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Stem cell-derived e...
Stem cell-derived exosomes: roles in stromal remodeling, tumor progression, and cancer immunotherapy
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- Fatima, Farah (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research
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- Nawaz, Muhammad (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research
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(creator_code:org_t)
- 2015-09-14
- 2015
- Engelska.
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Ingår i: Cancer Communications. - : Springer Science and Business Media LLC. - 2523-3548. ; 34:12, s. 541-53
- Relaterad länk:
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https://cancercommun...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Stem cells are known to maintain stemness at least in part through secreted factors that promote stem-like phenotypes in resident cells. Accumulating evidence has clarified that stem cells release nano-vesicles, known as exosomes, which may serve as mediators of cell-to-cell communication and may potentially transmit stem cell phenotypes to recipient cells, facilitating stem cell maintenance, differentiation, self-renewal, and repair. It has become apparent that stem cell-derived exosomes mediate interactions among stromal elements, promote genetic instability in recipient cells, and induce malignant transformation. This review will therefore discuss the potential of stem cell-derived exosomes in the context of stromal remodeling and their ability to generate cancer-initiating cells in a tumor niche by inducing morphologic and functional differentiation of fibroblasts into tumor-initiating fibroblasts. In addition, the immunosuppressive potential of stem cell-derived exosomes in cancer immunotherapy and their prospective applications in cell-free therapies in future translational medicine is discussed.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Nyckelord
- Stem cells
- Exosomes
- MicroRNAs
- Fibroblasts
- Stroma
- Tumor microenvironment
- Angiogenesis
- versus-host-disease
- acute lung injury
- extracellular vesicles
- breast-cancer
- in-vitro
- myocardial-infarction
- microvesicles protect
- emerging role
- cardiomyocyte apoptosis
- inflammatory diseases
- Oncology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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