A Placebo-Controlled Trial of Obeticholic Acid in Primary Biliary Cholangitis.

• Primary biliary cholangitis (formerly called primary biliary cirrhosis) can progress to cirrhosis and death despite ursodiol therapy. Alkaline phosphatase and bilirubin levels correlate with the risk of liver transplantation or death. Obeticholic acid, a farnesoid X receptor agonist, has shown potential benefit in patients with this disease.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Gastroenterologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)

Keyword

Adult

Aged

Alkaline Phosphatase

blood

Bile Acids and Salts

blood

Bone Density

drug effects

Chenodeoxycholic Acid

adverse effects

analogs & derivatives

therapeutic use

Double-Blind Method

Female

Fibroblast Growth Factors

blood

Humans

Liver Cirrhosis

etiology

Liver Cirrhosis

Biliary

blood

complications

drug therapy

Male

Middle Aged

Pruritus

chemically induced

Publication and Content Type

ref (subject category)

art (subject category)