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Physiology, pathoph...
Physiology, pathophysiology and therapeutic implications of enteroendocrine control of food intake
- Article/chapterEnglish2016
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2016-10-20
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Informa UK Limited,2016
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LIBRIS-ID:oai:gup.ub.gu.se/246191
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https://gup.ub.gu.se/publication/246191URI
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https://doi.org/10.1080/17446651.2016.1245140DOI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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Introduction: With the increasing prevalence of obesity and its associated comorbidities, strides to improve treatment strategies have enhanced our understanding of the function of the gut in the regulation of food intake. The most successful intervention for obesity to date, bariatric surgery effectively manipulates enteroendocrine physiology to enhance satiety and reduce hunger. Areas covered: In the present article, we provide a detailed overview of the physiology of enteroendocrine control of food intake, and discuss its pathophysiologic correlates and therapeutic implications in both obesity and gastrointestinal disease. Expert commentary: Ongoing research in the field of nutrient sensing by L-cells, as well as understanding the role of the microbiome and bile acid signaling may facilitate the development of novel strategies to combat the rising population health threat associated with obesity. Further refinement of post-prandial satiety gut hormone based therapies, including the development of chimeric peptides exploiting the pleiotropic nature of the gut hormone response, and identification of novel methods of delivery may hold the key to optimization of therapeutic modulation of gut hormone physiology in obesity.
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Reynolds, J. V.
(author)
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le Roux, Carel WGothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för gastrokirurgisk forskning och utbildning,Institute of Clinical Sciences, Department of Gastrosurgical Research and Education(Swepub:gu)xleroc
(author)
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Docherty, Neil G.Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för gastrokirurgisk forskning och utbildning,Institute of Clinical Sciences, Department of Gastrosurgical Research and Education(Swepub:gu)xdocme
(author)
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Göteborgs universitetInstitutionen för kliniska vetenskaper, Avdelningen för gastrokirurgisk forskning och utbildning
(creator_code:org_t)
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In:Expert Review of Endocrinology & Metabolism: Informa UK Limited11:6, s. 475-4991744-66511744-8417
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