Using simple mathematical functions to simulate pathological structures--input for digital mammography clinical trial.

Ruschin, MarkLund University,Lunds universitet,Medicinsk strålningsfysik, Malmö,Forskargrupper vid Lunds universitet,Medical Radiation Physics, Malmö,Lund University Research Groups (författare)

In this study a set of structures has been simulated to represent a range of clinically relevant breast cancer mammographic lesions including solid tumours and microcalcifications. All structures have been created using simple random-based mathematical functions and have been inserted into a subset of digital mammography images at appropriate contrast levels into various regions of the breast, including dense fibroglandular and adipose tissue. These structures and their appearance in these clinical images were evaluated in terms of how realistic they looked. They will be used as the input to a large-scale clinical trial designed to examine the effect of significant dose reduction in digital mammography by comparing the detectability of such structures in images acquired at full and quarter automatic exposure control (AEC) dose level and in images with simulated noise levels in between.

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Radiologi och bildbehandling hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Radiology, Nuclear Medicine and Medical Imaging hsv//eng
Adipose Tissue
radiography
Breast
pathology
Breast Diseases
diagnosis
Breast Neoplasms
diagnosis
Clinical Trials as Topic
Computer Simulation
Female
Humans
Mammography
instrumentation
methods
Models
Statistical
Models
Theoretical
Radiographic Image Enhancement
Radiographic Image Interpretation
Computer-Assisted
methods
Software
X-Rays
adipose tissue
contrast level
fibroglandular tissue
random-based mathematical function
microcalcification
solid tumour
breast cancer mammographic lesion
pathological structure
digital mammography
noise level
automatic exposure control dose level
dose reduction
image acquisition

Tingberg, AndersLund University,Lunds universitet,Medicinsk strålningsfysik, Malmö,Forskargrupper vid Lunds universitet,Medical Radiation Physics, Malmö,Lund University Research Groups(Swepub:lu)rfa-ati (författare)
Båth, Magnus,1974Gothenburg University,Göteborgs universitet,Institutionen för särskilda specialiteter, Avdelningen för radiofysik,Institute of Selected Clinical Sciences, Department of Radiation Physics(Swepub:gu)xbatma (författare)
Grahn, AnnaLund University,Lunds universitet,Medicinsk strålningsfysik, Malmö,Forskargrupper vid Lunds universitet,Medical Radiation Physics, Malmö,Lund University Research Groups(Swepub:lu)rfa-abj (författare)
Håkansson, MarkusGothenburg University,Göteborgs universitet,Institutionen för särskilda specialiteter, Avdelningen för radiofysik,Institute of Selected Clinical Sciences, Department of Radiation Physics (författare)
Hemdal, BengtLund University,Lunds universitet,Medicinsk strålningsfysik, Malmö,Forskargrupper vid Lunds universitet,Medical Radiation Physics, Malmö,Lund University Research Groups(Swepub:lu)rfa-bhe (författare)
Andersson, I (författare)
Medicinsk strålningsfysik, MalmöForskargrupper vid Lunds universitet (creator_code:org_t)

Ingår i:Radiation protection dosimetry: Oxford University Press (OUP)114:1-3, s. 424-310144-84201742-3406

Av författaren/redakt...: Ruschin, Mark; Tingberg, Anders; Båth, Magnus, 19 ...; Grahn, Anna; Håkansson, Marku ...; Hemdal, Bengt; visa fler...; Andersson, I; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Radiologi och bi ...

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