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Prevalence Estimate...
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Jansen, Willemijn JAlzheimer Centre Limburg, Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, the Netherlands; Banner Alzheimer's Institute, Phoenix, Arizona, USA
(author)
Prevalence Estimates of Amyloid Abnormality Across the Alzheimer Disease Clinical Spectrum.
- Article/chapterEnglish2022
Publisher, publication year, extent ...
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American Medical Association (AMA),2022
Numbers
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LIBRIS-ID:oai:gup.ub.gu.se/321350
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https://gup.ub.gu.se/publication/321350URI
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https://doi.org/10.1001/jamaneurol.2021.5216DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-97171URI
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https://lup.lub.lu.se/record/bcd4db38-4bed-4703-bdc8-c37368962136URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:148745137URI
Supplementary language notes
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Funding Agency:Biogen
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One characteristic histopathological event in Alzheimer disease (AD) is cerebral amyloid aggregation, which can be detected by biomarkers in cerebrospinal fluid (CSF) and on positron emission tomography (PET) scans. Prevalence estimates of amyloid pathology are important for health care planning and clinical trial design.To estimate the prevalence of amyloid abnormality in persons with normal cognition, subjective cognitive decline, mild cognitive impairment, or clinical AD dementia and to examine the potential implications of cutoff methods, biomarker modality (CSF or PET), age, sex, APOE genotype, educational level, geographical region, and dementia severity for these estimates.This cross-sectional, individual-participant pooled study included participants from 85 Amyloid Biomarker Study cohorts. Data collection was performed from January 1, 2013, to December 31, 2020. Participants had normal cognition, subjective cognitive decline, mild cognitive impairment, or clinical AD dementia. Normal cognition and subjective cognitive decline were defined by normal scores on cognitive tests, with the presence of cognitive complaints defining subjective cognitive decline. Mild cognitive impairment and clinical AD dementia were diagnosed according to published criteria.Alzheimer disease biomarkers detected on PET or in CSF.Amyloid measurements were dichotomized as normal or abnormal using cohort-provided cutoffs for CSF or PET or by visual reading for PET. Adjusted data-driven cutoffs for abnormal amyloid were calculated using gaussian mixture modeling. Prevalence of amyloid abnormality was estimated according to age, sex, cognitive status, biomarker modality, APOE carrier status, educational level, geographical location, and dementia severity using generalized estimating equations.Among the 19097 participants (mean [SD] age, 69.1 [9.8] years; 10148 women [53.1%]) included, 10139 (53.1%) underwent an amyloid PET scan and 8958 (46.9%) had an amyloid CSF measurement. Using cohort-provided cutoffs, amyloid abnormality prevalences were similar to 2015 estimates for individuals without dementia and were similar across PET- and CSF-based estimates (24%; 95% CI, 21%-28%) in participants with normal cognition, 27% (95% CI, 21%-33%) in participants with subjective cognitive decline, and 51% (95% CI, 46%-56%) in participants with mild cognitive impairment, whereas for clinical AD dementia the estimates were higher for PET than CSF (87% vs 79%; mean difference, 8%; 95% CI, 0%-16%; P=.04). Gaussian mixture modeling-based cutoffs for amyloid measures on PET scans were similar to cohort-provided cutoffs and were not adjusted. Adjusted CSF cutoffs resulted in a 10% higher amyloid abnormality prevalence than PET-based estimates in persons with normal cognition (mean difference, 9%; 95% CI, 3%-15%; P=.004), subjective cognitive decline (9%; 95% CI, 3%-15%; P=.005), and mild cognitive impairment (10%; 95% CI, 3%-17%; P=.004), whereas the estimates were comparable in persons with clinical AD dementia (mean difference, 4%; 95% CI, -2% to 9%; P=.18).This study found that CSF-based estimates using adjusted data-driven cutoffs were up to 10% higher than PET-based estimates in people without dementia, whereas the results were similar among people with dementia. This finding suggests that preclinical and prodromal AD may be more prevalent than previously estimated, which has important implications for clinical trial recruitment strategies and health care planning policies.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Janssen, OlinAlzheimer Centre Limburg, Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, the Netherlands
(author)
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Tijms, Betty MAlzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam University Medical Center (UMC), Amsterdam, the Netherlands
(author)
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Vos, Stephanie J BAlzheimer Centre Limburg, Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, the Netherlands
(author)
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Ossenkoppele, RikKarolinska Institutet,Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups(Swepub:lu)ri1513os
(author)
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Visser, Pieter JelleKarolinska Institutet,Vrije Universiteit Amsterdam,Maastricht University
(author)
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Aarsland, Dag
(author)
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Alcolea, Daniel
(author)
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Altomare, Daniele
(author)
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von Arnim, Christine
(author)
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Baiardi, Simone
(author)
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Baldeiras, Ines
(author)
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Barthel, Henryk
(author)
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Bateman, Randall J
(author)
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Van Berckel, Bart
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Binette, Alexa Pichet
(author)
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Blennow, Kaj,1958Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xbleka
(author)
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Boada, Merce
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Boecker, Henning
(author)
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Bottlaender, Michel
(author)
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den Braber, Anouk
(author)
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Brooks, David J
(author)
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Van Buchem, Mark A
(author)
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Camus, Vincent
(author)
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Carill, Jose Manuel
(author)
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Cerman, Jiri
(author)
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Chen, Kewei
(author)
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Chételat, Gaël
(author)
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Chipi, Elena
(author)
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Cohen, Ann D
(author)
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Daniels, Alisha
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Delarue, Marion
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Didic, Mira
(author)
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Drzezga, Alexander
(author)
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Dubois, Bruno
(author)
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Eckerström, MarieGothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
(author)
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Ekblad, Laura L
(author)
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Engelborghs, Sebastiaan
(author)
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Epelbaum, Stéphane
(author)
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Fagan, Anne M
(author)
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Fan, Yong
(author)
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Fladby, Tormod
(author)
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Fleisher, Adam S
(author)
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Van der Flier, Wiesje M
(author)
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Förster, Stefan
(author)
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Fortea, Juan
(author)
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Frederiksen, Kristian Steen
(author)
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Freund-Levi, Yvonne,1956-Örebro universitet,Institutionen för medicinska vetenskaper,Department of Neurobiology, Care Sciences and Society, Division of Clinical Geriatrics, Karolinska Institutet Center for Alzheimer Research, Stockholm, Sweden; Department of Old Age Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom,Amyloid Biomarker Study Group(Swepub:oru)yfi
(author)
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Frings, Lars
(author)
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Frisoni, Giovanni B
(author)
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Fröhlich, Lutz
(author)
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Gabryelewicz, Tomasz
(author)
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Gertz, Hermann-Josef
(author)
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Gill, Kiran Dip
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Gkatzima, Olymbia
(author)
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Gómez-Tortosa, Estrella
(author)
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Grimmer, Timo
(author)
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Guedj, Eric
(author)
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Habeck, Christian G
(author)
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Hampel, Harald
(author)
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Handels, Ron
(author)
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Hansson, Oskar
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Hausner, Lucrezia
(author)
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Hellwig, Sabine
(author)
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Heneka, Michael T
(author)
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Herukka, Sanna-Kaisa
(author)
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Hildebrandt, Helmut
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Hodges, John
(author)
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Hort, Jakub
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Huang, Chin-Chang
(author)
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Iriondo, Ane Juaristi
(author)
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Itoh, Yoshiaki
(author)
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Ivanoiu, Adrian
(author)
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Jagust, William J
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Jessen, Frank
(author)
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Johannsen, Peter
(author)
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Johnson, Keith A
(author)
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Kandimalla, Ramesh
(author)
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Kapaki, Elisabeth N
(author)
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Kern, SilkeGothenburg University,Göteborgs universitet,Centrum för åldrande och hälsa (AgeCap),Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Centre for Ageing and Health (Agecap),Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xkersi
(author)
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Kilander, Lena
(author)
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Klimkowicz-Mrowiec, Aleksandra
(author)
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Klunk, William E
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Koglin, Norman
(author)
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Kornhuber, Johannes
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Kramberger, Milica G
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Kuo, Hung-Chou
(author)
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Van Laere, Koen
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Landau, Susan M
(author)
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Landeau, Brigitte
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Lee, Dong Young
(author)
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de Leon, Mony
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Leyton, Cristian E
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Lin, Kun-Ju
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Lleó, Alberto
(author)
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Löwenmark, Malin
(author)
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Madsen, Karine
(author)
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Maier, Wolfgang
(author)
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Marcusson, Jan
(author)
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Marquié, Marta
(author)
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Martinez-Lage, Pablo
(author)
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Maserejian, Nancy
(author)
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Mattsson, Niklas
(author)
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de Mendonça, Alexandre
(author)
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Meyer, Philipp T
(author)
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Miller, Bruce L
(author)
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Minatani, Shinobu
(author)
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Mintun, Mark A
(author)
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Mok, Vincent C T
(author)
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Molinuevo, Jose Luis
(author)
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Morbelli, Silvia Daniela
(author)
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Morris, John C
(author)
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Mroczko, Barbara
(author)
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Na, Duk L
(author)
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Newberg, Andrew
(author)
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Nobili, Flavio
(author)
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Nordberg, Agneta
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Olde Rikkert, Marcel G M
(author)
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de Oliveira, Catarina Resende
(author)
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Olivieri, Pauline
(author)
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Orellana, Adela
(author)
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Paraskevas, George
(author)
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Parchi, Piero
(author)
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Pardini, Matteo
(author)
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Parnetti, Lucilla
(author)
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Peters, Oliver
(author)
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Poirier, Judes
(author)
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Popp, Julius
(author)
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Prabhakar, Sudesh
(author)
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Rabinovici, Gil D
(author)
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Ramakers, Inez H
(author)
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Rami, Lorena
(author)
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Reiman, Eric M
(author)
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Rinne, Juha O
(author)
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Rodrigue, Karen M
(author)
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Rodríguez-Rodriguez, Eloy
(author)
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Roe, Catherine M
(author)
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Rosa-Neto, Pedro
(author)
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Rosen, Howard J
(author)
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Rot, Uros
(author)
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Rowe, Christopher C
(author)
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Rüther, Eckart
(author)
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Ruiz, Agustín
(author)
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Sabri, Osama
(author)
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Sakhardande, Jayant
(author)
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Sánchez-Juan, Pascual
(author)
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Sando, Sigrid Botne
(author)
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Santana, Isabel
(author)
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Sarazin, Marie
(author)
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Scheltens, Philip
(author)
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Schröder, Johannes
(author)
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Selnes, Per
(author)
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Seo, Sang Won
(author)
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Silva, Dina
(author)
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Skoog, Ingmar,1954Gothenburg University,Göteborgs universitet,Centrum för åldrande och hälsa (AgeCap),Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Centre for Ageing and Health (Agecap),Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xskooi
(author)
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Snyder, Peter J
(author)
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Soininen, Hilkka
(author)
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Sollberger, Marc
(author)
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Sperling, Reisa A
(author)
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Spiru, Luisa
(author)
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Stern, Yaakov
(author)
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Stomrud, Erik
(author)
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Takeda, Akitoshi
(author)
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Teichmann, Marc
(author)
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Teunissen, Charlotte E
(author)
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Thompson, Louisa I
(author)
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Tomassen, Jori
(author)
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Tsolaki, Magda
(author)
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Vandenberghe, Rik
(author)
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Verbeek, Marcel M
(author)
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Verhey, Frans R J
(author)
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Villemagne, Victor
(author)
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Villeneuve, Sylvia
(author)
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Vogelgsang, Jonathan
(author)
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Waldemar, Gunhild
(author)
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Wallin, ÅsaLund University,Lunds universitet,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Centrum för åldrande och hälsa (AgeCap),Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Centre for Ageing and Health (Agecap),Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups(Swepub:lu)med-was
(author)
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Wallin, Åsa K
(author)
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Wiltfang, Jens
(author)
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Wolk, David A
(author)
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Yen, Tzu-Chen
(author)
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Zboch, Marzena
(author)
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Zetterberg, Henrik,1973Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xzethe
(author)
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Alzheimer Centre Limburg, Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, the Netherlands; Banner Alzheimer's Institute, Phoenix, Arizona, USAAlzheimer Centre Limburg, Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, the Netherlands
(creator_code:org_t)
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Amyloid Biomarker Study Group
Related titles
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In:JAMA neurology: American Medical Association (AMA)79:3, s. 228-2432168-61572168-6149
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Jansen, Willemij ...
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Janssen, Olin
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Vos, Stephanie J ...
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Visser, Pieter J ...
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den Braber, Anou ...
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Carill, Jose Man ...
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Chipi, Elena
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Engelborghs, Seb ...
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Fagan, Anne M
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Fan, Yong
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Fladby, Tormod
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Förster, Stefan
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Fortea, Juan
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Frederiksen, Kri ...
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Freund-Levi, Yvo ...
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Frisoni, Giovann ...
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Fröhlich, Lutz
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Gabryelewicz, To ...
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Gill, Kiran Dip
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Gkatzima, Olymbi ...
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Gómez-Tortosa, E ...
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Grimmer, Timo
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Guedj, Eric
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Habeck, Christia ...
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Hampel, Harald
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Handels, Ron
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Hansson, Oskar
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Hausner, Lucrezi ...
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Hellwig, Sabine
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Heneka, Michael ...
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Herukka, Sanna-K ...
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Hildebrandt, Hel ...
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Hodges, John
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Hort, Jakub
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Huang, Chin-Chan ...
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Iriondo, Ane Jua ...
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Itoh, Yoshiaki
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Ivanoiu, Adrian
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Jagust, William ...
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Jessen, Frank
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Johannsen, Peter
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Johnson, Keith A
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Kandimalla, Rame ...
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Kapaki, Elisabet ...
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Kern, Silke
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Kilander, Lena
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Klimkowicz-Mrowi ...
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Klunk, William E
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Koglin, Norman
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Kornhuber, Johan ...
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Kramberger, Mili ...
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Kuo, Hung-Chou
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Van Laere, Koen
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Landau, Susan M
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Landeau, Brigitt ...
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Lee, Dong Young
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de Leon, Mony
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Leyton, Cristian ...
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Lin, Kun-Ju
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Lleó, Alberto
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Löwenmark, Malin
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Madsen, Karine
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Maier, Wolfgang
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Marcusson, Jan
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Marquié, Marta
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Martinez-Lage, P ...
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Maserejian, Nanc ...
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Mattsson, Niklas
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de Mendonça, Ale ...
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Meyer, Philipp T
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Miller, Bruce L
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Minatani, Shinob ...
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Mintun, Mark A
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Mok, Vincent C T
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Molinuevo, Jose ...
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Morbelli, Silvia ...
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Morris, John C
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Mroczko, Barbara
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Na, Duk L
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Newberg, Andrew
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Nobili, Flavio
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Nordberg, Agneta
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Olde Rikkert, Ma ...
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de Oliveira, Cat ...
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Olivieri, Paulin ...
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Orellana, Adela
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Paraskevas, Geor ...
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Parchi, Piero
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Pardini, Matteo
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Peters, Oliver
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Poirier, Judes
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Popp, Julius
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Prabhakar, Sudes ...
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Rabinovici, Gil ...
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Ramakers, Inez H
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Rami, Lorena
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Reiman, Eric M
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Snyder, Peter J
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- MEDICAL AND HEALTH SCIENCES
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and Neurology
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JAMA neurology
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University of Gothenburg
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Örebro University
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Lund University
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Karolinska Institutet