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Sökning: id:"swepub:oai:gup.ub.gu.se/243174" > Precursor B Cells I...

  • Samitas, Konstantinos,1977Gothenburg University,Göteborgs universitet,Krefting Research Centre (författare)

Precursor B Cells Increase in the Lung during Airway Allergic Inflammation: A Role for B Cell-Activating Factor

  • Artikel/kapitelEngelska2016

Förlag, utgivningsår, omfång ...

  • 2016-08-11
  • Public Library of Science (PLoS),2016

Nummerbeteckningar

  • LIBRIS-ID:oai:gup.ub.gu.se/243174
  • https://gup.ub.gu.se/publication/243174URI
  • https://doi.org/10.1371/journal.pone.0161161DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:134151738URI

Kompletterande språkuppgifter

  • Språk:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Background B cells, key cells in allergic inflammation, differentiate in the bone marrow and their precursors include pro-B, pre-B and immature B cells. Eosinophil progenitor cells increase in the lung after allergen exposure. However, the existence and possible role of B cell precursors in the lung during allergic inflammation remains elusive. A BALB/c mouse model of allergic airway inflammation was utilized to perform phenotypic and quantification analyses of pro-B and pre-B cells in the lung by flow cytometry. B cell maturation factors IL-7 and B cell-activating factor (BAFF) and their receptors (CD127 and BAFFR, BCMA, TACI, respectively) were also evaluated in the lung and serum. The effect of anti-BAFF treatment was investigated both in vivo (i.p. administration of BAFF-R-Ig fusion protein) and in vitro (colony forming cell assay). Finally, BAFF levels were examined in the bronchoalveolar lavage (BAL) of asthmatic patients and healthy controls. Precursor pro and pre-B cells increase in the lung after allergen exposure, proliferate in the lung tissue in vivo, express markers of chemotaxis (CCR10 and CXCR4) and co-stimulation (CD40, CD86) and are resistant to apoptosis (Bax). Precursor B cells express receptors for BAFF at baseline, while after allergen challenge both their ligand BAFF and the BCMA receptor expression increases in B cell precursors. Blocking BAFFR in the lung in vivo decreases eosinophils and proliferating precursor B cells. Blocking BAFFR in bone marrow cultures in vitro reduces pre-B colony formation units. BAFF is increased in the BAL of severe asthmatics. Our data support the concept of a BAFF-mediated role for B cell precursors in allergic airway inflammation.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Malmhäll, Carina,1959Gothenburg University,Göteborgs universitet,Krefting Research Centre(Swepub:gu)xmalmc (författare)
  • Rådinger, Madeleine,1967Gothenburg University,Göteborgs universitet,Krefting Research Centre(Swepub:gu)xradim (författare)
  • Ramos-Ramírez, PatriciaGothenburg University,Göteborgs universitet,Krefting Research Centre(Swepub:gu)xrampa (författare)
  • Lu, You,1982Gothenburg University,Göteborgs universitet,Krefting Research Centre(Swepub:gu)xluyow (författare)
  • Deák, Tünde,1983Gothenburg University,Göteborgs universitet,Krefting Research Centre (författare)
  • Semitekolou, M. (författare)
  • Gaga, M. (författare)
  • Sjöstrand, Margareta,1947Gothenburg University,Göteborgs universitet,Krefting Research Centre(Swepub:gu)xsjosm (författare)
  • Lötvall, Jan,1956Gothenburg University,Göteborgs universitet,Krefting Research Centre(Swepub:gu)xlotja (författare)
  • Bossios, Apostolos,1969Gothenburg University,Göteborgs universitet,Krefting Research Centre(Swepub:gu)xbosap (författare)
  • Göteborgs universitetKrefting Research Centre (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Plos One: Public Library of Science (PLoS)11:81932-6203

Internetlänk

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  • Plos One (Sök värdpublikationen i LIBRIS)

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