id:"swepub:oai:gup.ub.gu.se/236990"
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- Wang, C. (author)
The toxic effects of microcystin-LR on mouse lungs and alveolar type II epithelial cells
- Article/chapterEnglish2016
Publisher, publication year, extent ...
- Elsevier BV,2016
Numbers
- LIBRIS-ID:oai:gup.ub.gu.se/236990
- https://gup.ub.gu.se/publication/236990URI
- https://doi.org/10.1016/j.toxicon.2016.03.007DOI
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- Language:English
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- SwePubSwePub
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- Objectives: Microcystin-leucine arginine (MC-LR) is produced by cyanobacteria and can accumulate in lungs through blood circulation. However, the effect of MC-LR on lung remains unclear. In this study, we investigated the chronic, low-dose effect of MC-LR on mouse lung tissues and the influence of MC-LR on mouse alveolar type II epithelial cells (ATII cells). Methods: MC-LR was orally administered to mice at 0, 1, 10, and 40 mu g/L for 6 consecutive months and mouse lungs were obtained for histopathological and immunoblot analysis. ATII cells were cultured in various concentrations of MC-LR (0, 0.5, 5, 50, 500 nmol/L) for indicated time and the cell viability and proteins change were tested. Results: Our study revealed that the chronic, low-dose MC-LR exposure induced alveolar collapse and lung cell apoptosis as well as the breach of cell junction integrity. Furthermore, following treatment with MC-LR, ATII cells could uptake MC-LR, resulting in apoptosis and disruption of cell junction integrity. Conclusions: These data support the toxic potential of low-dose MC-LR in rendering chronic injury to lung tissues.
Subject headings and genre
- NATURVETENSKAP Biologi hsv//swe
- NATURAL SCIENCES Biological Sciences hsv//eng
- Microcystin-LR
- Chronic low dose
- Lung
- Toxic
- mesenchymal transition
- inhibition
- mechanisms
- surfactant
- liver
- water
- line
- cyanotoxins
- metastasis
- activation
- Pharmacology & Pharmacy
- Toxicology
Added entries (persons, corporate bodies, meetings, titles ...)
- Gu, S. (author)
- Yin, X. Q. (author)
- Yuan, M. M. (author)
- Xiang, ZouGothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology(Swepub:gu)xxiazo (author)
- Li, Z. T. (author)
- Cao, H. H. (author)
- Meng, X. N. (author)
- Hu, K. B. (author)
- Han, X. D. (author)
- Göteborgs universitetInstitutionen för biomedicin, avdelningen för mikrobiologi och immunologi (creator_code:org_t)
Related titles
- In:Toxicon: Elsevier BV115, s. 81-880041-0101
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- Wang, C.
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- Yin, X. Q.
- Yuan, M. M.
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- Li, Z. T.
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- Cao, H. H.
- Meng, X. N.
- Hu, K. B.
- Han, X. D.
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- About the subject
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- NATURAL SCIENCES
- NATURAL SCIENCES
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- Toxicon
- By the university
- University of Gothenburg
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