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Histamine Promotes ...
Histamine Promotes the Development of Monocyte-Derived Dendritic Cells and Reduces Tumor Growth by Targeting the Myeloid NADPH Oxidase
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- Martner, Anna, 1979 (författare)
- Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center
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- Grauers Wiktorin, Hanna, 1990 (författare)
- Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center
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- Lenox, Brianna (författare)
- Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center
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- Sander, Frida Ewald (författare)
- Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center
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- Aydin, Ebru (författare)
- Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center
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- Aurelius, Johan, 1980 (författare)
- Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center
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- Bergh Thorén, Fredrik, 1976 (författare)
- Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center
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- Ståhlberg, Anders, 1975 (författare)
- Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center
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- Hermodsson, Svante, 1934 (författare)
- Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center
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- Hellstrand, Kristoffer, 1956 (författare)
- Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center
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(creator_code:org_t)
- 2015-05-15
- 2015
- Engelska.
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Ingår i: Journal of Immunology. - : The American Association of Immunologists. - 0022-1767 .- 1550-6606. ; 194:10, s. 5014-5021
- Relaterad länk:
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https://www.jimmunol...
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https://gup.ub.gu.se...
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https://doi.org/10.4...
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Abstract
Ämnesord
Stäng
- The efficiency of immune-mediated clearance of cancer cells is hampered by immunosuppressive mediators in the malignant microenvironment, including NADPH oxidase-derived reactive oxygen species. We aimed at defining the effects of histamine, an inhibitor of the myeloid NADPH oxidase/NOX2, on the development of Ag-presenting dendritic cells (DCs) from myeloid precursors and the impact of these mechanisms for tumor growth. Histamine was found to promote the maturation of human DCs from monocytes by increasing the expression of HLA-DR and costimulatory molecules, which resulted in improved induction of Th cells with Th0 polarity. Experiments using wild-type and NOX2-deficient myelomonoblastic cells showed that histamine facilitated myeloid cell maturation only in cells capable of generating reactive oxygen species. Treatment of mice with histamine reduced the growth of murine EL-4 lymphomas in parallel with an increment of tumor-infiltrating DCs in NOX2-sufficient mice but not in NOX2-deficient (gp91(phox-/-)) mice. We propose that strategies to target the myeloid NADPH oxidase may facilitate the development of endogenous DCs in cancer.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Nyckelord
- REACTIVE OXYGEN METABOLITES
- ANTIGEN-PRESENTING CELLS
- CYTOKINE
- PRODUCTION
- LEUKEMIA
- CANCER
- DYSFUNCTION
- EXPRESSION
- RESPONSES
- ENCEPHALOMYELITIS
- DIFFERENTIATION
- Immunology
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- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Martner, Anna, 1 ...
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Grauers Wiktorin ...
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Lenox, Brianna
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Sander, Frida Ew ...
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Aydin, Ebru
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Aurelius, Johan, ...
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visa fler...
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Bergh Thorén, Fr ...
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Ståhlberg, Ander ...
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Hermodsson, Svan ...
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Hellstrand, Kris ...
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- MEDICIN OCH HÄLSOVETENSKAP
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Journal of Immun ...
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Göteborgs universitet