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Brain Amyloid-Beta ...
Brain Amyloid-Beta Fragment Signatures in Pathological Ageing and Alzheimer's Disease by Hybrid Immunoprecipitation Mass Spectrometry
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- Portelius, Erik, 1977 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Lashley, T. (author)
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- Westerlund, Anna, 1981 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Persson, Rita, 1951 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Fox, N. C. (author)
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- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Revesz, T. (author)
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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(creator_code:org_t)
- 2015-01-13
- 2015
- English.
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In: Neurodegenerative Diseases. - : S. Karger AG. - 1660-2854 .- 1660-2862. ; 15:1, s. 50-57
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Background: Senile plaques in Alzheimer's disease (AD) are composed of amyloid-beta (A beta) especially N-truncated forms including A beta(4-42). These are thought to be neurotoxic. However, individuals may live for decades with biomarker evidence of cerebral beta-amyloidosis (positive amyloid PET imaging and/or low cerebrospinal fluid levels of the 42 amino acid form of A beta) without cognitive impairment. This condition may be termed pathological ageing (PA). Objective: To investigate whether there is a difference in the cerebral A beta fragment pattern in brain specimens from non-demented (PA) and demented (AD) individuals expressing the full neuropathological triad of AD (senile plaques, neurofibrillary tangles and neurodegeneration). Methods: We extracted A beta using formic acid and hybrid (6E10 and 4G8) immunoprecipitation from fresh-frozen temporal cortex tissue of 6 elderly individuals (mean age +/- SD:89 +/- 3.5 years) with PA and 10 patients with AD (mean age +/- SD: 72 +/- 8.5 years). The full spectrum of A beta peptides was determined by matrix-assisted laser desorption ionization time-of-flight mass spectrometry. Results: AD patients had generally more N-terminally truncated and pyroglutamate-modified A beta than PA patients, whereas PA patients had on average more A beta(1-40) than AD patients. Conclusion: Senile plaques in AD may have an AB fragment composition distinct from PA with more N-terminally and pyroglutamate-modified A beta peptides that may be linked to neurotoxicity. (C) 2015 S. Karger AG, Basel
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- Alzheimer's disease
- Pathological ageing
- Amyloid precursor protein
- Amyloid-beta
- Brain
- CEREBROSPINAL-FLUID
- BIOMARKER CHANGES
- PEPTIDES
- PROTEIN
- DEMENTIA
- CASCADE
- ONSET
- Clinical Neurology
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Portelius, Erik, ...
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Lashley, T.
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Westerlund, Anna ...
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Persson, Rita, 1 ...
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Fox, N. C.
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Blennow, Kaj, 19 ...
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show more...
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Revesz, T.
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Zetterberg, Henr ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Neurodegenerativ ...
- By the university
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University of Gothenburg