Neonatal herpes simplex virus type 1 brain infection affects the development of sensorimotor gating in rats.

Engel, Jörgen,1942Gothenburg University,Göteborgs universitet,Institutionen för fysiologi och farmakologi, Avdelningen för farmakologi,Institute of Physiology and Pharmacology, Dept of Pharmacology (author)

The effect of neonatal brain infection of herpes simplex virus type 1 (HSV-1) on the development of sensorimotor function in the rat was investigated using an acoustic startle paradigm. Intracerebral inoculation of HSV-1 at day 2 after birth, but not at day 4, caused a significant delay in the development of prepulse inhibition of acoustic startle. A decrease in prepulse inhibition was shown at 37, 46 and 58 days of age in these rats compared to control rats. No evidence was obtained for other behavioural dysfunctions such as differences in sensorimotor reactivity, sensorimotor response habituation, spontaneous locomotor activity, rearing activity or stereotyped behaviour. Prepulse inhibition of acoustic startle is an accepted model of sensorimotor gating in the CNS, a function which has been shown diminished in schizophrenic persons. The present results suggest that early viral infections during a neurone-susceptible period may contribute to the development of this deficit.

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Farmakologi och toxikologi hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Pharmacology and Toxicology hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Neurovetenskaper hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Neurosciences hsv//eng
Age Factors
Animals
Animals
Newborn
Body Weight
physiology
Brain
pathology
physiopathology
virology
DNA
Viral
analysis
metabolism
Disease Models
Animal
Encephalitis
Herpes Simplex
pathology
physiopathology
Female
Herpesvirus 1
Human
physiology
Motor Activity
physiology
Neural Inhibition
physiology
Neuroglia
pathology
virology
Neurons
pathology
virology
Polymerase Chain Reaction
Pregnancy
Psychomotor Performance
physiology
Rats
Rats
Sprague-Dawley
Reflex
Startle
physiology
Schizophrenia
pathology
physiopathology
virology
Survival Rate
Time Factors
Viral Load

Zhang, Jianhua,1961Gothenburg University,Göteborgs universitet,Institutionen för fysiologi och farmakologi,Institute of Physiology and Pharmacology(Swepub:gu)xzhaji (author)
Bergström, Tomas,1950Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin, Avdelningen för klinisk virologi,Institute of Laboratory Medicine, Dept of Clinical Virology(Swepub:gu)xberto (author)
Conradi, Nils,1950Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin , Avdelningen för patologi,Institute of Laboratory Medicine, Dept of Pathology (author)
Forkstam, C (author)
Liljeroth, A (author)
Svensson, Lennart,1952Gothenburg University,Göteborgs universitet,Institutionen för fysiologi och farmakologi, Avdelningen för farmakologi,Institute of Physiology and Pharmacology, Dept of Pharmacology(Swepub:gu)xsvenl (author)
Göteborgs universitetInstitutionen för fysiologi och farmakologi, Avdelningen för farmakologi (creator_code:org_t)

By the author/editor: Engel, Jörgen, 1 ...; Zhang, Jianhua, ...; Bergström, Tomas ...; Conradi, Nils, 1 ...; Forkstam, C; Liljeroth, A; show more...; Svensson, Lennar ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Pharmacology and ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Neurosciences

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