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  • Martner, Anna,1979Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center (author)

NK cell expression of natural cytotoxicity receptors may determine relapse risk in older AML patients undergoing immunotherapy for remission maintenance.

  • Article/chapterEnglish2015

Publisher, publication year, extent ...

  • 2015-10-30
  • Impact Journals, LLC,2015
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/227424
  • https://gup.ub.gu.se/publication/227424URI
  • https://doi.org/10.18632/oncotarget.5559DOI

Supplementary language notes

  • Language:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • In a phase IV trial, eighty-four patients (age 18-79) with acute myeloid leukemia (AML) in first complete remission (CR) received cycles of immunotherapy with histamine dihydrochloride (HDC) and low-dose human recombinant interleukin-2 (IL-2) to prevent relapse in the post-consolidation phase. Aspects of natural killer (NK) cell biology were analyzed before and during immunotherapy with focus on outcome in older patients. In younger (<60 years old, n = 37) and older patients (>60 years old, n = 47), treatment with HDC/IL-2 resulted in an expansion of CD56bright and CD16+ NK cells in blood along with an increased NK cell expression of the natural cytotoxicity receptors (NCR) NKp30 and NKp46. In older patients, a high expression of NKp30 or NKp46 on CD16+ NK cells before and during therapy predicted leukemia-free and overall survival. These results suggest that NK cell functions determine relapse risk and survival in older AML patients and point to biomarkers of efficacy in protocols for remission maintenance.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Rydström, Anna,1976Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center(Swepub:gu)xrydsa (author)
  • Riise, Rebecca E,1987Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center(Swepub:gu)xriire (author)
  • Aurelius, Johan,1980Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition(Swepub:gu)xaurjo (author)
  • Brune, Mats,1950Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition(Swepub:gu)xbrunm (author)
  • Foà, Robin (author)
  • Hellstrand, Kristoffer,1956Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center(Swepub:gu)xhellk (author)
  • Bergh Thorén, Fredrik,1976Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center(Swepub:gu)xthofr (author)
  • Göteborgs universitetSahlgrenska Cancer Center (creator_code:org_t)

Related titles

  • In:Oncotarget: Impact Journals, LLC6:40, s. 42569-741949-2553

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