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Monitoring of human...
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Mölne, Johan,1958Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för patologi,Institute of Biomedicine, Department of Pathology
(författare)
Monitoring of human uterus transplantation with cervical biopsies - a provisional scoring system for rejection.
- Artikel/kapitelEngelska2017
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LIBRIS-ID:oai:gup.ub.gu.se/247646
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https://gup.ub.gu.se/publication/247646URI
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https://doi.org/10.1111/ajt.14135DOI
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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Until now, absolute uterine factor infertility has been the major untreatable form of female infertility. Recently, uterus transplantation has proven to be the first successful treatment for absolute uterine factor infertility, with demonstration of live births. Here, live donation uterus transplantation was performed in nine women. 163 cervical biopsies (149 protocol, 14 follow-up) were taken to detect histopathological signs of rejection. Based on experience from animal experiments, we used a three-grade scoring system to evaluate biopsies systematically. Nine episodes of rejection were diagnosed in five patients: grade-1 in six episodes, grade-2 in two episodes and grade-3 in one episode. Treatment decisions were based on histopathology, and all rejection episodes were reversed after treatment. The biopsies were reviewed retrospectively and immunohistochemistry was performed to characterize the inflammatory infiltrates. A borderline category was introduced to avoid overtreatment of patients. Based on our review of all biopsies, we put forward a simple grading system for monitoring of rejection and to guide immunosuppressive treatment in uterus transplantation. This article is protected by copyright. All rights reserved.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Broecker, VerenaGothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för patologi,Institute of Biomedicine, Department of Pathology
(författare)
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Ekberg, Jana,1964Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Institute of Clinical Sciences, Department of Surgery(Swepub:gu)xekbja
(författare)
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Nilsson, Ola,1957Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för patologi,Institute of Biomedicine, Department of Pathology(Swepub:gu)xnilol
(författare)
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Dahm-Kähler, Pernilla,1964Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology(Swepub:gu)xdahmp
(författare)
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Brännström, Mats,1958Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology(Swepub:gu)xbrmat
(författare)
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Göteborgs universitetInstitutionen för biomedicin, avdelningen för patologi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons: Elsevier BV17:6, s. 1628-16361600-6143
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Ingår i:American Journal of Transplantation: Elsevier BV17:6, s. 1628-16361600-6135
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