A study on the specificity of the association between hippocampal volume and delayed primacy performance in cognitively intact elderly individuals.

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Bruno, Davide (author)

A study on the specificity of the association between hippocampal volume and delayed primacy performance in cognitively intact elderly individuals.

Article/chapterEnglish2015

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Elsevier BV,2015

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LIBRIS-ID:oai:gup.ub.gu.se/214942
https://gup.ub.gu.se/publication/214942URI
https://doi.org/10.1016/j.neuropsychologia.2015.01.025DOI

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Language:English

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Delayed recall at the primacy position (first few items on a list) has been shown to predict cognitive decline in cognitively intact elderly participants, with poorer delayed primacy performance associated with more pronounced generalized cognitive decline during follow-up. We have previously suggested that this association is due to delayed primacy performance indexing memory consolidation, which in turn is thought to depend upon hippocampal function. Here, we test the hypothesis that hippocampal size is associated with delayed primacy performance in cognitively intact elderly individuals. Data were analyzed from a group (N=81) of cognitively intact participants, aged 60 or above. Serial position performance was measured with the Buschke selective reminding test (BSRT). Hippocampal size was automatically measured via MRI, and unbiased voxel-based analyses were also conducted to explore further regional specificity of memory performance. We conducted regression analyses of hippocampus volumes on serial position performance; other predictors included age, family history of Alzheimer's disease (AD), APOE ε4 status, education, and total intracranial volume. Our results collectively suggest that there is a preferential association between hippocampal volume and delayed primacy performance. These findings are consistent with the hypothesis that delayed primacy consolidation is associated with hippocampal size, and shed light on the relationship between delayed primacy performance and generalized cognitive decline in cognitively intact individuals, suggesting that delayed primacy consolidation may serve as a sensitive marker of hippocampal health in these individuals.

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Grothe, Michel J (author)
Nierenberg, Jay (author)
Zetterberg, Henrik,1973Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xzethe (author)
Blennow, Kaj,1958Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xbleka (author)
Teipel, Stefan J (author)
Pomara, Nunzio (author)
Göteborgs universitetInstitutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi (creator_code:org_t)

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In:Neuropsychologia: Elsevier BV69, s. 1-81873-35140028-3932

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By the author/editor: Bruno, Davide; Grothe, Michel J; Nierenberg, Jay; Zetterberg, Henr ...; Blennow, Kaj, 19 ...; Teipel, Stefan J; show more...; Pomara, Nunzio; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Neurosciences

Articles in the publication: Neuropsychologia

By the university: University of Gothenburg

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