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Sökning: WFRF:(Amsellem Frederique) > (2017) > Gender differences ...

  • Beggiato, AnitaPasteur Institute,Hôpital universitaire Robert-Debré (författare)

Gender differences in autism spectrum disorders: Divergence among specific core symptoms.

  • Artikel/kapitelEngelska2017

Förlag, utgivningsår, omfång ...

  • 2016-11-03
  • Wiley,2017

Nummerbeteckningar

  • LIBRIS-ID:oai:gup.ub.gu.se/244896
  • https://gup.ub.gu.se/publication/244896URI
  • https://doi.org/10.1002/aur.1715DOI
  • https://lup.lub.lu.se/record/07701c08-cc3f-4fa2-8e06-06fdc79fecbaURI

Kompletterande språkuppgifter

  • Språk:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Community-based studies have consistently shown a sex ratio heavily skewed towards males in autism spectrum disorders (ASD). The factors underlying this predominance of males are largely unknown, but the way girls score on standardized categorical diagnostic tools might account for the underrecognition of ASD in girls. Despite the existence of different norms for boys and girls with ASD on several major screening tests, the algorithm of the Autism Diagnosis Interview-Revised (ADI-R) has not been reformulated. The aim of our study was to investigate which ADI-R items discriminate between males and females, and to evaluate their weighting in the final diagnosis of autism. We then conducted discriminant analysis (DA) on a sample of 594 probands including 129 females with ASD, recruited by the Paris Autism Research International Sibpair (PARIS) Study. A replication analysis was run on an independent sample of 1716 probands including 338 females with ASD, recruited through the Autism Genetics Resource Exchange (AGRE) program. Entering the raw scores for all ADI-R items as independent variables, the DA correctly classified 78.9% of males and 72.9% of females (P<0.001) in the PARIS cohort, and 72.2% of males and 68.3% of females (P<0.0001) in the AGRE cohort. Among the items extracted by the stepwise DA, four belonged to the ADI-R algorithm used for the final diagnosis of ASD. In conclusion, several items of the ADI-R that are taken into account in the diagnosis of autism significantly differentiates between males and females. The potential gender bias thus induced may participate in the underestimation of the prevalence of ASD in females. Autism Res 2016,. © 2016 International Society for Autism Research, Wiley Periodicals, Inc.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Peyre, HugoHôpital universitaire Robert-Debré (författare)
  • Maruani, AnnaPasteur Institute,Hôpital universitaire Robert-Debré (författare)
  • Scheid, IsabelleHôpital universitaire Robert-Debré,Pasteur Institute,Fondation FondaMental (författare)
  • Råstam, MariaLund University,Lunds universitet,Barn- och ungdomspsykiatri,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Utvecklingsrelaterade störningar, affektiv sjukdom och ångestsyndrom i barn- och ungdomspsykiatri,Forskargrupper vid Lunds universitet,Child and Adolescent Psychiatry,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Disorders in clinical child and adolescent psychiatry,Lund University Research Groups(Swepub:lu)med-mr_ (författare)
  • Amsellem, FrederiquePasteur Institute,Hôpital universitaire Robert-Debré (författare)
  • Gillberg, I Carina,1949University of Gothenburg,Gothenburg University,Göteborgs universitet,Gillbergcentrum,Gillberg Neuropsychiatry Centre(Swepub:gu)xgillc (författare)
  • Leboyer, MarionFondation FondaMental,Mondor Institute of Biomedical Research (Inserm U955),Henri Mondor Hospital (författare)
  • Bourgeron, ThomasParis Diderot University,Pasteur Institute(Swepub:gu)xbouth (författare)
  • Gillberg, Christopher,1950University of Gothenburg,Gothenburg University,Göteborgs universitet,Gillbergcentrum,Gillberg Neuropsychiatry Centre,University College London(Swepub:gu)xgilch (författare)
  • Delorme, RichardParis Diderot University,Hôpital universitaire Robert-Debré,Pasteur Institute,Fondation FondaMental (författare)
  • Pasteur InstituteHôpital universitaire Robert-Debré (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Autism research : official journal of the International Society for Autism Research: Wiley10:4, s. 680-6891939-38061939-3792
  • Ingår i:Autism Research: Wiley10:4, s. 680-6891939-3792

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