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Genome-wide associa...
Genome-wide association study of 40,000 individuals identifies two novel loci associated with bipolar disorder.
- Article/chapterEnglish2016
Publisher, publication year, extent ...
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2016-06-21
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Oxford University Press (OUP),2016
Numbers
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LIBRIS-ID:oai:gup.ub.gu.se/239372
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https://gup.ub.gu.se/publication/239372URI
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https://doi.org/10.1093/hmg/ddw181DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:135089540URI
Supplementary language notes
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Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Bipolar disorder (BD) is a genetically complex mental illness characterized by severe oscillations of mood and behavior. Genome-wide association studies (GWAS) have identified several risk loci that together account for a small portion of the heritability. To identify additional risk loci, we performed a two-stage meta-analysis of >9 million genetic variants in 9,784 bipolar disorder patients and 30,471 controls, the largest GWAS of BD to date. In this study, to increase power we used ∼2,000 lithium-treated cases with a long-term diagnosis of BD from the Consortium on Lithium Genetics, excess controls, and analytic methods optimized for markers on the X-chromosome. In addition to four known loci, results revealed genome-wide significant associations at two novel loci: an intergenic region on 9p21.3 (rs12553324, p=5.87×10(-9); odds ratio=1.12) and markers within ERBB2 (rs2517959, p=4.53×10(-9); odds ratio=1.13). No significant X-chromosome associations were detected and X-linked markers explained very little BD heritability. The results add to a growing list of common autosomal variants involved in BD and illustrate the power of comparing well-characterized cases to an excess of controls in GWAS.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Bergen, Sarah EKarolinska Institutet
(author)
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Akula, Nirmala
(author)
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Song, JieKarolinska Institutet
(author)
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Hultman, Christina MKarolinska Institutet
(author)
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Landén, Mikael,1966Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology(Swepub:gu)xlandt
(author)
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Adli, Mazda
(author)
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Alda, Martin
(author)
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Ardau, Raffaella
(author)
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Arias, Bárbara
(author)
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Aubry, Jean-Michel
(author)
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Backlund, LenaKarolinska Institutet
(author)
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Badner, Judith A
(author)
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Barrett, Thomas B
(author)
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Bauer, Michael
(author)
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Baune, Bernhard T
(author)
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Bellivier, Frank
(author)
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Benabarre, Antonio
(author)
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Bengesser, Susanne
(author)
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Berrettini, Wade H
(author)
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Bhattacharjee, Abesh Kumar
(author)
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Biernacka, Joanna M
(author)
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Birner, Armin
(author)
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Bloss, Cinnamon S
(author)
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Brichant-Petitjean, Clara
(author)
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Bui, Elise T
(author)
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Byerley, William
(author)
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Cervantes, Pablo
(author)
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Chillotti, CaterinaKarolinska Institutet
(author)
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Cichon, Sven
(author)
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Colom, Francesc
(author)
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Coryell, William
(author)
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Craig, David W
(author)
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Cruceanu, Cristiana
(author)
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Czerski, Piotr M
(author)
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Davis, Tony
(author)
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Dayer, Alexandre
(author)
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Degenhardt, Franziska
(author)
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Del Zompo, Maria
(author)
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DePaulo, J Raymond
(author)
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Edenberg, Howard J
(author)
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Étain, Bruno
(author)
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Falkai, Peter
(author)
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Foroud, Tatiana
(author)
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Forstner, Andreas J
(author)
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Frisén, LouiseKarolinska Institutet
(author)
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Frye, Mark A
(author)
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Fullerton, Janice M
(author)
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Gard, Sébastien
(author)
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Garnham, Julie S
(author)
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Gershon, Elliot S
(author)
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Goes, Fernando S
(author)
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Greenwood, Tiffany A
(author)
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Grigoroiu-Serbanescu, Maria
(author)
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Hauser, Joanna
(author)
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Heilbronner, Urs
(author)
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Heilmann-Heimbach, Stefanie
(author)
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Herms, Stefan
(author)
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Hipolito, Maria
(author)
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Hitturlingappa, Shashi
(author)
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Hoffmann, Per
(author)
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Hofmann, Andrea
(author)
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Jamain, Stephane
(author)
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Jiménez, Esther
(author)
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Kahn, Jean-Pierre
(author)
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Kassem, Layla
(author)
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Kelsoe, John R
(author)
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Kittel-Schneider, Sarah
(author)
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Kliwicki, Sebastian
(author)
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Koller, Daniel L
(author)
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König, Barbara
(author)
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Lackner, Nina
(author)
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Laje, Gonzalo
(author)
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Lang, Maren
(author)
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Lavebratt, Catharina
(author)
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Lawson, William B
(author)
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Leboyer, Marion
(author)
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Leckband, Susan G
(author)
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Liu, Chunyu
(author)
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Maaser, Anna
(author)
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Mahon, Pamela B
(author)
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Maier, Wolfgang
(author)
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Maj, MarioKarolinska Institutet
(author)
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Manchia, Mirko
(author)
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Martinsson, LinaKarolinska Institutet
(author)
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McCarthy, Michael J
(author)
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McElroy, Susan L
(author)
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McInnis, Melvin G
(author)
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McKinney, Rebecca
(author)
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Mitchell, Philip B
(author)
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Mitjans, Marina
(author)
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Mondimore, Francis M
(author)
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Monteleone, Palmiero
(author)
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Mühleisen, Thomas W
(author)
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Nievergelt, Caroline M
(author)
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Nöthen, Markus M
(author)
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Novák, Tomas
(author)
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Nurnberger, John I
(author)
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Nwulia, Evaristus A
(author)
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Ösby, Urban
(author)
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Pfennig, Andrea
(author)
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Potash, James B
(author)
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Propping, Peter
(author)
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Reif, Andreas
(author)
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Reininghaus, Eva
(author)
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Rice, John
(author)
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Rietschel, Marcella
(author)
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Rouleau, Guy A
(author)
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Rybakowski, Janusz K
(author)
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Schalling, Martin
(author)
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Scheftner, William A
(author)
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Schofield, Peter R
(author)
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Schork, Nicholas J
(author)
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Schulze, Thomas G
(author)
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Schumacher, Johannes
(author)
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Schweizer, Barbara W
(author)
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Severino, Giovanni
(author)
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Shekhtman, Tatyana
(author)
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Shilling, Paul D
(author)
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Simhandl, Christian
(author)
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Slaney, Claire M
(author)
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Smith, Erin N
(author)
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Squassina, Alessio
(author)
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Stamm, Thomas
(author)
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Stopkova, Pavla
(author)
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Streit, Fabian
(author)
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Strohmaier, Jana
(author)
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Szelinger, Szabolcs
(author)
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Tighe, Sarah K
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Tortorella, Alfonso
(author)
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Turecki, Gustavo
(author)
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Vieta, Eduard
(author)
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Volkert, Julia
(author)
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Witt, Stephanie H
(author)
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Wright, Adam
(author)
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Zandi, Peter P
(author)
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Zhang, Peng
(author)
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Zollner, Sebastian
(author)
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McMahon, Francis J
(author)
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Karolinska InstitutetInstitutionen för neurovetenskap och fysiologi
(creator_code:org_t)
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In:Human molecular genetics: Oxford University Press (OUP)25:15, s. 3383-941460-20830964-6906
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- MEDICAL AND HEALTH SCIENCES
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Human molecular ...
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University of Gothenburg
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Karolinska Institutet