Search: (WFRF:(Andrén Per E.)) pers:(Welinder Charlotte)
> (2015) >
Association of chro...
Association of chromosome 19 to lung cancer genotypes and phenotypes
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Wang, X. D. (author)
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Zhang, Y. (author)
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- Nilsson, Carol (author)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Department of Clinical Sciences, Lund,Faculty of Medicine,University of Texas
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Berven, F. S. (author)
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- Andrén, Per E. (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap
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- Carlsohn, Elisabet (author)
- Gothenburg University,Göteborgs universitet,Core Facilities, Proteomics,Core Facilities, Proteomics
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Horvatovich, P. (author)
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- Malm, Johan (author)
- Lund University,Lunds universitet,Klinisk kemi, Malmö,Forskargrupper vid Lunds universitet,Clinical Chemistry, Malmö,Lund University Research Groups
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Fuentes, M. (author)
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- Végvári, Ákos (author)
- Lund University,Lunds universitet,Avdelningen för Biomedicinsk teknik,Institutionen för biomedicinsk teknik,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Biomedical Engineering,Departments at LTH,Faculty of Engineering, LTH
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- Welinder, Charlotte (author)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Fehniger, Thomas (author)
- Lund University,Lunds universitet,Avdelningen för Biomedicinsk teknik,Institutionen för biomedicinsk teknik,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Biomedical Engineering,Departments at LTH,Faculty of Engineering, LTH
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- Rezeli, Melinda (author)
- Lund University,Lunds universitet,Avdelningen för Biomedicinsk teknik,Institutionen för biomedicinsk teknik,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Biomedical Engineering,Departments at LTH,Faculty of Engineering, LTH
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Edula, G. (author)
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- Hober, Sophia (author)
- KTH,Proteinteknologi
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Nishimura, T. (author)
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- Marko-Varga, György (author)
- Lund University,Lunds universitet,Clinical Protein Science and Imaging,Forskargrupper vid Lunds universitet,Lund University Research Groups,Tokyo Medical University
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(creator_code:org_t)
- 2015-05-16
- 2015
- English.
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In: Cancer and Metastasis Reviews. - : Springer Science and Business Media LLC. - 0167-7659 .- 1573-7233. ; 34:2, s. 217-226
- Related links:
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http://dx.doi.org/10...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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Abstract
Subject headings
Close
- The Chromosome 19 Consortium, a part of the Chromosome-Centric Human Proteome Project (C-HPP, ), is tasked with the understanding chromosome 19 functions at the gene and protein levels, as well as their roles in lung oncogenesis. Comparative genomic hybridization (CGH) studies revealed chromosome aberration in lung cancer subtypes, including ADC, SCC, LCC, and SCLC. The most common abnormality is 19p loss and 19q gain. Sixty-four aberrant genes identified in previous genomic studies and their encoded protein functions were further validated in the neXtProt database (). Among those, the loss of tumor suppressor genes STK11, MUM1, KISS1R (19p13.3), and BRG1 (19p13.13) is associated with lung oncogenesis or remote metastasis. Gene aberrations include translocation t(15, 19) (q13, p13.1) fusion oncogene BRD4-NUT, DNA repair genes (ERCC1, ERCC2, XRCC1), TGF beta 1 pathway activation genes (TGFB1, LTBP4), Dyrk1B, and potential oncogenesis protector genes such as NFkB pathway inhibition genes (NFKBIB, PPP1R13L) and EGLN2. In conclusion, neXtProt is an effective resource for the validation of gene aberrations identified in genomic studies. It promises to enhance our understanding of lung cancer oncogenesis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Proteins
- Genes
- Antibodies
- mRNA
- Mass spectrometry
- Bioinformatics
- Protein microarray
- Human
- COMPARATIVE GENOMIC HYBRIDIZATION
- NF-KAPPA-B
- CHINESE POPULATION
- ALLELIC IMBALANCE
- ARRAY ANALYSIS
- IN-VITRO
- CARCINOMA
- CELLS
- GENE
- RISK
- Oncology
- Proteins
Publication and Content Type
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To the university's database
- By the author/editor
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Wang, X. D.
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Zhang, Y.
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Nilsson, Carol
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Berven, F. S.
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Andrén, Per E.
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Carlsohn, Elisab ...
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show more...
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Horvatovich, P.
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Malm, Johan
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Fuentes, M.
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Végvári, Ákos
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Welinder, Charlo ...
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Fehniger, Thomas
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Rezeli, Melinda
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Edula, G.
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Hober, Sophia
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Nishimura, T.
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Marko-Varga, Gyö ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Cancer and Metas ...
- By the university
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University of Gothenburg
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Lund University
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Royal Institute of Technology
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Uppsala University