Search: id:"swepub:oai:gup.ub.gu.se/220196" >
Characterising temp...
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Morris, U.Karolinska Institutet
(author)
Characterising temporal trends in asymptomatic Plasmodium infections and transporter polymorphisms during transition from high to low transmission in Zanzibar, 2005-2013
- Article/chapterEnglish2015
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LIBRIS-ID:oai:gup.ub.gu.se/220196
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https://gup.ub.gu.se/publication/220196URI
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https://doi.org/10.1016/j.meegid.2015.04.018DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:131588443URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-252880URI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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Swedish Civil Contingencies Agency (MSB) and Goljes Foundation
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Background: Improved understanding of the asymptomatic malaria parasite reservoir is a prerequisite to pursue malaria elimination efforts. We therefore characterised temporal trends and transporter polymorphisms in asymptomatic Plasmodium infections during the transition from high to low transmission in Zanzibar. Methods: Healthy individuals participating in cross-sectional surveys conducted 2005-2013 were screened for asymptomatic malaria by PCR. Complexity/diversity of infection and transporter polymorphisms were assessed in Plasmodium falciparum positive samples. Symptomatic samples were included for comparison of polymorphisms in 2013. Results: PCR-determined parasite prevalence declined from 21.1% (CI95% 17.4-24.9) to 2.3% (CI95% 1.7-2.9) from 2005 to 2013. P. falciparum remained the predominant species; prevalence was highest in children and young adults aged 5-25 years. Parasite densities and complexity of infection, but not population genetic diversity of P. falciparum, decreased from 2005-2009. pfcrt 761 (99.2-64.7%, p < 0.001) and pfmdr1 86Y frequencies (89.4-66.7%, p = 0.03) decreased over time. Pfmdr1 (a.a.86,184,1246) YYY and YYD haplotypes were more frequent in asymptomatic than symptomatic infections in 2013 (p < 0.001). Conclusions: There is a declining, albeit persistent, reservoir of parasites present at low-densities in asymptomatic individuals in Zanzibar. This study revealed important characteristics of the remaining parasite population, including intriguing temporal trends in molecular markers associated with antimalarial resistance, which need to be further investigated. (C) 2015 Elsevier B.V. All rights reserved.
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Xu, W. P.
(author)
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Msellem, M. I.
(author)
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Schwartz, A.
(author)
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Abass, A.Karolinska Institutet
(author)
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Shakely, D.
(author)
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Cook, J.
(author)
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Bhattarai, A.
(author)
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Petzold, Max,1973Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine(Swepub:gu)xpemax
(author)
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Greenhouse, B.
(author)
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Ali, A. S.
(author)
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Bjorkman, A.
(author)
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Froberg, G.Karolinska Institutet
(author)
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Mårtensson, AndreasUppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD)(Swepub:uu)andma331
(author)
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Karolinska InstitutetInstitutionen för medicin
(creator_code:org_t)
Related titles
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In:Infection Genetics and Evolution: Elsevier BV33, s. 110-1171567-13481567-7257
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In:Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases: Elsevier BV33, s. 110-1171567-7257
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Morris, U.
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Xu, W. P.
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Msellem, M. I.
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Schwartz, A.
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Abass, A.
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Shakely, D.
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Cook, J.
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Bhattarai, A.
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Petzold, Max, 19 ...
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Greenhouse, B.
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Ali, A. S.
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Bjorkman, A.
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Froberg, G.
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Mårtensson, Andr ...
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University of Gothenburg
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Karolinska Institutet
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