Bioceramic Implant Induces Bone Healing of Cranial Defects.

Autologous bone or inert alloplastic materials used in cranial reconstructions are techniques that are associated with resorption, infection, and implant exposure. As an alternative, a calcium phosphate-based implant was developed and previously shown to potentially stimulate bone growth. We here uncover evidence of induced bone formation in 2 patients. Histological examination 9 months postoperatively showed multinuclear cells in the central defect zone and bone ingrowth in the bone-implant border zone. An increased expression of bone-associated markers was detected. The other patient was investigated 50 months postoperatively. Histological examination revealed ceramic materials covered by vascularized compact bone. The bone regenerative effect induced by the implant may potentially improve long-term clinical outcome compared with conventional techniques, which needs to be verified in a clinical study.

Kihlström, LarsKarolinska Institutet (author)
Lundgren, KalleKarolinska Institutet (author)
Trobos, Margarita,1980Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap,Institute of Clinical Sciences, Department of Biomaterials,Univ Gothenburg, Sahlgrenska Acad, Inst Clin Sci, Dept Biomat, Gothenburg, Sweden.;Univ Gothenburg, Vinn Excellence Ctr Biomat & Cell Therapy, Biomatcell, Gothenburg, Sweden.(Swepub:gu)xtroma (author)
Engqvist, HåkanUppsala universitet,Tillämpad materialvetenskap(Swepub:uu)hakaengq (author)
Thomsen, Peter,1953Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap,Institute of Clinical Sciences, Department of Biomaterials,Univ Gothenburg, Sahlgrenska Acad, Inst Clin Sci, Dept Biomat, Gothenburg, Sweden.;Univ Gothenburg, Vinn Excellence Ctr Biomat & Cell Therapy, Biomatcell, Gothenburg, Sweden.(Swepub:gu)xthope (author)
Karolinska InstitutetInstitutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap (creator_code:org_t)

In:Plastic and reconstructive surgery. Global open: LIPPINCOTT WILLIAMS & WILKINS3:82169-7574

By the author/editor: Engstrand, Thoma ...; Kihlström, Lars; Lundgren, Kalle; Trobos, Margarit ...; Engqvist, Håkan; Thomsen, Peter, ...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Dentistry

By the university: University of Gothenburg; Uppsala University; Karolinska Institutet

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