Emergence and spread of a human-transmissible multidrug-resistant nontuberculous mycobacterium

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MARC

Bryant, J. M. (author)

Emergence and spread of a human-transmissible multidrug-resistant nontuberculous mycobacterium

Article/chapterEnglish2016

Publisher, publication year, extent ...

American Association for the Advancement of Science (AAAS),2016

Numbers

LIBRIS-ID:oai:gup.ub.gu.se/245839
https://gup.ub.gu.se/publication/245839URI
https://doi.org/10.1126/science.aaf8156DOI

Supplementary language notes

Language:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Lung infections with Mycobacterium abscessus, a species of multidrug-resistant nontuberculous mycobacteria, are emerging as an important global threat to individuals with cystic fibrosis (CF), in whom M. abscessus accelerates inflammatory lung damage, leading to increased morbidity and mortality. Previously, M. abscessus was thought to be independently acquired by susceptible individuals from the environment. However, using whole-genome analysis of a global collection of clinical isolates, we show that the majority of M. abscessus infections are acquired through transmission, potentially via fomites and aerosols, of recently emerged dominant circulating clones that have spread globally. We demonstrate that these clones are associated with worse clinical outcomes, show increased virulence in cell-based and mouse infection models, and thus represent an urgent international infection challenge.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Infektionsmedicin hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Infectious Medicine hsv//eng
cystic-fibrosis center
pseudomonas-aeruginosa
environmental sources
pulmonary infection
lung-transplant
abscessus
disease
prevalence
epidemiology
massiliense
Science & Technology - Other Topics

Added entries (persons, corporate bodies, meetings, titles ...)

Grogono, D. M. (author)
Rodriguez-Rincon, D. (author)
Everall, I. (author)
Brown, K. P. (author)
Moreno, P. (author)
Verma, D. (author)
Hill, E. (author)
Drijkoningen, J. (author)
Gilligan, P. (author)
Esther, C. R. (author)
Noone, P. G. (author)
Giddings, O. (author)
Bell, S. C. (author)
Thomson, R. (author)
Wainwright, C. E. (author)
Coulter, C. (author)
Pandey, S. (author)
Wood, M. E. (author)
Stockwell, R. E. (author)
Ramsay, K. A. (author)
Sherrard, L. J. (author)
Kidd, T. J. (author)
Jabbour, N. (author)
Johnson, G. R. (author)
Knibbs, L. D. (author)
Morawska, L. (author)
Sly, P. D. (author)
Jones, A. (author)
Bilton, D. (author)
Laurenson, I. (author)
Ruddy, M. (author)
Bourke, S. (author)
Bowler, Icjw (author)
Chapman, S. J. (author)
Clayton, A. (author)
Cullen, M. (author)
Dempsey, O. (author)
Denton, M. (author)
Desai, M. (author)
Drew, R. J. (author)
Edenborough, F. (author)
Evans, J. (author)
Folb, J. (author)
Daniels, T. (author)
Humphrey, H. (author)
Isalska, B. (author)
Jensen-Fangel, S. (author)
Jönsson, Bodil,1959Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine(Swepub:gu)xjobod (author)
Jones, A. M. (author)
Katzenstein, T. L. (author)
Lillebaek, T. (author)
MacGregor, G. (author)
Mayell, S. (author)
Millar, M. (author)
Modha, D. (author)
Nash, E. F. (author)
O'Brien, C. (author)
O'Brien, D. (author)
Ohri, C. (author)
Pao, C. S. (author)
Peckham, D. (author)
Perrin, F. (author)
Perry, A. (author)
Pressler, T. (author)
Prtak, L. (author)
Qvist, T. (author)
Robb, A. (author)
Rodgers, H. (author)
Schaffer, K. (author)
Shafi, N. (author)
van Ingen, J. (author)
Walshaw, M. (author)
Watson, D. (author)
West, N. (author)
Whitehouse, J. (author)
Haworth, C. S. (author)
Harris, S. R. (author)
Ordway, D. (author)
Parkhill, J. (author)
Floto, R. A. (author)
Göteborgs universitetInstitutionen för biomedicin, avdelningen för infektionssjukdomar (creator_code:org_t)

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In:Science: American Association for the Advancement of Science (AAAS)354:6313, s. 751-7570036-80751095-9203

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By the author/editor: Bryant, J. M.; Grogono, D. M.; Rodriguez-Rincon ...; Everall, I.; Brown, K. P.; Moreno, P.; show more...; Verma, D.; Hill, E.; Drijkoningen, J.; Gilligan, P.; Esther, C. R.; Noone, P. G.; Giddings, O.; Bell, S. C.; Thomson, R.; Wainwright, C. E ...; Coulter, C.; Pandey, S.; Wood, M. E.; Stockwell, R. E.; Ramsay, K. A.; Sherrard, L. J.; Kidd, T. J.; Jabbour, N.; Johnson, G. R.; Knibbs, L. D.; Morawska, L.; Sly, P. D.; Jones, A.; Bilton, D.; Laurenson, I.; Ruddy, M.; Bourke, S.; Bowler, Icjw; Chapman, S. J.; Clayton, A.; Cullen, M.; Dempsey, O.; Denton, M.; Desai, M.; Drew, R. J.; Edenborough, F.; Evans, J.; Folb, J.; Daniels, T.; Humphrey, H.; Isalska, B.; Jensen-Fangel, S ...; Jönsson, Bodil, ...; Jones, A. M.; Katzenstein, T. ...; Lillebaek, T.; MacGregor, G.; Mayell, S.; Millar, M.; Modha, D.; Nash, E. F.; O'Brien, C.; O'Brien, D.; Ohri, C.; Pao, C. S.; Peckham, D.; Perrin, F.; Perry, A.; Pressler, T.; Prtak, L.; Qvist, T.; Robb, A.; Rodgers, H.; Schaffer, K.; Shafi, N.; van Ingen, J.; Walshaw, M.; Watson, D.; West, N.; Whitehouse, J.; Haworth, C. S.; Harris, S. R.; Ordway, D.; Parkhill, J.; Floto, R. A.; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Infectious Medic ...

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By the university: University of Gothenburg

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