Neonatal herpes simplex virus type 1 brain infection affects the development of sensorimotor gating in rats.

• The effect of neonatal brain infection of herpes simplex virus type 1 (HSV-1) on the development of sensorimotor function in the rat was investigated using an acoustic startle paradigm. Intracerebral inoculation of HSV-1 at day 2 after birth, but not at day 4, caused a significant delay in the development of prepulse inhibition of acoustic startle. A decrease in prepulse inhibition was shown at 37, 46 and 58 days of age in these rats compared to control rats. No evidence was obtained for other behavioural dysfunctions such as differences in sensorimotor reactivity, sensorimotor response habituation, spontaneous locomotor activity, rearing activity or stereotyped behaviour. Prepulse inhibition of acoustic startle is an accepted model of sensorimotor gating in the CNS, a function which has been shown diminished in schizophrenic persons. The present results suggest that early viral infections during a neurone-susceptible period may contribute to the development of this deficit.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine (hsv//eng)

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Neurosciences (hsv//eng)

Nyckelord

Age Factors

Animals

Animals

Newborn

Body Weight

physiology

Brain

pathology

physiopathology

virology

DNA

Viral

analysis

metabolism

Disease Models

Animal

Encephalitis

Herpes Simplex

pathology

physiopathology

Female

Herpesvirus 1

Human

physiology

Motor Activity

physiology

Neural Inhibition

physiology

Neuroglia

pathology

virology

Neurons

pathology

virology

Polymerase Chain Reaction

Pregnancy

Psychomotor Performance

physiology

Rats

Rats

Sprague-Dawley

Reflex

Startle

physiology

Schizophrenia

pathology

physiopathology

virology

Survival Rate

Time Factors

Viral Load

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)