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- Schöll, Michael,1980Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation (author)
PET Imaging of Tau Deposition in the Aging Human Brain
- Article/chapterEnglish2016
Publisher, publication year, extent ...
- Elsevier BV,2016
Numbers
- LIBRIS-ID:oai:gup.ub.gu.se/235825
- https://gup.ub.gu.se/publication/235825URI
- https://doi.org/10.1016/j.neuron.2016.01.028DOI
Supplementary language notes
- Language:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- Tau pathology is a hallmark of Alzheimer's disease (AD) but also occurs in normal cognitive aging. Using the tau PET agent F-18-AV-1451, we examined retention patterns in cognitively normal older people in relation to young controls and AD patients. Age and beta-amyloid (measured using PiB PET) were differentially associated with tau tracer retention in healthy aging. Older age was related to increased tracer retention in regions of the medial temporal lobe, which predicted worse episodic memory performance. PET detection of tau in other isocortical regions required the presence of cortical b-amyloid and was associated with decline in global cognition. Furthermore, patterns of tracer retention corresponded well with Braak staging of neurofibrillary tau pathology. The present study defined patterns of tau tracer retention in normal aging in relation to age, cognition, and beta-amyloid deposition.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Neurologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Neurology hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Neurovetenskaper hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Neurosciences hsv//eng
- mild cognitive impairment
- alzheimers-disease
- neurofibrillary tangles
- episodic memory
- cerebrospinal-fluid
- national institute
- age
- categories
- senile plaques
- amyloid-beta
- a-beta
- Neurosciences & Neurology
Added entries (persons, corporate bodies, meetings, titles ...)
- Lockhart, S. N. (author)
- Schonhaut, D. R. (author)
- O'Neil, J. P. (author)
- Janabi, M. (author)
- Ossenkoppele, R. (author)
- Baker, S. L. (author)
- Vogel, J. W. (author)
- Faria, J. (author)
- Schwimmer, H. D. (author)
- Rabinovici, G. D. (author)
- Jagust, W. J. (author)
- Göteborgs universitetInstitutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering (creator_code:org_t)
Related titles
- In:Neuron: Elsevier BV89:5, s. 971-9820896-6273
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- Baker, S. L.
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