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Roles of miRNAs in ...
Roles of miRNAs in microcystin-LR-induced Sertoli cell toxicity
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- Zhou, Y. (author)
- Nanjing University, Peoples R China; Nanjing University, Peoples R China; Nanjing University, Peoples R China
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- Wang, Hui (author)
- Linköpings universitet,Avdelningen för kliniska vetenskaper,Medicinska fakulteten
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- Wang, C. (author)
- Nanjing University, Peoples R China; Nanjing University, Peoples R China; Nanjing University, Peoples R China
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- Qiu, X. F. (author)
- Nanjing University, Peoples R China
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- Benson, Mikael (author)
- Linköpings universitet,Avdelningen för kliniska vetenskaper,Medicinska fakulteten,Region Östergötland, Allergicentrum US
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- Yin, X. Q. (author)
- Nanjing University, Peoples R China; Nanjing University, Peoples R China; Nanjing University, Peoples R China
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- Xiang, Zou (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology,University of Gothenburg, Sweden
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- Li, D. M. (author)
- Nanjing University, Peoples R China; Nanjing University, Peoples R China; Nanjing University, Peoples R China
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- Han, X. D. (author)
- Nanjing University, Peoples R China; Nanjing University, Peoples R China; Nanjing University, Peoples R China
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(creator_code:org_t)
- Elsevier BV, 2015
- 2015
- English.
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In: Toxicology and Applied Pharmacology. - : Elsevier BV. - 0041-008X .- 1096-0333. ; 287:1, s. 1-8
- Related links:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Subject headings
Close
- Microcystin (MC)-LR, a cyclic heptapeptide, is a potent reproductive system toxin. To understand the molecular mechanisms of MC-induced reproductive system cytotoxicity, we evaluated global changes of miRNA and mRNA expression in mouse Sertoli cells following MC-LR treatment. Our results revealed that the exposure to MC-LR resulted in an altered miRNA expression profile that might be responsible for the modulation of mRNA expression. Bio-functional analysis indicated that the altered genes were involved in specific cellular processes, including cell death and proliferation. Target gene analysis suggested that junction injury in Sertoli cells exposed to MC-LR might be mediated by miRNAs through the regulation of the Sertoli cell-Sertoli cell pathway. Collectively, these findings may enhance our understanding on the modes of action of MC-LR on mouse Sertoli cells as well as the molecular mechanisms underlying the toxicity of MC-LR on the male reproductive system. (C) 2015 Elsevier Inc. All rights reserved.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- Microcystin-LR
- microRNA
- mRNA
- Sertoli cell
- Bioinformatics
- Toxicity
- PROTEIN ZO-1 ESTABLISHES
- MICRORNA EXPRESSION
- ACTIN CYTOSKELETON
- RAT
- HEPATOCYTES
- IN-VITRO
- OCCLUDIN
- MICE
- CYANOBACTERIA
- NONYLPHENOL
- APOPTOSIS
- Pharmacology & Pharmacy
- Toxicology
- Microcystin-LR; microRNA; mRNA; Sertoli cell; Bioinformatics; Toxicity
Publication and Content Type
- ref (subject category)
- art (subject category)
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