Search: (WFRF:(Leboyer Marion)) srt2:(2015-2019) pers:(Rietschel Marcella) >
Genome-wide associa...
Genome-wide association study of 40,000 individuals identifies two novel loci associated with bipolar disorder.
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Hou, Liping (author)
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- Bergen, Sarah E (author)
- Karolinska Institutet
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Akula, Nirmala (author)
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show more...
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- Song, Jie (author)
- Karolinska Institutet
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- Hultman, Christina M (author)
- Karolinska Institutet
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- Landén, Mikael, 1966 (author)
- Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
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Adli, Mazda (author)
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Alda, Martin (author)
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Ardau, Raffaella (author)
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Arias, Bárbara (author)
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Aubry, Jean-Michel (author)
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- Backlund, Lena (author)
- Karolinska Institutet
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Badner, Judith A (author)
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Barrett, Thomas B (author)
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Bauer, Michael (author)
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Baune, Bernhard T (author)
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Bellivier, Frank (author)
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Benabarre, Antonio (author)
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Bengesser, Susanne (author)
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Berrettini, Wade H (author)
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Bhattacharjee, Abesh Kumar (author)
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Biernacka, Joanna M (author)
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Birner, Armin (author)
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Bloss, Cinnamon S (author)
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Brichant-Petitjean, Clara (author)
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Bui, Elise T (author)
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Byerley, William (author)
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Cervantes, Pablo (author)
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- Chillotti, Caterina (author)
- Karolinska Institutet
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Cichon, Sven (author)
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Colom, Francesc (author)
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Coryell, William (author)
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Craig, David W (author)
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Cruceanu, Cristiana (author)
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Czerski, Piotr M (author)
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Davis, Tony (author)
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Dayer, Alexandre (author)
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Degenhardt, Franziska (author)
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Del Zompo, Maria (author)
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DePaulo, J Raymond (author)
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Edenberg, Howard J (author)
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Étain, Bruno (author)
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Falkai, Peter (author)
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Foroud, Tatiana (author)
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Forstner, Andreas J (author)
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- Frisén, Louise (author)
- Karolinska Institutet
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Frye, Mark A (author)
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Fullerton, Janice M (author)
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Gard, Sébastien (author)
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Garnham, Julie S (author)
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Gershon, Elliot S (author)
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Goes, Fernando S (author)
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Greenwood, Tiffany A (author)
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Grigoroiu-Serbanescu, Maria (author)
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Hauser, Joanna (author)
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Heilbronner, Urs (author)
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Heilmann-Heimbach, Stefanie (author)
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Herms, Stefan (author)
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Hipolito, Maria (author)
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Hitturlingappa, Shashi (author)
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Hoffmann, Per (author)
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Hofmann, Andrea (author)
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Jamain, Stephane (author)
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Jiménez, Esther (author)
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Kahn, Jean-Pierre (author)
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Kassem, Layla (author)
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Kelsoe, John R (author)
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Kittel-Schneider, Sarah (author)
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Kliwicki, Sebastian (author)
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Koller, Daniel L (author)
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König, Barbara (author)
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Lackner, Nina (author)
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Laje, Gonzalo (author)
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Lang, Maren (author)
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Lavebratt, Catharina (author)
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Lawson, William B (author)
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Leboyer, Marion (author)
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Leckband, Susan G (author)
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Liu, Chunyu (author)
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Maaser, Anna (author)
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Mahon, Pamela B (author)
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Maier, Wolfgang (author)
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- Maj, Mario (author)
- Karolinska Institutet
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Manchia, Mirko (author)
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- Martinsson, Lina (author)
- Karolinska Institutet
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McCarthy, Michael J (author)
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McElroy, Susan L (author)
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McInnis, Melvin G (author)
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McKinney, Rebecca (author)
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Mitchell, Philip B (author)
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Mitjans, Marina (author)
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Mondimore, Francis M (author)
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Monteleone, Palmiero (author)
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Mühleisen, Thomas W (author)
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Nievergelt, Caroline M (author)
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Nöthen, Markus M (author)
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Novák, Tomas (author)
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Nurnberger, John I (author)
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Nwulia, Evaristus A (author)
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Ösby, Urban (author)
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Pfennig, Andrea (author)
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Potash, James B (author)
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Propping, Peter (author)
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Reif, Andreas (author)
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Reininghaus, Eva (author)
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Rice, John (author)
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Rietschel, Marcella (author)
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Rouleau, Guy A (author)
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Rybakowski, Janusz K (author)
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Schalling, Martin (author)
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Scheftner, William A (author)
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Schofield, Peter R (author)
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Schork, Nicholas J (author)
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Schulze, Thomas G (author)
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Schumacher, Johannes (author)
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Schweizer, Barbara W (author)
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Severino, Giovanni (author)
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Shekhtman, Tatyana (author)
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Shilling, Paul D (author)
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Simhandl, Christian (author)
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Slaney, Claire M (author)
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Smith, Erin N (author)
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Squassina, Alessio (author)
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Stamm, Thomas (author)
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Stopkova, Pavla (author)
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Streit, Fabian (author)
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Strohmaier, Jana (author)
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Szelinger, Szabolcs (author)
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Tighe, Sarah K (author)
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Tortorella, Alfonso (author)
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Turecki, Gustavo (author)
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Vieta, Eduard (author)
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Volkert, Julia (author)
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Witt, Stephanie H (author)
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Wright, Adam (author)
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Zandi, Peter P (author)
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Zhang, Peng (author)
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Zollner, Sebastian (author)
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McMahon, Francis J (author)
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(creator_code:org_t)
- 2016-06-21
- 2016
- English.
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In: Human molecular genetics. - : Oxford University Press (OUP). - 1460-2083 .- 0964-6906. ; 25:15, s. 3383-94
- Related links:
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https://academic.oup...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Subject headings
Close
- Bipolar disorder (BD) is a genetically complex mental illness characterized by severe oscillations of mood and behavior. Genome-wide association studies (GWAS) have identified several risk loci that together account for a small portion of the heritability. To identify additional risk loci, we performed a two-stage meta-analysis of >9 million genetic variants in 9,784 bipolar disorder patients and 30,471 controls, the largest GWAS of BD to date. In this study, to increase power we used ∼2,000 lithium-treated cases with a long-term diagnosis of BD from the Consortium on Lithium Genetics, excess controls, and analytic methods optimized for markers on the X-chromosome. In addition to four known loci, results revealed genome-wide significant associations at two novel loci: an intergenic region on 9p21.3 (rs12553324, p=5.87×10(-9); odds ratio=1.12) and markers within ERBB2 (rs2517959, p=4.53×10(-9); odds ratio=1.13). No significant X-chromosome associations were detected and X-linked markers explained very little BD heritability. The results add to a growing list of common autosomal variants involved in BD and illustrate the power of comparing well-characterized cases to an excess of controls in GWAS.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Hou, Liping
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Bergen, Sarah E
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Akula, Nirmala
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Song, Jie
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Hultman, Christi ...
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Landén, Mikael, ...
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show more...
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Adli, Mazda
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Alda, Martin
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Ardau, Raffaella
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Arias, Bárbara
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Aubry, Jean-Mich ...
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Backlund, Lena
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Badner, Judith A
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Barrett, Thomas ...
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Bauer, Michael
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Baune, Bernhard ...
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Bellivier, Frank
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Benabarre, Anton ...
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Bengesser, Susan ...
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Berrettini, Wade ...
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Bhattacharjee, A ...
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Biernacka, Joann ...
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Birner, Armin
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Bloss, Cinnamon ...
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Brichant-Petitje ...
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Bui, Elise T
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Byerley, William
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Cervantes, Pablo
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Chillotti, Cater ...
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Cichon, Sven
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Colom, Francesc
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Coryell, William
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Craig, David W
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Cruceanu, Cristi ...
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Czerski, Piotr M
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Davis, Tony
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Dayer, Alexandre
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Degenhardt, Fran ...
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Del Zompo, Maria
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DePaulo, J Raymo ...
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Edenberg, Howard ...
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Étain, Bruno
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Falkai, Peter
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Foroud, Tatiana
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Forstner, Andrea ...
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Frisén, Louise
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Frye, Mark A
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Fullerton, Janic ...
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Gard, Sébastien
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Garnham, Julie S
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Gershon, Elliot ...
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Goes, Fernando S
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Greenwood, Tiffa ...
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Grigoroiu-Serban ...
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Hauser, Joanna
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Heilbronner, Urs
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Heilmann-Heimbac ...
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Herms, Stefan
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Hipolito, Maria
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Hitturlingappa, ...
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Hoffmann, Per
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Hofmann, Andrea
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Jamain, Stephane
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Jiménez, Esther
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Kahn, Jean-Pierr ...
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Kassem, Layla
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Kelsoe, John R
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Kittel-Schneider ...
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Kliwicki, Sebast ...
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Koller, Daniel L
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König, Barbara
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Lackner, Nina
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Laje, Gonzalo
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Lang, Maren
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Lavebratt, Catha ...
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Lawson, William ...
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Leboyer, Marion
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Leckband, Susan ...
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Liu, Chunyu
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Maaser, Anna
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Mahon, Pamela B
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Maier, Wolfgang
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Maj, Mario
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Manchia, Mirko
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Martinsson, Lina
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McCarthy, Michae ...
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McElroy, Susan L
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McInnis, Melvin ...
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McKinney, Rebecc ...
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Mitchell, Philip ...
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Mitjans, Marina
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Mondimore, Franc ...
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Monteleone, Palm ...
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Mühleisen, Thoma ...
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Nievergelt, Caro ...
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Nöthen, Markus M
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Novák, Tomas
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Nurnberger, John ...
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Nwulia, Evaristu ...
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Ösby, Urban
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Pfennig, Andrea
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Potash, James B
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Propping, Peter
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Reif, Andreas
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Reininghaus, Eva
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Rice, John
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Rietschel, Marce ...
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Rouleau, Guy A
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Rybakowski, Janu ...
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Schalling, Marti ...
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Scheftner, Willi ...
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Schofield, Peter ...
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Schork, Nicholas ...
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Schulze, Thomas ...
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Schumacher, Joha ...
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Schweizer, Barba ...
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Severino, Giovan ...
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Shekhtman, Tatya ...
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Shilling, Paul D
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Simhandl, Christ ...
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Slaney, Claire M
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Smith, Erin N
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Squassina, Aless ...
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Stamm, Thomas
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Stopkova, Pavla
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Streit, Fabian
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Strohmaier, Jana
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Szelinger, Szabo ...
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Tighe, Sarah K
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Tortorella, Alfo ...
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Turecki, Gustavo
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Vieta, Eduard
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Volkert, Julia
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Witt, Stephanie ...
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Wright, Adam
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Zandi, Peter P
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Zhang, Peng
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Zollner, Sebasti ...
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McMahon, Francis ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Psychiatry
- Articles in the publication
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Human molecular ...
- By the university
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University of Gothenburg
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Karolinska Institutet