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Cerebral white matt...
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van Westen, DanielleLund University,Lunds universitet,Diagnostisk radiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neuroradiologi,Forskargrupper vid Lunds universitet,Diagnostic Radiology, (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Neuroradiology,Lund University Research Groups,Lund University, Lund, Sweden; Skåne University Health Care, Lund, Sweden
(författare)
Cerebral white matter lesions - associations with A beta isoforms and amyloid PET
- Artikel/kapitelEngelska2016
Förlag, utgivningsår, omfång ...
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2016-02-09
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Springer Science and Business Media LLC,2016
Nummerbeteckningar
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LIBRIS-ID:oai:gup.ub.gu.se/233505
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https://gup.ub.gu.se/publication/233505URI
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https://doi.org/10.1038/srep20709DOI
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https://lup.lub.lu.se/record/8826129URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-162695URI
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Small vessel disease (SVD) and amyloid deposition may promote each other, with a potential association between SVD and altered production or clearance of beta-amyloid (A beta) affecting its cleavage products. We investigated the relationship between SVD, multiple isoforms of A beta in cerebrospinal fluid (CSF) and cortical A beta in 831 subjects with cognitive performance ranging from normal to Alzheimer's disease (AD) (the Swedish BioFINDER study). SVD was estimated as white matter lesions (WML) and lacunes. 18F-flutemetamol PET was performed in 321 subjects. Lower CSF levels of A beta 38 and A beta 40 were consistently associated with increased WML in all subgroups, while lower levels of CSF A beta 42 were associated with WML mainly in AD. CSF A beta 38 and A beta 40 were associated with regional WML in all regions, while CSF A beta 42 was associated with temporal WML only. A composite measure of 18F-flutemetamol uptake was not associated with WML, and regional 18F-flutemetamol uptake only with temporal WML. Lacunes were not associated with A beta isoforms nor 18F-flutemetamol uptake. Our results suggest that WML may be associated with alterations in the production or clearance of A beta species, particularly of A beta 38 and A beta 40. However, in AD cases, A beta 42 pathology might be associated with WML, especially in the temporal lobe.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Lindqvist, DanielLund University,Lunds universitet,Psykiatri, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Psychiatry (Lund),Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University, Lund, Sweden; Division of Psychiatry Skåne, Lund, Sweden(Swepub:lu)med-del
(författare)
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Blennow, Kaj,1958Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology,The Sahlgrenska Academy at University of Gothenburg, Mölndal, Sweden(Swepub:gu)xbleka
(författare)
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Minthon, LennartLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Lund University, Lund, Sweden; Skåne University Health Care, Lund, Sweden(Swepub:lu)psyk-lmi
(författare)
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Nägga, KatarinaLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Lund University, Lund, Sweden; Skåne University Health Care, Lund, Sweden(Swepub:liu)katna61
(författare)
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Stomrud, ErikLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Lund University, Lund, Sweden; Skåne University Health Care, Lund, Sweden(Swepub:lu)med-esr
(författare)
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Zetterberg, Henrik,1973Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology,The Sahlgrenska Academy at University of Gothenburg, Mölndal, Sweden; UCL Institute of Neurology, Queen Square, London, United Kingdom(Swepub:gu)xzethe
(författare)
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Hansson, OskarLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Lund University, Lund, Sweden; Skåne University Health Care, Lund, Sweden(Swepub:lu)mphy-ohn
(författare)
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Diagnostisk radiologi, LundSektion V
(creator_code:org_t)
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Ingår i:Scientific Reports: Springer Science and Business Media LLC6:207092045-2322
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