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Quantification of mutant huntingtin protein in cerebrospinal fluid from Huntington's disease patients.

Wild, Edward J (author)
Boggio, Roberto (author)
Langbehn, Douglas (author)
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Robertson, Nicola (author)
Haider, Salman (author)
Miller, James R C (author)
Zetterberg, Henrik, 1973 (author)
Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Leavitt, Blair R (author)
Kuhn, Rainer (author)
Tabrizi, Sarah J (author)
Macdonald, Douglas (author)
Weiss, Andreas (author)
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 (creator_code:org_t)
2015
2015
English.
In: The Journal of clinical investigation. - 1558-8238. ; 125:5, s. 1979-1986
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Quantification of disease-associated proteins in the cerebrospinal fluid (CSF) has been critical for the study and treatment of several neurodegenerative disorders; however, mutant huntingtin protein (mHTT), the cause of Huntington's disease (HD), is at very low levels in CSF and, to our knowledge, has never been measured previously.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Neurosciences (hsv//eng)

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