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  • Cesta, C. E.Karolinska Institutet (författare)

Depression, anxiety, and antidepressant treatment in women: association with in vitro fertilization outcome

  • Artikel/kapitelEngelska2016

Förlag, utgivningsår, omfång ...

  • Elsevier BV,2016

Nummerbeteckningar

  • LIBRIS-ID:oai:gup.ub.gu.se/238896
  • https://gup.ub.gu.se/publication/238896URI
  • https://doi.org/10.1016/j.fertnstert.2016.01.036DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-279171URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-206307URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:133710034URI

Kompletterande språkuppgifter

  • Språk:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Objective: To investigate associations between depression, anxiety, and antidepressants before in vitro fertilization (1VF) and IVF cycle outcomes, including pregnancy, live birth, and miscarriage. Patient(s): Nulliparous women undergoing their first 1VF cycle recorded in the Swedish Quality Register of Assisted Reproduction, January 2007 to December 2012 (n = 23,557). Main Outcome Measure(s): Associations between diagnoses of depression/anxiety, antidepressants, and IVF cycle outcome evaluated using logistic regression to produce adjusted odds ratios (AOR) and 950/o confidence intervals (CI). Result(s): In total, 4.40/o of women had been diagnosed with depression/anxiety and/or dispensed antidepressants before their IVF first cycle. The odds for pregnancy and live birth were decreased (n = 1,044; AOR = 0.86; 950/0 CI, 0.75-0.98; and AOR = 0.83; 950/o CI, 0.720.96, respectively). For women with a prescription for a selective serotonin reuptake inhibitor (SSRI) only (n = 829), no statistically significant associations were found. Women with non-SSRI antidepressants (n = 52) were at reduced odds of pregnancy (AOR = 0.41; 950/0 CI, 0.21-0.80) and live birth (AOR = 0.27; 950/o CI, 0.11-0.68). Women with a depression/anxiety diagnosis with no antidepressant (n = 164) also had reduced odds of pregnancy (AOR = 0.58; 950/0 CI, 0.41-0.82) and live birth (AOR = 0.60; 95% CI, 0.41-0.89). Among the women who became pregnant (39.70/0, there were no statistically significant associations between exposure and miscarriage except for the women taking non-SSRI antidepressants (AOR = 3.56; 950/o CI, 1.06-11.9). Conclusion(s): A diagnosis of depression/anxiety and/or treatment with antidepressants before IVF was associated with slightly reduced odds of pregnancy and live birth. Women with the presence of depression/anxiety without antidepressants had a more pronounced reduction in odds, implying that the underlying disorder is important for the observed association.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Viktorin, A.Karolinska Institutet (författare)
  • Olsson, H.Karolinska Institutet (författare)
  • Johansson, ViktoriaKarolinska Institutet(Swepub:umu)vijo2972 (författare)
  • Sjolander, A.Karolinska Institutet (författare)
  • Bergh, Christina,1953Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology(Swepub:gu)xbechr (författare)
  • Skalkidou, AlkistisUppsala universitet,Obstetrik & gynekologi,Obstetrik(Swepub:uu)alksk607 (författare)
  • Nygren, K. G. (författare)
  • Cnattingius, S.Karolinska Institutet (författare)
  • Iliadou, A. N.Karolinska Institutet (författare)
  • Karolinska InstitutetInstitutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Fertility and Sterility: Elsevier BV105:60015-02821556-5653

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