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Characterization of...
Characterization of oral immune cells in birch pollen-allergic patients: impact of the oral allergy syndrome and sublingual allergen immunotherapy on antigen-presenting cells
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Mascarell, L. (author)
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- Rak, Sabina, 1945 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research
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Worm, M. (author)
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Melac, M. (author)
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Soulie, S. (author)
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Lescaille, G. (author)
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Lemoine, F. (author)
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Jospin, F. (author)
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Paul, S. (author)
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Caplier, L. (author)
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- Hasséus, Bengt, 1955 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för odontologi,Institute of Odontology
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Bjorhn, C. (author)
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Zeldin, R. K. (author)
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Baron-Bodo, V. (author)
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Moingeon, P. (author)
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(creator_code:org_t)
- 2015-03-26
- 2015
- English.
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In: Allergy. - : Wiley. - 0105-4538. ; 70:4, s. 408-419
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https://doi.org/10.1...
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Abstract
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- Background: A detailed characterization of human oral immune cells is needed to better understand local mechanisms associated with allergen capture following oral exposure. Methods: Oral immune cells were characterized by immunohistology and immunofluorescence in biopsies obtained from three healthy individuals and 23 birch pollen-allergic patients with/without oral allergy syndrome (OAS), at baseline and after 5 months of sublingual allergen immunotherapy (AIT). Results: Similar cell subsets (i.e., dendritic cells, mast cells, and T lymphocytes) were detected in oral tissues from healthy and birch pollen-allergic individuals. CD207(+) Langerhans cells (LCs) and CD11c(+) myeloid dendritic cells (DCs) were found in both the epithelium and the papillary layer of the Lamina propria (LP), whereas CD68(+) macrophages, CD117(+) mast cells, and CD4(+)/CD8(+) T cells were rather located in both the papillary and reticular layers of the LP. Patterns of oral immune cells were identical in patients with/without OAS, except lower numbers of CD207(+) LCs found in oral tissues from patients with OAS, when compared to OAS(-) patients (P < 0.05). A 5-month sublingual AIT had a limited impact on oral immune cells, with only a significant increase in IgE(+) cells in patients from the active group. Colocalization experiments confirmed that such IgE-expressing cells mostly encompass CD68(+) macrophages located in the LP, and to a lesser extent CD207(+) LCs in the epithelium. Conclusion: Two cell subsets contribute to antigen/allergen uptake in human oral tissues, including (i) CD207(+) LCs possibly involved in the physiopathology of OAS and (ii) CD68(+) macrophages likely critical in allergen capture via IgE-facilitated mechanisms during sublingual AIT.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Odontologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dentistry (hsv//eng)
Keyword
- birch allergy
- IgE
- macrophages
- mucosal immunity
- sublingual allergen immunotherapy
- DENDRITIC CELLS
- T-CELLS
- EFFICACY
- TOLERANCE
- RHINOCONJUNCTIVITIS
- SAFETY
- METAANALYSIS
- MECHANISMS
- INDUCTION
- RHINITIS
- Allergy
- Immunology
Publication and Content Type
- ref (subject category)
- art (subject category)
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Allergy
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- By the author/editor
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Mascarell, L.
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Rak, Sabina, 194 ...
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Worm, M.
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Melac, M.
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Soulie, S.
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Lescaille, G.
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show more...
-
Lemoine, F.
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Jospin, F.
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Paul, S.
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Caplier, L.
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Hasséus, Bengt, ...
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Bjorhn, C.
-
Zeldin, R. K.
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Baron-Bodo, V.
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Moingeon, P.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Dentistry
- Articles in the publication
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Allergy
- By the university
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University of Gothenburg