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IgG1 anti-cell wall...
IgG1 anti-cell wall and IgG2 anti-phosphopeptidomannan antibodies in the diagnosis of invasive candidiasis and heavy Candida colonization
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- Mattsby-Baltzer, Inger, 1949 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
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Pinel, C. (author)
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Marcos, J. (author)
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Kondori, N. (author)
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Potton, L. (author)
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Thiebaut-Bertrand, A. (author)
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Pelloux, H. (author)
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Cornet, M. (author)
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(creator_code:org_t)
- 2015-07-10
- 2015
- English.
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In: Medical Mycology. - : Oxford University Press (OUP). - 1369-3786 .- 1460-2709. ; 53:7, s. 725-735
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https://academic.oup...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- We conducted a retrospective study to evaluate the usefulness of immunoglobulin G (IgG) subclasses against Candida cell wall fragments (CW) and phosphopeptidomannan (PPM) for the diagnosis of invasive candidiasis (IC). We analyzed 54 patients with IC (n = 19), Candida heavy colonization (HC; n = 16), and controls (no IC or HC, n = 19). In nonneutropenic patients (n = 47), the sensitivity and specificity values of IgG1 anti-CW and IgG2 anti-PPM in IC were 88%, 59%, and 88%, 94%, respectively. The areas under the receiver operating characteristic curves were 0.69 (0.51-0.88) and 0.901 (0.78-1.02), respectively. IgG1 mean values (arbitrary units) and 95% confidence interval were 46 (20-71), 42 (-0.38 to 84) and 20 (8.3-32) in IC, HC, and in controls, respectively, and discriminated IC but not HC from controls (P = .032, and P = .77, respectively). IgG2 mean values were 26 (9.2-42), 19 (4.4-33), and 3.2 (0.28-6.6) in IC, HC, and in controls, respectively, and discriminated both IC and HC from controls (P < .0001 and P = .035, respectively) but did not separate IC from HC (P = .2). IgG2 showed positivity as early as one day after the IC diagnosis. Antibodies were detected in only two out of a total of seven neutropenic patients. For both IC and HC patients, the diagnostic performance of IgG2 anti-PPM was better than the one of IgG1 anti-CW. In nonneutropenic patients, IgG2 anti-PPM accurately identified not only IC patients but also HC patients at high risk for IC. This marker may help clinicians in the initiation of early preemptive therapy.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- invasive candidiasis
- IgG subclass antibodies
- Candida albicans
- fungal infection
- intensive-care-unit
- ill surgical-patients
- beta-d-glucan
- neutropenic
- critically-ill
- 3rd european conference
- antimannan antibodies
- systemic
- candidiasis
- fungal-infections
- hematological malignancies
- mannan
- antigen
- Infectious Diseases
- Mycology
- Veterinary Sciences
Publication and Content Type
- ref (subject category)
- art (subject category)
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