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  • Mancina, Rosellina MargheritaUniversity of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine (author)

The MBOAT7-TMC4 Variant rs641738 Increases Risk of Nonalcoholic Fatty Liver Disease in Individuals of European Descent.

  • Article/chapterEnglish2016

Publisher, publication year, extent ...

  • Elsevier BV,2016

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/232892
  • https://gup.ub.gu.se/publication/232892URI
  • https://doi.org/10.1053/j.gastro.2016.01.032DOI
  • https://lup.lub.lu.se/record/8829121URI

Supplementary language notes

  • Language:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Nonalcoholic fatty liver disease (NAFLD) is a leading cause of liver damage and is characterized by steatosis. Genetic factors increase risk for progressive NAFLD. A genome-wide association study showed that the rs641738 C>T variant in the locus that contains the membrane bound O-acyltransferase domain-containing 7 gene (MBOAT7, also called LPIAT1) and transmembrane channel-like 4 gene (TMC4) increased the risk for cirrhosis in alcohol abusers. We investigated whether the MBOAT7-TMC4 is a susceptibility locus for the development and progression of NAFLD.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Dongiovanni, PaolaMaggiore Hospital Policlinico (author)
  • Petta, SalvatoreUniversity of Palermo (author)
  • Pingitore, Piero,1986University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xpinpi (author)
  • Meroni, MaricaUniversity of Milan (author)
  • Rametta, RaffaelaUniversity of Gothenburg (author)
  • Borén, Jan,1963University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xborej (author)
  • Montalcini, TizianaUniversity Magna Graecia (author)
  • Pujia, ArturoUniversity Magna Graecia (author)
  • Wiklund, Olov,1943Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Sahlgrenska University Hospital(Swepub:gu)xwikol (author)
  • Hindy, GeorgeLund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups(Swepub:lu)med-ghu (author)
  • Spagnuolo, Rocco (author)
  • Motta, Benedetta MariaGothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine (author)
  • Pipitone, Rosaria Maria (author)
  • Craxì, Antonio (author)
  • Fargion, Silvia (author)
  • Nobili, Valerio (author)
  • Käkelä, Pirjo (author)
  • Kärjä, Vesa (author)
  • Männistö, Ville (author)
  • Pihlajamäki, Jussi (author)
  • Reilly, Dermot F (author)
  • Castro-Perez, Jose (author)
  • Kozlitina, Julia (author)
  • Valenti, Luca (author)
  • Romeo, Stefano,1976Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xroste (author)
  • Göteborgs universitetInstitutionen för medicin, avdelningen för molekylär och klinisk medicin (creator_code:org_t)

Related titles

  • In:Gastroenterology: Elsevier BV150:5, s. 1219-12301528-00120016-5085

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