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Genomewide meta-ana...
Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits
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- Teumer, A. (author)
- University of Greifswald
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- Qi, Q. (author)
- Yeshiva University,Harvard University
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- Nethander, Maria, 1980 (author)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Core Facilities, Bioinformatics,Centre for Bone and Arthritis Research,Core Facilities, Bioinformatics
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show more...
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- Aschard, H. (author)
- Harvard University,New York University,EURAC Research
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Bandinelli, S. (author)
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- Beekman, M. (author)
- Leiden University Medical Centre
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- Berndt, S. I. (author)
- National Cancer Institute, USA,Boston University
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- Bidlingmaier, M. (author)
- Ludwig-Maximilian University of Munich
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- Broer, L. (author)
- Erasmus University Medical Center
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- Cappola, A. (author)
- University of Pennsylvania
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- Ceda, G. P. (author)
- University of Parma
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- Chanock, S. (author)
- University of Greifswald
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- Chen, M. H. (author)
- Boston University,University of Parma,Parma University Hospital
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- Chen, T. C. (author)
- Boston University,National Institute on Aging, United States
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- Chen, Y. D. I. (author)
- University of California, Los Angeles
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- Chung, J. (author)
- Yeshiva University
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- Del Greco Miglianico, F. (author)
- University of Lübeck,EURAC Research
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- Eriksson, Joel (author)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
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- Ferrucci, L. (author)
- National Institute on Aging, United States,Icahn School of Medicine at Mount Sinai
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- Friedrich, N. (author)
- University of Greifswald
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- Gnewuch, C. (author)
- University of Regensburg
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- Goodarzi, M. O. (author)
- Cedars-Sinai Medical Center
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- Grarup, N. (author)
- University of Copenhagen
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- Guo, T. (author)
- Yeshiva University
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- Hammer, E. (author)
- University of Greifswald
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Hayes, R. B. (author)
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Hicks, A. A. (author)
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- Hofman, A. (author)
- Erasmus University Medical Center
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- Houwing-Duistermaat, J. J. (author)
- Leiden University Medical Centre
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- Hu, F. (author)
- Harvard University
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- Hunter, D. J. (author)
- Harvard University
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- Husemoen, L. L. (author)
- Research Centre for Prevention and Health
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- Isaacs, A. (author)
- Erasmus University Medical Center,Leiden University Medical Centre
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- Jacobs, K. B. (author)
- University of Greifswald
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- Lorentzon, Mattias, 1970 (author)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Massachusetts General Hospital,Harvard University,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
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- Jansson, John-Olov, 1954 (author)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology
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- Jehmlich, N. (author)
- University of Greifswald,Helmholtz Centre for Environmental Research (UFZ)
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- Johnson, S. (author)
- Yeshiva University
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Juul, A. (author)
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- Karlsson, Magnus (author)
- Lund University,Lunds universitet,Ortopedi - klinisk och molekylär osteoporosforskning,Forskargrupper vid Lunds universitet,Orthopedics - Clinical and Molecular Osteoporosis Research,Lund University Research Groups
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- Kilpelainen, T. O. (author)
- University of Copenhagen
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- Kovacs, P. (author)
- Leipzig University
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- Kraft, P. (author)
- Harvard University
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- Li, C. (author)
- Yeshiva University
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Linneberg, A. (author)
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- Liu, Y. (author)
- Wake Forest University
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Loos, R. J. F. (author)
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- Lorentzon, Mattias, 1970 (author)
- Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
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- Lu, Y. (author)
- Icahn School of Medicine at Mount Sinai
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- Maggio, M. (author)
- University of Washington, Seattle,Erasmus University Medical Center,Leiden University Medical Centre
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- Magi, R. (author)
- University of Oxford,University of Tartu
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Meigs, J. (author)
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- Mellström, Dan, 1945 (author)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
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- Nauck, M. (author)
- Harvard University,McGill University
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- Newman, A. B. (author)
- University of Pittsburgh
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Pollak, M. N. (author)
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- Pramstaller, P. P. (author)
- EURAC Research,University of Lübeck,Leiden University Medical Centre
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- Prokopenko, I. (author)
- Imperial College London
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Psaty, B. M. (author)
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- Reincke, M. (author)
- Ludwig-Maximilian University of Munich
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- Rimm, E. B. (author)
- Harvard University
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- Rotter, J. I. (author)
- University of California, Los Angeles
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Saint Pierre, A. (author)
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- Schurmann, C. (author)
- Icahn School of Medicine at Mount Sinai
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- Seshadri, S. (author)
- Boston University
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- Sjögren, Klara, 1970 (author)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
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Slagboom, P. E. (author)
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- Strickler, H. D. (author)
- Yeshiva University
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- Stumvoll, M. (author)
- Leipzig University
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- Suh, Y. (author)
- Guangdong Medical College,Yeshiva University
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Sun, Q. (author)
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- Zhang, C. (author)
- National Institutes of Health, United States
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- Svensson, Johan, 1964 (author)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
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Tanaka, T. (author)
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- Tare, A. (author)
- Yeshiva University
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- Tönjes, A. (author)
- Leipzig University
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- Uh, H. W. (author)
- Leiden University Medical Centre,University of Greifswald
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Van Duijn, C. M. (author)
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- van Heemst, D. (author)
- Leiden University Medical Centre
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- Vandenput, Liesbeth, 1974 (author)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
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Vasan, R. S. (author)
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- Völker, U. (author)
- University of Greifswald
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Willems, Sara M. (author)
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- Ohlsson, Claes, 1965 (author)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
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Wallaschofski, H. (author)
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- Kaplan, R. C. (author)
- Yeshiva University
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(creator_code:org_t)
- 2016-06-21
- 2016
- English.
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In: Aging Cell. - : Wiley. - 1474-9718 .- 1474-9726. ; 15:5, s. 811-824
- Related links:
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http://dx.doi.org/10... (free)
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Abstract
Subject headings
Close
- The growth hormone/insulin-like growth factor (IGF) axis can be manipulated in animal models to promote longevity, and IGF-related proteins including IGF-I and IGF-binding protein-3 (IGFBP-3) have also been implicated in risk of human diseases including cardiovascular diseases, diabetes, and cancer. Through genomewide association study of up to 30884 adults of European ancestry from 21 studies, we confirmed and extended the list of previously identified loci associated with circulating IGF-I and IGFBP-3 concentrations (IGF1, IGFBP3, GCKR, TNS3, GHSR, FOXO3, ASXL2, NUBP2/IGFALS, SORCS2, and CELSR2). Significant sex interactions, which were characterized by different genotype–phenotype associations between men and women, were found only for associations of IGFBP-3 concentrations with SNPs at the loci IGFBP3 and SORCS2. Analyses of SNPs, gene expression, and protein levels suggested that interplay between IGFBP3 and genes within the NUBP2 locus (IGFALS and HAGH) may affect circulating IGF-I and IGFBP-3 concentrations. The IGF-I-decreasing allele of SNP rs934073, which is an eQTL of ASXL2, was associated with lower adiposity and higher likelihood of survival beyond 90years. The known longevity-associated variant rs2153960 (FOXO3) was observed to be a genomewide significant SNP for IGF-I concentrations. Bioinformatics analysis suggested enrichment of putative regulatory elements among these IGF-I- and IGFBP-3-associated loci, particularly of rs646776 at CELSR2. In conclusion, this study identified several loci associated with circulating IGF-I and IGFBP-3 concentrations and provides clues to the potential role of the IGF axis in mediating effects of known (FOXO3) and novel (ASXL2) longevity-associated loci. © 2016 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
Keyword
- aging
- genomewide association study
- growth hormone axis
- IGF-I
- IGFBP-3
- longevity
Publication and Content Type
- ref (subject category)
- art (subject category)
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Aging Cell
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To the university's database
- By the author/editor
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Teumer, A.
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Qi, Q.
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Nethander, Maria ...
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Aschard, H.
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Bandinelli, S.
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Beekman, M.
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show more...
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Berndt, S. I.
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Bidlingmaier, M.
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Broer, L.
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Cappola, A.
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Ceda, G. P.
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Chanock, S.
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Chen, M. H.
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Chen, T. C.
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Chen, Y. D. I.
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Chung, J.
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Del Greco Miglia ...
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Eriksson, Joel
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Ferrucci, L.
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Friedrich, N.
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Gnewuch, C.
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Goodarzi, M. O.
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Grarup, N.
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Guo, T.
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Hammer, E.
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Hayes, R. B.
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Hicks, A. A.
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Hofman, A.
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Houwing-Duisterm ...
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Hu, F.
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Hunter, D. J.
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Husemoen, L. L.
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Isaacs, A.
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Jacobs, K. B.
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Lorentzon, Matti ...
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Jansson, John-Ol ...
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Jehmlich, N.
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Johnson, S.
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Juul, A.
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Karlsson, Magnus
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Kilpelainen, T. ...
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Kovacs, P.
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Kraft, P.
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Li, C.
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Linneberg, A.
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Liu, Y.
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Loos, R. J. F.
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Lu, Y.
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Maggio, M.
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Magi, R.
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Meigs, J.
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Mellström, Dan, ...
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Nauck, M.
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Newman, A. B.
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Pollak, M. N.
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Pramstaller, P. ...
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Prokopenko, I.
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Psaty, B. M.
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Reincke, M.
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Rimm, E. B.
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Rotter, J. I.
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Saint Pierre, A.
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Schurmann, C.
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Seshadri, S.
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Sjögren, Klara, ...
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Slagboom, P. E.
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Strickler, H. D.
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Stumvoll, M.
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Suh, Y.
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Sun, Q.
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Zhang, C.
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Svensson, Johan, ...
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Tanaka, T.
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Tare, A.
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Tönjes, A.
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Uh, H. W.
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Van Duijn, C. M.
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van Heemst, D.
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Vandenput, Liesb ...
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Vasan, R. S.
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Völker, U.
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Willems, Sara M.
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Ohlsson, Claes, ...
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Wallaschofski, H ...
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Kaplan, R. C.
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MEDICAL AND HEAL ...
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and Basic Medicine
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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Aging Cell
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University of Gothenburg
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Lund University