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Emergence and sprea...
Emergence and spread of a human-transmissible multidrug-resistant nontuberculous mycobacterium
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Bryant, J. M. (author)
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Grogono, D. M. (author)
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Rodriguez-Rincon, D. (author)
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show more...
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Everall, I. (author)
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Brown, K. P. (author)
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Moreno, P. (author)
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Verma, D. (author)
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Hill, E. (author)
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Drijkoningen, J. (author)
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Gilligan, P. (author)
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Esther, C. R. (author)
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Noone, P. G. (author)
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Giddings, O. (author)
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Bell, S. C. (author)
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Thomson, R. (author)
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Wainwright, C. E. (author)
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Coulter, C. (author)
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Pandey, S. (author)
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Wood, M. E. (author)
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Stockwell, R. E. (author)
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Ramsay, K. A. (author)
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Sherrard, L. J. (author)
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Kidd, T. J. (author)
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Jabbour, N. (author)
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Johnson, G. R. (author)
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Knibbs, L. D. (author)
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Morawska, L. (author)
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Sly, P. D. (author)
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Jones, A. (author)
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Bilton, D. (author)
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Laurenson, I. (author)
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Ruddy, M. (author)
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Bourke, S. (author)
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Bowler, Icjw (author)
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Chapman, S. J. (author)
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Clayton, A. (author)
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Cullen, M. (author)
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Dempsey, O. (author)
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Denton, M. (author)
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Desai, M. (author)
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Drew, R. J. (author)
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Edenborough, F. (author)
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Evans, J. (author)
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Folb, J. (author)
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Daniels, T. (author)
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Humphrey, H. (author)
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Isalska, B. (author)
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Jensen-Fangel, S. (author)
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- Jönsson, Bodil, 1959 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
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Jones, A. M. (author)
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Katzenstein, T. L. (author)
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Lillebaek, T. (author)
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MacGregor, G. (author)
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Mayell, S. (author)
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Millar, M. (author)
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Modha, D. (author)
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Nash, E. F. (author)
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O'Brien, C. (author)
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O'Brien, D. (author)
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Ohri, C. (author)
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Pao, C. S. (author)
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Peckham, D. (author)
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Perrin, F. (author)
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Perry, A. (author)
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Pressler, T. (author)
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Prtak, L. (author)
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Qvist, T. (author)
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Robb, A. (author)
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Rodgers, H. (author)
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Schaffer, K. (author)
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Shafi, N. (author)
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van Ingen, J. (author)
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Walshaw, M. (author)
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Watson, D. (author)
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West, N. (author)
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Whitehouse, J. (author)
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Haworth, C. S. (author)
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Harris, S. R. (author)
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Ordway, D. (author)
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Parkhill, J. (author)
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Floto, R. A. (author)
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(creator_code:org_t)
- American Association for the Advancement of Science (AAAS), 2016
- 2016
- English.
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In: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 354:6313, s. 751-757
- Related links:
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https://europepmc.or...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- Lung infections with Mycobacterium abscessus, a species of multidrug-resistant nontuberculous mycobacteria, are emerging as an important global threat to individuals with cystic fibrosis (CF), in whom M. abscessus accelerates inflammatory lung damage, leading to increased morbidity and mortality. Previously, M. abscessus was thought to be independently acquired by susceptible individuals from the environment. However, using whole-genome analysis of a global collection of clinical isolates, we show that the majority of M. abscessus infections are acquired through transmission, potentially via fomites and aerosols, of recently emerged dominant circulating clones that have spread globally. We demonstrate that these clones are associated with worse clinical outcomes, show increased virulence in cell-based and mouse infection models, and thus represent an urgent international infection challenge.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Keyword
- cystic-fibrosis center
- pseudomonas-aeruginosa
- environmental sources
- pulmonary infection
- lung-transplant
- abscessus
- disease
- prevalence
- epidemiology
- massiliense
- Science & Technology - Other Topics
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
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Science
(Search for host publication in LIBRIS)
To the university's database
- By the author/editor
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Bryant, J. M.
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Grogono, D. M.
-
Rodriguez-Rincon ...
-
Everall, I.
-
Brown, K. P.
-
Moreno, P.
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show more...
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Verma, D.
-
Hill, E.
-
Drijkoningen, J.
-
Gilligan, P.
-
Esther, C. R.
-
Noone, P. G.
-
Giddings, O.
-
Bell, S. C.
-
Thomson, R.
-
Wainwright, C. E ...
-
Coulter, C.
-
Pandey, S.
-
Wood, M. E.
-
Stockwell, R. E.
-
Ramsay, K. A.
-
Sherrard, L. J.
-
Kidd, T. J.
-
Jabbour, N.
-
Johnson, G. R.
-
Knibbs, L. D.
-
Morawska, L.
-
Sly, P. D.
-
Jones, A.
-
Bilton, D.
-
Laurenson, I.
-
Ruddy, M.
-
Bourke, S.
-
Bowler, Icjw
-
Chapman, S. J.
-
Clayton, A.
-
Cullen, M.
-
Dempsey, O.
-
Denton, M.
-
Desai, M.
-
Drew, R. J.
-
Edenborough, F.
-
Evans, J.
-
Folb, J.
-
Daniels, T.
-
Humphrey, H.
-
Isalska, B.
-
Jensen-Fangel, S ...
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Jönsson, Bodil, ...
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Jones, A. M.
-
Katzenstein, T. ...
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Lillebaek, T.
-
MacGregor, G.
-
Mayell, S.
-
Millar, M.
-
Modha, D.
-
Nash, E. F.
-
O'Brien, C.
-
O'Brien, D.
-
Ohri, C.
-
Pao, C. S.
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Peckham, D.
-
Perrin, F.
-
Perry, A.
-
Pressler, T.
-
Prtak, L.
-
Qvist, T.
-
Robb, A.
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Rodgers, H.
-
Schaffer, K.
-
Shafi, N.
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van Ingen, J.
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Walshaw, M.
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Watson, D.
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West, N.
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Whitehouse, J.
-
Haworth, C. S.
-
Harris, S. R.
-
Ordway, D.
-
Parkhill, J.
-
Floto, R. A.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Infectious Medic ...
- Articles in the publication
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Science
- By the university
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University of Gothenburg