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IgG1 anti-cell wall...
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Mattsby-Baltzer, Inger,1949Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
(författare)
IgG1 anti-cell wall and IgG2 anti-phosphopeptidomannan antibodies in the diagnosis of invasive candidiasis and heavy Candida colonization
- Artikel/kapitelEngelska2015
Förlag, utgivningsår, omfång ...
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2015-07-10
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Oxford University Press (OUP),2015
Nummerbeteckningar
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LIBRIS-ID:oai:gup.ub.gu.se/224034
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https://gup.ub.gu.se/publication/224034URI
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https://doi.org/10.1093/mmy/myv037DOI
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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We conducted a retrospective study to evaluate the usefulness of immunoglobulin G (IgG) subclasses against Candida cell wall fragments (CW) and phosphopeptidomannan (PPM) for the diagnosis of invasive candidiasis (IC). We analyzed 54 patients with IC (n = 19), Candida heavy colonization (HC; n = 16), and controls (no IC or HC, n = 19). In nonneutropenic patients (n = 47), the sensitivity and specificity values of IgG1 anti-CW and IgG2 anti-PPM in IC were 88%, 59%, and 88%, 94%, respectively. The areas under the receiver operating characteristic curves were 0.69 (0.51-0.88) and 0.901 (0.78-1.02), respectively. IgG1 mean values (arbitrary units) and 95% confidence interval were 46 (20-71), 42 (-0.38 to 84) and 20 (8.3-32) in IC, HC, and in controls, respectively, and discriminated IC but not HC from controls (P = .032, and P = .77, respectively). IgG2 mean values were 26 (9.2-42), 19 (4.4-33), and 3.2 (0.28-6.6) in IC, HC, and in controls, respectively, and discriminated both IC and HC from controls (P < .0001 and P = .035, respectively) but did not separate IC from HC (P = .2). IgG2 showed positivity as early as one day after the IC diagnosis. Antibodies were detected in only two out of a total of seven neutropenic patients. For both IC and HC patients, the diagnostic performance of IgG2 anti-PPM was better than the one of IgG1 anti-CW. In nonneutropenic patients, IgG2 anti-PPM accurately identified not only IC patients but also HC patients at high risk for IC. This marker may help clinicians in the initiation of early preemptive therapy.
Ämnesord och genrebeteckningar
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MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin hsv//swe
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MEDICAL AND HEALTH SCIENCES Clinical Medicine hsv//eng
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invasive candidiasis
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IgG subclass antibodies
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Candida albicans
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fungal infection
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intensive-care-unit
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ill surgical-patients
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beta-d-glucan
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neutropenic
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critically-ill
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3rd european conference
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antimannan antibodies
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systemic
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candidiasis
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fungal-infections
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hematological malignancies
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mannan
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antigen
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Infectious Diseases
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Mycology
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Veterinary Sciences
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Pinel, C.
(författare)
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Marcos, J.
(författare)
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Kondori, N.
(författare)
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Potton, L.
(författare)
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Thiebaut-Bertrand, A.
(författare)
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Pelloux, H.
(författare)
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Cornet, M.
(författare)
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Göteborgs universitetInstitutionen för biomedicin, avdelningen för infektionssjukdomar
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Medical Mycology: Oxford University Press (OUP)53:7, s. 725-7351369-37861460-2709
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