N-, A+N-, SNAP, and A+N+, respectively; the proportion of APOE epsilon 4 carriers was 29%, 70%, 31%, and 71%, respectively, with the SNAP group featuring a significantly different proportion than both A+N- and A+N+ groups (p 0.005). Hypometabolism in SNAP patients was comparable to A+N+ patients (p = 0.154), while hippocampal atrophy was more severe in SNAP patients (p = 0.002). Compared with A-N-, SNAP and A+N+ patients had significant risk of progressive cognitive deterioration (hazard ratio = 2.7 and 3.8, p = 0.016 and p < 0.001), while A+N- patients did not (hazard ratio = 1.13, p = 0.771). In A+N- and A+N+ groups, none of the biomarkers predicted time to progression. In the SNAP group, lower time to progression was correlated with greater hypometabolism (r = 0.42, p = 0.073).Conclusions:Our findings support the notion that patients with SNAP MCI feature a specific risk progression profile.

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  • Prestia, A. (author)
  • Galluzzi, S. (author)
  • Ferrari, C. (author)
  • van der Flier, W. M. (author)
  • Ossenkoppele, R. (author)
  • Van Berckel, B. (author)
  • Barkhof, F. (author)
  • Teunissen, C. (author)
  • Wall, A. E. (author)
  • Carter, S. F. (author)
  • Schöll, Michael,1980Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation(Swepub:gu)xschom (author)
  • Choo, I. H. (author)
  • Grimmer, T. (author)
  • Redolfi, A. (author)
  • Nordberg, A. (author)
  • Scheltens, P. (author)
  • Drzezga, A. (author)
  • Frisoni, G. B. (author)
  • Göteborgs universitetInstitutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering (creator_code:org_t)

Related titles

  • In:Neurology: Ovid Technologies (Wolters Kluwer Health)84:5, s. 508-5150028-38781526-632X

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