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Increased Eotaxin a...
Increased Eotaxin and MCP-1 Levels in Serum from Individuals with Periodontitis and in Human Gingival Fibroblasts Exposed to Pro-Inflammatory Cytokines
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- Bostrom, E. A. (författare)
- Karolinska Institutet
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- Kindstedt, Elin (författare)
- Umeå universitet,Institutionen för odontologi
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- Sulniute, Rima (författare)
- Umeå universitet,Institutionen för odontologi
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- Palmqvist, Py (författare)
- Umeå universitet,Institutionen för odontologi
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- Majster, M. (författare)
- Karolinska Institutet
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- Holm, Cecilia Koskinen (författare)
- Umeå universitet,Institutionen för odontologi
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- Zwicker, S. (författare)
- Karolinska Institutet
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- Clark, R. (författare)
- Karolinska Institutet
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Onell, S. (författare)
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- Johansson, Ingegerd (författare)
- Umeå universitet,Institutionen för odontologi
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- Lerner, Ulf H (författare)
- Umeå universitet,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Institutionen för odontologi,Univ Gothenburg, Sahlgrenska Acad, Ctr Bone & Arthrit Res, Gothenburg, Sweden
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- Lundberg, Pernilla (författare)
- Umeå universitet,Institutionen för odontologi
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(creator_code:org_t)
- 2015-08-04
- 2015
- Engelska.
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Ingår i: Plos One. - : Public Library of Science (PLoS). - 1932-6203. ; 10:8
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https://doi.org/10.1...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Periodontitis is a chronic inflammatory disease of tooth supporting tissues resulting in periodontal tissue destruction, which may ultimately lead to tooth loss. The disease is characterized by continuous leukocyte infiltration, likely mediated by local chemokine production but the pathogenic mechanisms are not fully elucidated. There are no reliable serologic biomarkers for the diagnosis of periodontitis, which is today based solely on the degree of local tissue destruction, and there is no available biological treatment tool. Prompted by the increasing interest in periodontitis and systemic inflammatory mediators we mapped serum cytokine and chemokine levels from periodontitis subjects and healthy controls. We used multivariate partial least squares (PLS) modeling and identified monocyte chemoattractant protein-1 (MCP-1) and eotaxin as clearly associated with periodontitis along with C-reactive protein (CRP), years of smoking and age, whereas the number of remaining teeth was associated with being healthy. Moreover, body mass index correlated significantly with serum MCP-1 and CRP, but not with eotaxin. We detected higher MCP-1 protein levels in inflamed gingival connective tissue compared to healthy but the eotaxin levels were undetectable. Primary human gingival fibroblasts displayed strongly increased expression of MCP-1 and eotaxin mRNA and protein when challenged with tumor necrosis factor-alpha (TNF-alpha and interleukin-1 beta (IL-1 beta), key mediators of periodontal inflammation. We also demonstrated that the upregulated chemokine expression was dependent on the NF-kappa B pathway. In summary, we identify higher levels of CRP, eotaxin and MCP-1 in serum of periodontitis patients. This, together with our finding that both CRP and MCP-1 correlates with BMI points towards an increased systemic inflammatory load in patients with periodontitis and high BMI. Targeting eotaxin and MCP-1 in periodontitis may result in reduced leukocyte infiltration and inflammation in periodontitis and maybe prevent tooth loss.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Odontologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dentistry (hsv//eng)
Nyckelord
- MONOCYTE CHEMOATTRACTANT PROTEIN-1
- NECROSIS-FACTOR-ALPHA
- KAPPA-B
- KINASE
- RHEUMATOID-ARTHRITIS
- CREVICULAR FLUID
- HUMAN ATHEROSCLEROSIS
- CLINICAL-PARAMETERS
- SMOOTH-MUSCLE
- TNF-ALPHA
- BONE LOSS
- Multidisciplinary Sciences
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
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Plos One
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Till lärosätets databas
- Av författaren/redakt...
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Bostrom, E. A.
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Kindstedt, Elin
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Sulniute, Rima
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Palmqvist, Py
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Majster, M.
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Holm, Cecilia Ko ...
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visa fler...
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Zwicker, S.
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Clark, R.
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Onell, S.
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Johansson, Ingeg ...
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Lerner, Ulf H
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Lundberg, Pernil ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Endokrinologi oc ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Odontologi
- Artiklar i publikationen
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Plos One
- Av lärosätet
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Göteborgs universitet
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Umeå universitet
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Karolinska Institutet