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Important non-disea...
Important non-disease-related determinants of exhaled nitric oxide levels in mild asthma – results from the Swedish GA2LEN study
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- Al-Shamkhi, Nasrin (author)
- Uppsala universitet,Lungmedicin och allergologi
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- Alving, Kjell (author)
- Uppsala universitet,Pediatrik
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- Dahlen, S. E. (author)
- Karolinska Institutet
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- Hedlin, G. (author)
- Karolinska Institutet
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- Middelveld, R. (author)
- Karolinska Institutet
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- Bjerg, Anders, 1982 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Univ Gothenburg, Krefting Res Ctr, Dept Internal Med & Clin Nutr, Gothenburg, Sweden.
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- Ekerljung, Linda, 1979 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Univ Gothenburg, Krefting Res Ctr, Dept Internal Med & Clin Nutr, Gothenburg, Sweden.
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- Olin, A. C. (author)
- Univ Gothenburg, Sect Occupat & Environm Med, Dept Publ Hlth & Community Med, Inst Med,Sahlgrenska Acad, Gothenburg, Sweden.
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- Sommar, Johan (author)
- Umeå universitet,Yrkes- och miljömedicin,Umea Univ, Dept Publ Hlth & Clin Med Occupat & Environm Med, Umea, Sweden.
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- Forsberg, Bertil (author)
- Umeå universitet,Yrkes- och miljömedicin,Arcum,Umea Univ, Dept Publ Hlth & Clin Med Occupat & Environm Med, Umea, Sweden.
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- Janson, Christer (author)
- Uppsala universitet,Lungmedicin och allergologi
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- Malinovschi, Andrei (author)
- Uppsala universitet,Klinisk fysiologi
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(creator_code:org_t)
- 2016-06-06
- 2016
- English.
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In: Clinical and Experimental Allergy. - : Wiley. - 0954-7894 .- 1365-2222. ; 46:9, s. 1185-1193
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Abstract
Subject headings
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- Background: Fractional exhaled nitric oxide (FeNO) has a potential clinical role in asthma management. Constitutive factors such as age, height and gender, as well as individual characteristics, such as IgE sensitization and smoking, affect the levels of FeNO in population-based studies. However, their effect on FeNO in subjects with asthma has been scarcely studied. Objective: To study the effects on FeNO of these commonly regarded determinants, as demonstrated in healthy subjects, as well as menarche age and parental smoking, in a population of asthmatics. Material and Methods: Fractional exhaled nitric oxide was measured in 557 subjects with asthma from the Swedish GA2LEN study. Allergic sensitization was assessed by skin prick tests to most common aeroallergens. Upper airway comorbidities, smoking habits, smoking exposure during childhood and hormonal status (for women) were questionnaire-assessed. Results: Male gender (P < 0.001), greater height (P < 0.001) and sensitization to both perennial allergens and pollen (P < 0.001) are related to higher FeNO levels. Current smoking (P < 0.001) and having both parents smoking during childhood, vs. having neither (P < 0.001) or only one parent smoking (P = 0.002), are related to lower FeNO. Women with menarche between 9 and 11 years of age had lower FeNO than those with menarche between 12 and 14 years of age (P = 0.03) or 15 and 17 years of age (P = 0.003). Conclusions and Clinical relevance: Interpreting FeNO levels in clinical practice is complex, and constitutional determinants, as well as smoking and IgE sensitisation, are of importance in asthmatic subjects and should be accounted for when interpreting FeNO levels. Furthermore, menarche age and parental smoking during childhood and their effects on lowering FeNO deserve further studies. © 2016 John Wiley & Sons Ltd
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Keyword
- asthma
- determinants
- exhaled nitric oxide
- GA 2 LEN
- menarche
- parental smoking
- asthma
Publication and Content Type
- ref (subject category)
- art (subject category)
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Al-Shamkhi, Nasr ...
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Alving, Kjell
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Dahlen, S. E.
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Hedlin, G.
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Middelveld, R.
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Bjerg, Anders, 1 ...
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Ekerljung, Linda ...
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Olin, A. C.
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Sommar, Johan
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Forsberg, Bertil
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Janson, Christer
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Malinovschi, And ...
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University of Gothenburg
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Umeå University
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Uppsala University
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Karolinska Institutet