Search: WFRF:(Bradfield Jonathan P) >
Genome-wide associa...
Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index.
-
Felix, Janine F (author)
-
Bradfield, Jonathan P (author)
-
Monnereau, Claire (author)
-
show more...
-
van der Valk, Ralf J P (author)
-
Stergiakouli, Evie (author)
-
Chesi, Alessandra (author)
-
Gaillard, Romy (author)
-
Feenstra, Bjarke (author)
-
Thiering, Elisabeth (author)
-
Kreiner-Møller, Eskil (author)
-
Mahajan, Anubha (author)
-
Pitkänen, Niina (author)
-
Joro, Raimo (author)
-
Cavadino, Alana (author)
-
Huikari, Ville (author)
-
Franks, Steve (author)
-
Groen-Blokhuis, Maria M (author)
-
Cousminer, Diana L (author)
-
Marsh, Julie A (author)
-
Lehtimäki, Terho (author)
-
Curtin, John A (author)
-
Vioque, Jesus (author)
-
Ahluwalia, Tarunveer S (author)
-
Myhre, Ronny (author)
-
Price, Thomas S (author)
-
Vilor-Tejedor, Natalia (author)
-
Yengo, Loïc (author)
-
Grarup, Niels (author)
-
Ntalla, Ioanna (author)
-
Ang, Wei (author)
-
Atalay, Mustafa (author)
-
Bisgaard, Hans (author)
-
Blakemore, Alexandra I (author)
-
Bonnefond, Amelie (author)
-
Carstensen, Lisbeth (author)
-
Eriksson, Johan (author)
-
Flexeder, Claudia (author)
-
Franke, Lude (author)
-
Geller, Frank (author)
-
Geserick, Mandy (author)
-
Hartikainen, Anna-Liisa (author)
-
Haworth, Claire M A (author)
-
Hirschhorn, Joel N (author)
-
Hofman, Albert (author)
-
Holm, Jens-Christian (author)
-
Horikoshi, Momoko (author)
-
Hottenga, Jouke Jan (author)
-
Huang, Jinyan (author)
-
Kadarmideen, Haja N (author)
-
Kähönen, Mika (author)
-
Kiess, Wieland (author)
-
Lakka, Hanna-Maaria (author)
-
Lakka, Timo A (author)
-
Lewin, Alexandra M (author)
-
Liang, Liming (author)
-
Lyytikäinen, Leo-Pekka (author)
-
Ma, Baoshan (author)
-
Magnus, Per (author)
-
McCormack, Shana E (author)
-
McMahon, George (author)
-
Mentch, Frank D (author)
-
Middeldorp, Christel M (author)
-
Murray, Clare S (author)
-
Pahkala, Katja (author)
-
Pers, Tune H (author)
-
Pfäffle, Roland (author)
-
Postma, Dirkje S (author)
-
Power, Christine (author)
-
Simpson, Angela (author)
-
- Sengpiel, Verena, 1977 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology
-
Tiesler, Carla M T (author)
-
Torrent, Maties (author)
-
Uitterlinden, André G (author)
-
van Meurs, Joyce B (author)
-
Vinding, Rebecca (author)
-
Waage, Johannes (author)
-
Wardle, Jane (author)
-
Zeggini, Eleftheria (author)
-
Zemel, Babette S (author)
-
Dedoussis, George V (author)
-
Pedersen, Oluf (author)
-
Froguel, Philippe (author)
-
Sunyer, Jordi (author)
-
Plomin, Robert (author)
-
- Jacobsson, Bo, 1960 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology
-
Hansen, Torben (author)
-
Gonzalez, Juan R (author)
-
Custovic, Adnan (author)
-
Raitakari, Olli T (author)
-
Pennell, Craig E (author)
-
Widén, Elisabeth (author)
-
Boomsma, Dorret I (author)
-
Koppelman, Gerard H (author)
-
Sebert, Sylvain (author)
-
Järvelin, Marjo-Riitta (author)
-
Hyppönen, Elina (author)
-
McCarthy, Mark I (author)
-
Lindi, Virpi (author)
-
Harri, Niinikoski (author)
-
Körner, Antje (author)
-
Bønnelykke, Klaus (author)
-
Heinrich, Joachim (author)
-
Melbye, Mads (author)
-
Rivadeneira, Fernando (author)
-
Hakonarson, Hakon (author)
-
Ring, Susan M (author)
-
Smith, George Davey (author)
-
Sørensen, Thorkild I A (author)
-
Timpson, Nicholas J (author)
-
Grant, Struan F A (author)
-
Jaddoe, Vincent W V (author)
-
show less...
-
(creator_code:org_t)
- 2015-11-24
- 2016
- English.
-
In: Human molecular genetics. - : Oxford University Press (OUP). - 1460-2083 .- 0964-6906. ; 25:2, s. 389-403
- Related links:
-
https://academic.oup...
-
show more...
-
https://gup.ub.gu.se...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- A large number of genetic loci are associated with adult body mass index. However, the genetics of childhood body mass index are largely unknown. We performed a meta-analysis of genome-wide association studies of childhood body mass index, using sex- and age-adjusted standard deviation scores. We included 35 668 children from 20 studies in the discovery phase and 11 873 children from 13 studies in the replication phase. In total, 15 loci reached genome-wide significance (P-value < 5 × 10(-8)) in the joint discovery and replication analysis, of which 12 are previously identified loci in or close to ADCY3, GNPDA2, TMEM18, SEC16B, FAIM2, FTO, TFAP2B, TNNI3K, MC4R, GPR61, LMX1B and OLFM4 associated with adult body mass index or childhood obesity. We identified three novel loci: rs13253111 near ELP3, rs8092503 near RAB27B and rs13387838 near ADAM23. Per additional risk allele, body mass index increased 0.04 Standard Deviation Score (SDS) [Standard Error (SE) 0.007], 0.05 SDS (SE 0.008) and 0.14 SDS (SE 0.025), for rs13253111, rs8092503 and rs13387838, respectively. A genetic risk score combining all 15 SNPs showed that each additional average risk allele was associated with a 0.073 SDS (SE 0.011, P-value = 3.12 × 10(-10)) increase in childhood body mass index in a population of 1955 children. This risk score explained 2% of the variance in childhood body mass index. This study highlights the shared genetic background between childhood and adult body mass index and adds three novel loci. These loci likely represent age-related differences in strength of the associations with body mass index.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Felix, Janine F
-
Bradfield, Jonat ...
-
Monnereau, Clair ...
-
van der Valk, Ra ...
-
Stergiakouli, Ev ...
-
Chesi, Alessandr ...
-
show more...
-
Gaillard, Romy
-
Feenstra, Bjarke
-
Thiering, Elisab ...
-
Kreiner-Møller, ...
-
Mahajan, Anubha
-
Pitkänen, Niina
-
Joro, Raimo
-
Cavadino, Alana
-
Huikari, Ville
-
Franks, Steve
-
Groen-Blokhuis, ...
-
Cousminer, Diana ...
-
Marsh, Julie A
-
Lehtimäki, Terho
-
Curtin, John A
-
Vioque, Jesus
-
Ahluwalia, Tarun ...
-
Myhre, Ronny
-
Price, Thomas S
-
Vilor-Tejedor, N ...
-
Yengo, Loïc
-
Grarup, Niels
-
Ntalla, Ioanna
-
Ang, Wei
-
Atalay, Mustafa
-
Bisgaard, Hans
-
Blakemore, Alexa ...
-
Bonnefond, Ameli ...
-
Carstensen, Lisb ...
-
Eriksson, Johan
-
Flexeder, Claudi ...
-
Franke, Lude
-
Geller, Frank
-
Geserick, Mandy
-
Hartikainen, Ann ...
-
Haworth, Claire ...
-
Hirschhorn, Joel ...
-
Hofman, Albert
-
Holm, Jens-Chris ...
-
Horikoshi, Momok ...
-
Hottenga, Jouke ...
-
Huang, Jinyan
-
Kadarmideen, Haj ...
-
Kähönen, Mika
-
Kiess, Wieland
-
Lakka, Hanna-Maa ...
-
Lakka, Timo A
-
Lewin, Alexandra ...
-
Liang, Liming
-
Lyytikäinen, Leo ...
-
Ma, Baoshan
-
Magnus, Per
-
McCormack, Shana ...
-
McMahon, George
-
Mentch, Frank D
-
Middeldorp, Chri ...
-
Murray, Clare S
-
Pahkala, Katja
-
Pers, Tune H
-
Pfäffle, Roland
-
Postma, Dirkje S
-
Power, Christine
-
Simpson, Angela
-
Sengpiel, Verena ...
-
Tiesler, Carla M ...
-
Torrent, Maties
-
Uitterlinden, An ...
-
van Meurs, Joyce ...
-
Vinding, Rebecca
-
Waage, Johannes
-
Wardle, Jane
-
Zeggini, Elefthe ...
-
Zemel, Babette S
-
Dedoussis, Georg ...
-
Pedersen, Oluf
-
Froguel, Philipp ...
-
Sunyer, Jordi
-
Plomin, Robert
-
Jacobsson, Bo, 1 ...
-
Hansen, Torben
-
Gonzalez, Juan R
-
Custovic, Adnan
-
Raitakari, Olli ...
-
Pennell, Craig E
-
Widén, Elisabeth
-
Boomsma, Dorret ...
-
Koppelman, Gerar ...
-
Sebert, Sylvain
-
Järvelin, Marjo- ...
-
Hyppönen, Elina
-
McCarthy, Mark I
-
Lindi, Virpi
-
Harri, Niinikosk ...
-
Körner, Antje
-
Bønnelykke, Klau ...
-
Heinrich, Joachi ...
-
Melbye, Mads
-
Rivadeneira, Fer ...
-
Hakonarson, Hako ...
-
Ring, Susan M
-
Smith, George Da ...
-
Sørensen, Thorki ...
-
Timpson, Nichola ...
-
Grant, Struan F ...
-
Jaddoe, Vincent ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Clinical Laborat ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Obstetrics Gynae ...
- Articles in the publication
-
Human molecular ...
- By the university
-
University of Gothenburg