SwePub
Sök i LIBRIS databas

  Extended search

(LAR1:gu) pers:(Blennow Kaj 1958) pers:(Johnson S. C.)
 

Search: (LAR1:gu) pers:(Blennow Kaj 1958) pers:(Johnson S. C.) > (2015) > Insulin Resistance ...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist
  • Starks, E. J. (author)

Insulin Resistance is Associated with Higher Cerebrospinal Fluid Tau Levels in Asymptomatic APOE epsilon 4 Carriers

  • Article/chapterEnglish2015

Publisher, publication year, extent ...

  • IOS Press,2015

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/219066
  • https://gup.ub.gu.se/publication/219066URI
  • https://doi.org/10.3233/jad-150072DOI

Supplementary language notes

  • Language:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Background: Insulin resistance (IR) is linked with the occurrence of pathological features observed in Alzheimer's disease (AD), including neurofibrillary tangles and amyloid plaques. However, the extent to which IR is associated with AD pathology in the cognitively asymptomatic stages of preclinical AD remains unclear. Objective: To determine the extent to which IR is linked with amyloid and tau pathology in late-middle-age. Method: Cerebrospinal fluid (CSF) samples collected from 113 participants enrolled in the Wisconsin Registry for Alzheimer's Prevention study (mean age = 60.6 years), were assayed for AD-related markers of interest: A beta(42), P-Tau(181), and T-Tau. IR was determined using the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR). Linear regression was used to test the effect of IR, and APOE epsilon 4, on tau and amyloid pathology. We hypothesized that greater IR would be associated with higher CSF P-Tau181 and T-Tau, and lower CSF A beta 42. Results: No significant main effects of HOMA-IR on P-Tau181, T-Tau, or A beta 42 were observed; however, significant interactions were observed between HOMA-IR and APOE epsilon 4 on CSF markers related to tau. Among APOE epsilon 4 carriers, higher HOMA-IR was associated with higher P-Tau181 and T-Tau. Among APOE epsilon 4 non-carriers, HOMA-IR was negatively associated with P-Tau181 and T-Tau. We found no effects of IR on A beta 42 levels in CSF. Conclusion: IR among asymptomatic APOE epsilon 4 carriers was associated with higher P-Tau(181) and T-Tau in late-middle age. The results suggest that IR may contribute to tau-related neurodegeneration in preclinical AD. The findings may have implications for developing prevention strategies aimed at modifying IR in mid-life.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • O'Grady, J. P. (author)
  • Hoscheidt, S. M. (author)
  • Racine, A. M. (author)
  • Carlsson, C. M. (author)
  • Zetterberg, Henrik,1973Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xzethe (author)
  • Blennow, Kaj,1958Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xbleka (author)
  • Okonkwo, O. C. (author)
  • Puglielli, L. (author)
  • Asthana, S. (author)
  • Dowling, N. M. (author)
  • Gleason, C. E. (author)
  • Anderson, R. M. (author)
  • Davenport-Sis, N. J. (author)
  • DeRungs, L. M. (author)
  • Sager, M. A. (author)
  • Johnson, S. C. (author)
  • Bendlin, B. B. (author)
  • Göteborgs universitetInstitutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi (creator_code:org_t)

Related titles

  • In:Journal of Alzheimers Disease: IOS Press46:2, s. 525-5331387-28771875-8908

Internet link

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view