Genetic Evidence for Causal Relationships Between Maternal Obesity-Related Traits and Birth Weight.

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Tyrrell, Jessica (author)

Genetic Evidence for Causal Relationships Between Maternal Obesity-Related Traits and Birth Weight.

Article/chapterEnglish2016

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American Medical Association (AMA),2016

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LIBRIS-ID:oai:gup.ub.gu.se/248530
https://gup.ub.gu.se/publication/248530URI
https://doi.org/10.1001/jama.2016.1975DOI

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Language:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Neonates born to overweight or obese women are larger and at higher risk of birth complications. Many maternal obesity-related traits are observationally associated with birth weight, but the causal nature of these associations is uncertain.To test for genetic evidence of causal associations of maternal body mass index (BMI) and related traits with birth weight.Mendelian randomization to test whether maternal BMI and obesity-related traits are potentially causally related to offspring birth weight. Data from 30,487 women in 18 studies were analyzed. Participants were of European ancestry from population- or community-based studies in Europe, North America, or Australia and were part of the Early Growth Genetics Consortium. Live, term, singleton offspring born between 1929 and 2013 were included.Genetic scores for BMI, fasting glucose level, type 2 diabetes, systolic blood pressure (SBP), triglyceride level, high-density lipoprotein cholesterol (HDL-C) level, vitamin D status, and adiponectin level.Offspring birth weight from 18 studies.Among the 30,487 newborns the mean birth weight in the various cohorts ranged from 3325 g to 3679 g. The maternal genetic score for BMI was associated with a 2-g (95% CI, 0 to 3 g) higher offspring birth weight per maternal BMI-raising allele (P=.008). The maternal genetic scores for fasting glucose and SBP were also associated with birth weight with effect sizes of 8 g (95% CI, 6 to 10 g) per glucose-raising allele (P=7×10(-14)) and -4 g (95% CI, -6 to -2 g) per SBP-raising allele (P=1×10(-5)), respectively. A 1-SD (≈4 points) genetically higher maternal BMI was associated with a 55-g higher offspring birth weight (95% CI, 17 to 93 g). A 1-SD (≈7.2 mg/dL) genetically higher maternal fasting glucose concentration was associated with 114-g higher offspring birth weight (95% CI, 80 to 147 g). However, a 1-SD (≈10 mm Hg) genetically higher maternal SBP was associated with a 208-g lower offspring birth weight (95% CI, -394 to -21 g). For BMI and fasting glucose, genetic associations were consistent with the observational associations, but for systolic blood pressure, the genetic and observational associations were in opposite directions.In this mendelian randomization study, genetically elevated maternal BMI and blood glucose levels were potentially causally associated with higher offspring birth weight, whereas genetically elevated maternal SBP was potentially causally related to lower birth weight. If replicated, these findings may have implications for counseling and managing pregnancies to avoid adverse weight-related birth outcomes.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Reproduktionsmedicin och gynekologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Obstetrics, Gynaecology and Reproductive Medicine hsv//eng
Adult
Birth Weight
genetics
Blood Glucose
genetics
Blood Pressure
genetics
Body Mass Index
Diabetes Mellitus
Type 2
genetics
European Continental Ancestry Group
Fasting
blood
Female
Genotype
Humans
Infant
Newborn
Mendelian Randomization Analysis
Obesity
blood
ethnology
genetics
Polymorphism
Single Nucleotide
Pregnancy
Triglycerides
genetics

Added entries (persons, corporate bodies, meetings, titles ...)

Richmond, Rebecca C (author)
Palmer, Tom M (author)
Feenstra, Bjarke (author)
Rangarajan, Janani (author)
Metrustry, Sarah (author)
Cavadino, Alana (author)
Paternoster, Lavinia (author)
Armstrong, Loren L (author)
De Silva, N Maneka G (author)
Wood, Andrew R (author)
Horikoshi, Momoko (author)
Geller, Frank (author)
Myhre, Ronny (author)
Bradfield, Jonathan P (author)
Kreiner-Møller, Eskil (author)
Huikari, Ville (author)
Painter, Jodie N (author)
Hottenga, Jouke-Jan (author)
Allard, Catherine (author)
Berry, Diane J (author)
Bouchard, Luigi (author)
Das, Shikta (author)
Evans, David M (author)
Hakonarson, Hakon (author)
Hayes, M Geoffrey (author)
Heikkinen, Jani (author)
Hofman, Albert (author)
Knight, Bridget (author)
Lind, Penelope A (author)
McCarthy, Mark I (author)
McMahon, George (author)
Medland, Sarah E (author)
Melbye, Mads (author)
Morris, Andrew P (author)
Nodzenski, Michael (author)
Reichetzeder, Christoph (author)
Ring, Susan M (author)
Sebert, Sylvain (author)
Sengpiel, Verena,1977Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology(Swepub:gu)xsenve (author)
Sørensen, Thorkild I A (author)
Willemsen, Gonneke (author)
de Geus, Eco J C (author)
Martin, Nicholas G (author)
Spector, Tim D (author)
Power, Christine (author)
Järvelin, Marjo-Riitta (author)
Bisgaard, Hans (author)
Grant, Struan F A (author)
Nohr, Ellen A (author)
Jaddoe, Vincent W (author)
Jacobsson, Bo,1960Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology(Swepub:gu)xjacbo (author)
Murray, Jeffrey C (author)
Hocher, Berthold (author)
Hattersley, Andrew T (author)
Scholtens, Denise M (author)
Davey Smith, George (author)
Hivert, Marie-France (author)
Felix, Janine F (author)
Hyppönen, Elina (author)
Lowe, William L (author)
Frayling, Timothy M (author)
Lawlor, Debbie A (author)
Freathy, Rachel M (author)
Göteborgs universitetInstitutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi (creator_code:org_t)

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In:JAMA: American Medical Association (AMA)315:11, s. 1129-401538-35980098-7484

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By the author/editor: Tyrrell, Jessica; Richmond, Rebecc ...; Palmer, Tom M; Feenstra, Bjarke; Rangarajan, Jana ...; Metrustry, Sarah; show more...; Cavadino, Alana; Paternoster, Lav ...; Armstrong, Loren ...; De Silva, N Mane ...; Wood, Andrew R; Horikoshi, Momok ...; Geller, Frank; Myhre, Ronny; Bradfield, Jonat ...; Kreiner-Møller, ...; Huikari, Ville; Painter, Jodie N; Hottenga, Jouke- ...; Allard, Catherin ...; Berry, Diane J; Bouchard, Luigi; Das, Shikta; Evans, David M; Hakonarson, Hako ...; Hayes, M Geoffre ...; Heikkinen, Jani; Hofman, Albert; Knight, Bridget; Lind, Penelope A; McCarthy, Mark I; McMahon, George; Medland, Sarah E; Melbye, Mads; Morris, Andrew P; Nodzenski, Micha ...; Reichetzeder, Ch ...; Ring, Susan M; Sebert, Sylvain; Sengpiel, Verena ...; Sørensen, Thorki ...; Willemsen, Gonne ...; de Geus, Eco J C; Martin, Nicholas ...; Spector, Tim D; Power, Christine; Järvelin, Marjo- ...; Bisgaard, Hans; Grant, Struan F ...; Nohr, Ellen A; Jaddoe, Vincent ...; Jacobsson, Bo, 1 ...; Murray, Jeffrey ...; Hocher, Berthold; Hattersley, Andr ...; Scholtens, Denis ...; Davey Smith, Geo ...; Hivert, Marie-Fr ...; Felix, Janine F; Hyppönen, Elina; Lowe, William L; Frayling, Timoth ...; Lawlor, Debbie A; Freathy, Rachel ...; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Obstetrics Gynae ...

Articles in the publication: JAMA

By the university: University of Gothenburg

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