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Evolving Evidence f...
Evolving Evidence for the Value of Neuroimaging Methods and Biological Markers in Subjects Categorized with Subjective Cognitive Decline
- Article/chapterEnglish2015
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LIBRIS-ID:oai:gup.ub.gu.se/224867
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https://gup.ub.gu.se/publication/224867URI
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https://doi.org/10.3233/jad-150202DOI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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There is evolving evidence that individuals categorized with subjective cognitive decline (SCD) are potentially at higher risk for developing objective and progressive cognitive impairment compared to cognitively healthy individuals without apparent subjective complaints. Interestingly, SCD, during advancing preclinical Alzheimer's disease (AD), may denote very early, subtle cognitive decline that cannot be identified using established standardized tests of cognitive performance. The substantial heterogeneity of existing SCD-related research data has led the Subjective Cognitive Decline Initiative (SCD-I) to accomplish an international consensus on the definition of a conceptual research framework on SCD in preclinical AD. In the area of biological markers, the cerebrospinal fluid signature of AD has been reported to be more prevalent in subjects with SCD compared to healthy controls; moreover, there is a pronounced atrophy, as demonstrated by magnetic resonance imaging, and an increased hypometabolism, as revealed by positron emission tomography, in characteristic brain regions affected by AD. In addition, SCD individuals carrying an apolipoprotein epsilon 4 allele are more likely to display AD-phenotypic alterations. The urgent requirement to detect and diagnose AD as early as possible has led to the critical examination of the diagnostic power of biological markers, neurophysiology, and neuroimaging methods for AD-related risk and clinical progression in individuals defined with SCD. Observational studies on the predictive value of SCD for developing AD may potentially be of practical value, and an evidence-based, validated, qualified, and fully operationalized concept may inform clinical diagnostic practice and guide earlier designs in future therapy trials.
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Molinuevo, J. L.
(author)
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Cavedo, E.
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Rami, L.
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Amouyel, P.
(author)
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Teipel, S. J.
(author)
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Garaci, F.
(author)
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Toschi, N.
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Habert, M. O.
(author)
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Blennow, Kaj,1958Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xbleka
(author)
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Zetterberg, Henrik,1973Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xzethe
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O'Bryant, S. E.
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Johnson, L.
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Galluzzi, S.
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Bokde, A. L. W.
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Broich, K.
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Herholz, K.
(author)
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Bakardjian, H.
(author)
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Dubois, B.
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Jessen, F.
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Carrillo, M. C.
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Aisen, P. S.
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Hampel, H.
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Göteborgs universitetInstitutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi
(creator_code:org_t)
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In:Journal of Alzheimers Disease: IOS Press481387-28771875-8908
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Lista, S.
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Molinuevo, J. L.
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Cavedo, E.
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Rami, L.
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Amouyel, P.
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Teipel, S. J.
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show more...
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Garaci, F.
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Toschi, N.
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Habert, M. O.
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Blennow, Kaj, 19 ...
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Zetterberg, Henr ...
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O'Bryant, S. E.
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Johnson, L.
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Galluzzi, S.
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Bokde, A. L. W.
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Broich, K.
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Herholz, K.
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Bakardjian, H.
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Dubois, B.
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Jessen, F.
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Carrillo, M. C.
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Aisen, P. S.
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Hampel, H.
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and Neurosciences
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University of Gothenburg