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Prenatal exposure t...
Prenatal exposure to interleukin-6 results in hypertension and alterations in the renin-angiotensin system of the rat.
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- Samuelsson, Anne-Maj, 1977 (author)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory
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- Alexanderson, Camilla, 1978 (author)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory
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- Mölne, Johan, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för patologi,Institute of Biomedicine, Department of Pathology
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- Haraldsson, Börje, 1957 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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- Hansell, Peter (author)
- Uppsala universitet,Institutionen för medicinsk cellbiologi
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- Holmäng, Agneta, 1959 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology,Wallenberglaboratoriet,Wallenberg Laboratory
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(creator_code:org_t)
- 2006-09-06
- 2006
- English.
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In: The Journal of physiology. - : Wiley. - 0022-3751. ; 575:Pt 3, s. 855-67
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Abstract
Subject headings
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- Cytokines are emerging as important in developmental processes. They may induce alterations in normal gene expression patterns, activate angiotensinogen transcription, or alter expression of the renin-angiotensin system (RAS). To determine whether prenatal exposure to interleukin-6 (IL-6) influences gene expression of the intrarenal RAS and contributes to renal dysfunction and hypertension in adulthood, we exposed female rats to IL-6 early (EIL-6 females) and late (LIL-6 females) in pregnancy and analysed blood pressure in the offspring at 5-20 weeks of age. Renal fluid and electrolyte excretion was assessed in clearance experiments, mRNA expression by real-time PCR, and protein levels by Western blot. Systolic pressure was increased at 5 weeks in IL-6 females and at 11 weeks in males. Circulatory RAS levels were increased in all IL-6 females, but angiotensin-1-converting enzyme (ACE) activity was increased only in LIL-6 females. LIL-6 males and IL-6 females showed decreased urinary flow rate and urinary sodium and potassium excretion. Dopamine excretion was decreased IL-6 females. In adult renal cortex, renin expression was increased in all IL-6 females, but angiotensinogen mRNA was increased only in LIL-6 females; AT(1) receptor (AT(1)-R) mRNA and protein levels were increased in LIL-6 females, whereas AT(2) receptor (AT(2)-R) levels were decreased in LIL-6 females and EIL-6 males. In adult renal medulla, AT(1)-R protein levels were increased in LIL-6 females, and AT(2)-R mRNA and protein levels were decreased in EIL-6 males and LIL-6 females. Prenatal IL-6 exposure may cause hypertension by altering the renal and circulatory RAS and renal fluid and electrolyte excretion, especially in females.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
Keyword
- Angiotensinogen
- biosynthesis
- genetics
- Animals
- Blood Pressure
- drug effects
- Dopamine
- urine
- Female
- Gene Expression Regulation
- Hypertension
- blood
- chemically induced
- physiopathology
- Interleukin-6
- toxicity
- Kidney
- drug effects
- metabolism
- Male
- Peptidyl-Dipeptidase A
- blood
- Pregnancy
- Prenatal Exposure Delayed Effects
- RNA
- Messenger
- biosynthesis
- Rats
- Rats
- Wistar
- Receptor
- Angiotensin
- Type 1
- biosynthesis
- genetics
- Renin
- biosynthesis
- blood
- genetics
- Renin-Angiotensin System
- Sex Factors
- Sodium
- urine
- Time Factors
- Urodynamics
- drug effects
Publication and Content Type
- ref (subject category)
- art (subject category)
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