Characterising temporal trends in asymptomatic Plasmodium infections and transporter polymorphisms during transition from high to low transmission in Zanzibar, 2005-2013

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: id:"swepub:oai:gup.ub.gu.se/220196" > Characterising temp...

1 of 1
Previous record
Next record
To hitlist

Details
MARC

Morris, U.Karolinska Institutet (author)

Characterising temporal trends in asymptomatic Plasmodium infections and transporter polymorphisms during transition from high to low transmission in Zanzibar, 2005-2013

Article/chapterEnglish2015

Publisher, publication year, extent ...

Elsevier BV,2015

Numbers

LIBRIS-ID:oai:gup.ub.gu.se/220196
https://gup.ub.gu.se/publication/220196URI
https://doi.org/10.1016/j.meegid.2015.04.018DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:131588443URI
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-252880URI

Supplementary language notes

Language:English

Part of subdatabase

SwePubSwePub

Classification

Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Swedish Civil Contingencies Agency (MSB) and Goljes Foundation
Background: Improved understanding of the asymptomatic malaria parasite reservoir is a prerequisite to pursue malaria elimination efforts. We therefore characterised temporal trends and transporter polymorphisms in asymptomatic Plasmodium infections during the transition from high to low transmission in Zanzibar. Methods: Healthy individuals participating in cross-sectional surveys conducted 2005-2013 were screened for asymptomatic malaria by PCR. Complexity/diversity of infection and transporter polymorphisms were assessed in Plasmodium falciparum positive samples. Symptomatic samples were included for comparison of polymorphisms in 2013. Results: PCR-determined parasite prevalence declined from 21.1% (CI95% 17.4-24.9) to 2.3% (CI95% 1.7-2.9) from 2005 to 2013. P. falciparum remained the predominant species; prevalence was highest in children and young adults aged 5-25 years. Parasite densities and complexity of infection, but not population genetic diversity of P. falciparum, decreased from 2005-2009. pfcrt 761 (99.2-64.7%, p < 0.001) and pfmdr1 86Y frequencies (89.4-66.7%, p = 0.03) decreased over time. Pfmdr1 (a.a.86,184,1246) YYY and YYD haplotypes were more frequent in asymptomatic than symptomatic infections in 2013 (p < 0.001). Conclusions: There is a declining, albeit persistent, reservoir of parasites present at low-densities in asymptomatic individuals in Zanzibar. This study revealed important characteristics of the remaining parasite population, including intriguing temporal trends in molecular markers associated with antimalarial resistance, which need to be further investigated. (C) 2015 Elsevier B.V. All rights reserved.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Infektionsmedicin hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Infectious Medicine hsv//eng
Asymptomatic
Plasmodium
Low transmission
Molecular surveillance
Antimalarial drug resistance
POLYMERASE-CHAIN-REACTION
FALCIPARUM DRUG-RESISTANCE
MALARIA PARASITE
CARRIAGE
RAPID DIAGNOSTIC-TESTS
MOLECULAR SURVEILLANCE
IN-VITRO
ARTEMETHER-LUMEFANTRINE
ARTESUNATE-AMODIAQUINE
COMBINATION THERAPY
PFMDR1 GENES
Infectious Diseases

Added entries (persons, corporate bodies, meetings, titles ...)

Xu, W. P. (author)
Msellem, M. I. (author)
Schwartz, A. (author)
Abass, A.Karolinska Institutet (author)
Shakely, D. (author)
Cook, J. (author)
Bhattarai, A. (author)
Petzold, Max,1973Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine(Swepub:gu)xpemax (author)
Greenhouse, B. (author)
Ali, A. S. (author)
Bjorkman, A. (author)
Froberg, G.Karolinska Institutet (author)
Mårtensson, AndreasUppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD)(Swepub:uu)andma331 (author)
Karolinska InstitutetInstitutionen för medicin (creator_code:org_t)

Related titles

In:Infection Genetics and Evolution: Elsevier BV33, s. 110-1171567-13481567-7257
In:Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases: Elsevier BV33, s. 110-1171567-7257

Internet link

Find in a library

Infection Genetics and Evolution (Search for host publication in LIBRIS)

To the university's database

1 of 1
Previous record
Next record
To hitlist

Find more in SwePub

By the author/editor: Morris, U.; Xu, W. P.; Msellem, M. I.; Schwartz, A.; Abass, A.; Shakely, D.; show more...; Cook, J.; Bhattarai, A.; Petzold, Max, 19 ...; Greenhouse, B.; Ali, A. S.; Bjorkman, A.; Froberg, G.; Mårtensson, Andr ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Infectious Medic ...

Articles in the publication: Infection Geneti ...; Infection, genet ...

By the university: University of Gothenburg; Karolinska Institutet; Uppsala University

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se