When, How, and Where can Oral Cholera Vaccines be Used to Interrupt Cholera Outbreaks?

• Cholera continues to be a major global health problem, at times causing major and prolonged outbreaks in both endemic and nonendemic settings in developing countries. While improved water quality, sanitation, and hygiene (WASH) will provide the ultimate solution to prevention of this disease burden, this is a far-off goal for most developing countries. Oral cholera vaccines (OCVs) have been demonstrated to be effective in the control of cholera outbreaks, and constitute useful tools to be used in conjunction with efforts to improve WASH. Two killed OCVs are prequalified by WHO for purchase by UN agencies for international use. Recently, WHO has launched a global stockpile of killed OCVs for use to control outbreaks. Rational deployment of OCV from this stockpile will require consideration of costs, feasibility, disease epidemiology, and the protective characteristics of the vaccine deployed, as well as effective and rapid coordination of processes and logistics used to make decisions on deployment and delivery of the vaccine to the population in need. Despite not having data on all the questions of relevance as to how to use OCVs to control cholera outbreaks in different settings, there is clearly more than enough evidence to initiate their use, as answers to remaining questions and refinement of policies will mainly come with experience.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Health Sciences (hsv//eng)

Nyckelord

KILLED WHOLE-CELL

TOXIN-B-SUBUNIT

CVD 103-HGR

FIELD TRIAL

VACCINATION STRATEGIES

COST-EFFECTIVENESS

MASS VACCINATION

DEVELOPING-WORLD

IMMUNIZATION

BANGLADESH

Infectious Diseases

Microbiology

CKET CO

1992

JOURNAL OF INFECTIOUS DISEASES

V166

P837

B BC

1986

BULLETIN OF THE WORLD HEALTH ORGANIZATION

V64

P127

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)