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Cataract after allo...
Cataract after allogeneic hematopoietic stem cell transplantation in childhood
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- Teär Fahnehjelm, Kristina (author)
- Gothenburg University,Göteborgs universitet,Karolinska Institutet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation
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- Tornquist, A. L. (author)
- Department of Clinical Neuroscience, Karolinska Institutet, St Erik Eye Hospital, Karolinska University Hospital, Huddinge, Stockholm, Sweden
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- Olsson, M. (author)
- Karolinska Institutet
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- Bäckström, Ingrid (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology,Institute of Neuroscience and Physiology/Ophthalmology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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- Grönlund, Marita Andersson, 1959 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation,Institute of Neuroscience and Physiology/Ophthalmology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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- Winiarski, J. (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2015-12-22
- 2016
- English.
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In: Acta Paediatrica. - : Wiley. - 0803-5253 .- 1651-2227. ; 105:1, s. 82-89
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Abstract
Subject headings
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- AimThe aim of this study was to study long-term visual outcome and cataract development in children and adolescents after hematopoietic stem cell transplantation (HSCT) in childhood. MethodsBest corrected visual acuity (BCVA), refraction and lens status were examined in a prospective study of 139 children and adolescents. ResultsIn total, 139 patients (58 female), median age 6.6years at HSCT (range 0.4-17.5years), were followed up for a median of 8.0years (1-19.4years). Median BCVA in the better eye was 1.0 decimal. Altogether 19 of 131 patients developed cataract requiring surgery, while 46 developed less prominent lens opacities and 66 had clear lenses at time of latest follow-up. Patients conditioned with total body irradiation had a higher risk of developing lens opacities or cataract (p<0.0001) as did patients with malignant disease, irrespective of irradiation treatment (p<0.0001). Cumulative analysis showed that 50% of all patients had developed lens opacities/cataract after 10.2years. Patients who ultimately needed cataract surgery developed cataract earlier than others (p=0.006). ConclusionLens opacities or cataract were more common in children or adolescents with malignant disease and after conditioning with irradiation. Regular ophthalmological follow-up is important after HSCT for early intervention to avoid amblyopia.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Oftalmologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Ophthalmology (hsv//eng)
Keyword
- Cataract
- Hematopoietic stem cell transplantation
- Total body irradiation
- Visual outcome
- BONE-MARROW-TRANSPLANTATION
- TOTAL-BODY IRRADIATION
- VERSUS-HOST-DISEASE
- QUALITY-OF-LIFE
- OCULAR COMPLICATIONS
- CHILDREN
- SURVIVORS
- Cataract
Publication and Content Type
- ref (subject category)
- art (subject category)
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