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Dynamics of cytotox...
Dynamics of cytotoxic T cell subsets during immunotherapy predicts outcome in acute myeloid leukemia
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- Sander, Frida Ewald (author)
- Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center,University of Gothenburg
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- Rydström, Anna, 1976 (author)
- Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center,University of Gothenburg
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- Bernson, Elin, 1987 (author)
- Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center,University of Gothenburg
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- Kiffin, Roberta (author)
- Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center,University of Gothenburg
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- Riise, Rebecca E, 1987 (author)
- Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center,University of Gothenburg
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- Aurelius, Johan, 1980 (author)
- Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,University of Gothenburg
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- Anderson, Harald (author)
- Lund University,Lunds universitet,Medicinsk onkologi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medical oncology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Brune, Mats, 1950 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,University of Gothenburg
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Foa, R. (author)
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- Hellstrand, Kristoffer, 1956 (author)
- Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center,University of Gothenburg
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- Bergh Thorén, Fredrik, 1976 (author)
- Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center,University of Gothenburg
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- Martner, Anna, 1979 (author)
- Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center,University of Gothenburg
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(creator_code:org_t)
- 2016-02-05
- 2016
- English.
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In: Oncotarget. - : Impact Journals, LLC. - 1949-2553. ; 7:7, s. 7586-7596
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Abstract
Subject headings
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- Preventing relapse after chemotherapy remains a challenge in acute myeloid leukemia (AML). Eighty-four non-transplanted AML patients in first complete remission received relapse-preventive immunotherapy with histamine dihydrochloride and low-dose interleukin-2 in an international phase IV trial (ClinicalTrials.gov; NCT01347996). Blood samples were drawn during cycles of immunotherapy and analyzed for CD8(+) (cytotoxic) T cell phenotypes in blood. During the first cycle of therapy, a re-distribution of cytotoxic T cells was observed comprising a reduction of T effector memory cells and a concomitant increase of T effector cells. The dynamics of T cell subtypes during immunotherapy prognosticated relapse and survival, in particular among older patients and remained significantly predictive of clinical outcome after correction for potential confounders. Presence of CD8(+) T cells with specificity for leukemia-associated antigens identified patients with low relapse risk. Our results point to novel aspects of T cell-mediated immunosurveillance in AML and provide conceivable biomarkers in relapse-preventive immunotherapy.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Keyword
- acute myeloid leukemia
- immunotherapy
- cytotoxic T cells
- antigen-specific T cells
- Immunology and
- histamine dihydrochloride
- transplantation
- memory
- differentiation
- interleukin-2
- lymphocytes
- maintenance
- remission
- responses
- effector
- Oncology
- Cell Biology
- lymphocytes
Publication and Content Type
- ref (subject category)
- art (subject category)
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Oncotarget
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- By the author/editor
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Sander, Frida Ew ...
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Rydström, Anna, ...
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Bernson, Elin, 1 ...
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Kiffin, Roberta
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Riise, Rebecca E ...
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Aurelius, Johan, ...
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Anderson, Harald
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Brune, Mats, 195 ...
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Foa, R.
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Hellstrand, Kris ...
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Bergh Thorén, Fr ...
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Martner, Anna, 1 ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
- Articles in the publication
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Oncotarget
- By the university
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University of Gothenburg
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Chalmers University of Technology
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Lund University