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Blennow, Kaj,1958Gothenburg University,Göteborgs universitet,Institutionen för klinisk neurovetenskap, Sektionen för laborativ neurovetenskap,Institute of Clinical Neurosciences, Section of Experimental Neuroscience
(author)
No association between the alpha2-macroglobulin (A2M) deletion and Alzheimer's disease, and no change in A2M mRNA, protein, or protein expression.
- Article/chapterEnglish2000
Publisher, publication year, extent ...
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Springer Science and Business Media LLC,2000
Numbers
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LIBRIS-ID:oai:gup.ub.gu.se/215784
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https://gup.ub.gu.se/publication/215784URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:1940361URI
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https://doi.org/10.1007/s007020070052DOI
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https://lup.lub.lu.se/record/1297001URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-27884URI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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A polymorphism consisting of a deletion near the 5' splice site of exon 18 on the alpha2-macroglobulin (A2M) gene (A2M-2) has been suggested to be associated with Alzheimer's disease (AD) in family-based studies. We studied the A2M-2 allele together with the ApoE alleles in a large series on patients with AD (n = 449) and age-matched controls (n = 349). Neuropathologically confirmed diagnoses were available in 199 cases (94 AD and 107 control cases). We found no increase in A2M-2 genotype or allele frequencies in AD (27.5% and 14.6%) versus controls (26.4% and 14.9%). In contrast, a marked increase (p < 0.0001) in ApoE epsilon4 genotype or allele frequencies was found in AD (66.6% and 41.2%) as compared with controls (29.8% and 16.5%), suggesting sufficient statistical power in our sample. No relation was found between the A2M-2 and the ApoE epsilon4 allele. No change in A2M exon 17-18 mRNA size or sequence or A2M protein size was found in cases carrying the A2M-2 deletion, suggesting that there is no biological consequences of the A2M intronic deletion. No change in A2M protein level in cerebrospinal fluid was found in AD, suggesting that the A2M-2 allele does not effect the A2M protein expression in the brain. The lack of an association between the A2M-2 allele and AD in the present study, and the lack of abnormalities in the A2M mRNA or protein suggest that the A2M-2 allele is not associated with AD.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Ricksten, Anne,1957Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin, Avdelningen för klinisk kemi/transfusionsmedicin,Institute of Laboratory Medicine, Dept of Clinical Chemistry/Transfusion Medicine(Swepub:gu)xrican
(author)
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Prince, J A
(author)
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Brookes, A J
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Emahazion, T
(author)
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Wasslavik, CarinaGothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin, Avdelningen för klinisk kemi/transfusionsmedicin,Institute of Laboratory Medicine, Dept of Clinical Chemistry/Transfusion Medicine(Swepub:gu)xwacar
(author)
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Bogdanovic, NKarolinska Institutet
(author)
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Andreasen, NielsKarolinska Institutet
(author)
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Båtsman, S
(author)
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Marcusson, Jan,1958-Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Geriatrik,Geriatrik-LAH(Swepub:liu)janma25
(author)
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Nägga, KatarinaÖstergötlands Läns Landsting,Linköpings universitet,Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Hälsouniversitetet,Geriatrik,Geriatrik-LAH(Swepub:liu)katna61
(author)
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Wallin, Anders,1950Gothenburg University,Göteborgs universitet,Institutionen för klinisk neurovetenskap, Sektionen för laborativ neurovetenskap,Institute of Clinical Neurosciences, Section of Experimental Neuroscience(Swepub:gu)xwaand
(author)
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Regland, Björn,1947Gothenburg University,Göteborgs universitet,Institutionen för klinisk neurovetenskap,Institute of Clinical Neurosciences(Swepub:gu)xregbj
(author)
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Olofsson, H
(author)
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Hesse, CamillaGothenburg University,Göteborgs universitet,Institutionen för klinisk neurovetenskap,Institute of Clinical Neurosciences(Swepub:gu)xhesca
(author)
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Davidsson, Pia,1962Gothenburg University,Göteborgs universitet,Institutionen för klinisk neurovetenskap, Sektionen för laborativ neurovetenskap,Institute of Clinical Neurosciences, Section of Experimental Neuroscience(Swepub:gu)xdavpi
(author)
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Minthon, LennartLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups(Swepub:lu)psyk-lmi
(author)
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Jansson, Ann,1950Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin, Avdelningen för klinisk kemi/transfusionsmedicin,Institute of Laboratory Medicine, Dept of Clinical Chemistry/Transfusion Medicine(Swepub:gu)xjaann
(author)
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Palmqvist, Lars,1965Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin, Avdelningen för klinisk kemi/transfusionsmedicin,Institute of Laboratory Medicine, Dept of Clinical Chemistry/Transfusion Medicine(Swepub:gu)xpalla
(author)
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Rymo, Lars,1940Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin, Avdelningen för klinisk kemi/transfusionsmedicin,Institute of Laboratory Medicine, Dept of Clinical Chemistry/Transfusion Medicine(Swepub:gu)xrymla
(author)
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Göteborgs universitetInstitutionen för klinisk neurovetenskap, Sektionen för laborativ neurovetenskap
(creator_code:org_t)
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In:Journal of neural transmission (Vienna, Austria : 1996): Springer Science and Business Media LLC107:8-9, s. 1065-790300-95641435-1463
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Blennow, Kaj, 19 ...
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Ricksten, Anne, ...
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Prince, J A
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Brookes, A J
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Emahazion, T
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Wasslavik, Carin ...
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Bogdanovic, N
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Andreasen, Niels
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Båtsman, S
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Marcusson, Jan, ...
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Nägga, Katarina
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Wallin, Anders, ...
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Regland, Björn, ...
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Olofsson, H
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Hesse, Camilla
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Davidsson, Pia, ...
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Minthon, Lennart
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Jansson, Ann, 19 ...
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Palmqvist, Lars, ...
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Rymo, Lars, 1940
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Neurology
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University of Gothenburg
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Karolinska Institutet
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Lund University
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Linköping University