SwePub
Sök i LIBRIS databas

  Extended search

onr:"swepub:oai:gup.ub.gu.se/214495"
 

Search: onr:"swepub:oai:gup.ub.gu.se/214495" > DNA Damage Primes t...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist
  • Härtlova, AnettaUmeå universitet,Molekylär Infektionsmedicin, Sverige (MIMS),Institutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet),Umeå Centre for Microbial Research (UCMR) (author)

DNA Damage Primes the Type I Interferon System via the Cytosolic DNA Sensor STING to Promote Anti-Microbial Innate Immunity.

  • Article/chapterEnglish2015

Publisher, publication year, extent ...

  • Elsevier BV,2015

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/214495
  • https://gup.ub.gu.se/publication/214495URI
  • https://doi.org/10.1016/j.immuni.2015.01.012DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-101396URI

Supplementary language notes

  • Language:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Dysfunction in Ataxia-telangiectasia mutated (ATM), a central component of the DNA repair machinery, results in Ataxia Telangiectasia (AT), a cancer-prone disease with a variety of inflammatory manifestations. By analyzing AT patient samples and Atm(-/-) mice, we found that unrepaired DNA lesions induce type I interferons (IFNs), resulting in enhanced anti-viral and anti-bacterial responses in Atm(-/-) mice. Priming of the type I interferon system by DNA damage involved release of DNA into the cytoplasm where it activated the cytosolic DNA sensing STING-mediated pathway, which in turn enhanced responses to innate stimuli by activating the expression of Toll-like receptors, RIG-I-like receptors, cytoplasmic DNA sensors, and their downstream signaling partners. This study provides a potential explanation for the inflammatory phenotype of AT patients and establishes damaged DNA as a cell intrinsic danger signal that primes the innate immune system for a rapid and amplified response to microbial and environmental threats.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Erttmann, Saskia F.Umeå universitet,Molekylär Infektionsmedicin, Sverige (MIMS),Institutionen för molekylärbiologi (Medicinska fakulteten),Umeå Centre for Microbial Research (UCMR)(Swepub:umu)saer0053 (author)
  • Raffi, Faizal AmUmeå universitet,Molekylär Infektionsmedicin, Sverige (MIMS),Umeå Centre for Microbial Research (UCMR),Institutionen för molekylärbiologi (Medicinska fakulteten) (author)
  • Schmalz, Anja M.Umeå universitet,Molekylär Infektionsmedicin, Sverige (MIMS),Umeå Centre for Microbial Research (UCMR),Institutionen för molekylärbiologi (Medicinska fakulteten)(Swepub:umu)ansc0060 (author)
  • Resch, UlrikeUmeå universitet,Molekylär Infektionsmedicin, Sverige (MIMS),Umeå Centre for Microbial Research (UCMR),Institutionen för molekylärbiologi (Medicinska fakulteten) (author)
  • Anugula, SharathUmeå universitet,Molekylär Infektionsmedicin, Sverige (MIMS),Umeå Centre for Microbial Research (UCMR),Institutionen för molekylärbiologi (Medicinska fakulteten) (author)
  • Lienenklaus, Stefan (author)
  • Nilsson, Lisa M,1976Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center(Swepub:gu)xnilis (author)
  • Kröger, Andrea (author)
  • Nilsson, Jonas A,1971Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center(Swepub:gu)xnijon (author)
  • Ek, Torben (author)
  • Weiss, Siegfried (author)
  • Gekara, Nelson O.Umeå universitet,Molekylär Infektionsmedicin, Sverige (MIMS)(Swepub:umu)fepe0003 (author)
  • Umeå universitetMolekylär Infektionsmedicin, Sverige (MIMS) (creator_code:org_t)

Related titles

  • In:Immunity: Elsevier BV42:2, s. 332-431097-41801074-7613

Internet link

Find in a library

  • Immunity (Search for host publication in LIBRIS)

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view