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PNPLA3 148M Carrier...
PNPLA3 148M Carriers with Inflammatory Bowel Diseases Have Higher Susceptibility to Hepatic Steatosis and Higher Liver Enzymes
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- Mancina, Rosellina Margherita (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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Spagnuolo, R. (author)
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Milano, M. (author)
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Brogneri, S. (author)
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Morrone, A. (author)
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Cosco, C. (author)
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Lazzaro, V. (author)
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Russo, C. (author)
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Ferro, Y. (author)
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- Pingitore, Piero, 1986 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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Pujia, A. (author)
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Montalcini, T. (author)
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Doldo, P. (author)
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Garieri, P. (author)
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Piodi, L. (author)
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Caprioli, F. (author)
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Valenti, L. (author)
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- Romeo, Stefano, 1976 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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(creator_code:org_t)
- Oxford University Press (OUP), 2016
- 2016
- English.
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In: Inflammatory Bowel Diseases. - : Oxford University Press (OUP). - 1078-0998. ; 22:1, s. 134-140
- Related links:
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https://academic.oup...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Background: Inflammatory bowel diseases (IBD) are characterized by chronic relapsing inflammation of the gastrointestinal tract and encompass Crohn's disease and ulcerative colitis. IBD are often associated with extraintestinal manifestations affecting multiple organs including the liver. Increased levels of serum aminotransferases, possibly related to nonalcoholic fatty liver disease, constitute one of the most frequently described IBD-related liver diseases. The PNPLA3 I148M substitution is a major common genetic determinant of hepatic fat content and progression to chronic liver disease. The aim of this study was to investigate whether carriers of PNPLA3 148M allele with IBD have higher risk of liver steatosis and increase in transaminases levels. Methods: The PNPLA3 I148M (rs738409) genotype was performed by Taqman assays in 158 individuals from Southern Italy (namely, Catanzaro cohort) and in 207 individuals from Northern Italy (namely, Milan cohort) with a definite diagnosis of IBD. Demographic and clinical data and also alanine transaminase levels were collected for both cohorts. The Catanzaro cohort underwent liver evaluation by sonography and liver stiffness and controlled attenuation parameter measurements by transient elastography. Results: Here, we show for the first time that carriers of the PNPLA3 148M allele with IBD have a greater risk of hepatic steatosis (odds ratio, 2.9, and confidence interval, 1.1-7.8), higher controlled attenuation parameter values (P = 0.029), and increased circulating alanine transaminase (P = 0.035) in the Catanzaro cohort. We further confirm the higher alanine transaminase levels in the Milan cohort (P < 0.001). Conclusions: Our results show that PNPLA3 148M carriers with IBD have higher susceptibility to hepatic steatosis and liver damage.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- PNPLA3
- inflammatory bowel disease
- liver steatosis
- ALT
- controlled attenuation parameter
- transient elastography
- i148m polymorphism
- hepatic-fibrosis
- obesity
- injury
- manifestations
- individuals
- microbiota
- rs738409
- variant
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Mancina, Roselli ...
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Spagnuolo, R.
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Milano, M.
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Brogneri, S.
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Morrone, A.
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Cosco, C.
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show more...
-
Lazzaro, V.
-
Russo, C.
-
Ferro, Y.
-
Pingitore, Piero ...
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Pujia, A.
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Montalcini, T.
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Doldo, P.
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Garieri, P.
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Piodi, L.
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Caprioli, F.
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Valenti, L.
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Romeo, Stefano, ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
- Articles in the publication
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Inflammatory Bow ...
- By the university
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University of Gothenburg