APOE -ε4 modulates the association between regional amyloid deposition and cognitive performance in cognitively unimpaired middle-aged individuals

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APOE -ε4 modulates the association between regional amyloid deposition and cognitive performance in cognitively unimpaired middle-aged individuals

Brugulat-Serrat, Anna (författare): Global Brain Health Institute,Carlos III Health Institute,Hospital del Mar Medical Research Institute,Pasqual Maragall Foundation for Research on Alzheimer

Sánchez-Benavides, Gonzalo (författare): Carlos III Health Institute,Pasqual Maragall Foundation for Research on Alzheimer,Hospital del Mar Medical Research Institute

Cacciaglia, Raffaele (författare): Pasqual Maragall Foundation for Research on Alzheimer,Hospital del Mar Medical Research Institute,Carlos III Health Institute

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Salvadó, Gemma (författare): Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Pasqual Maragall Foundation for Research on Alzheimer

Shekari, Mahnaz (författare): Pompeu Fabra University,Hospital del Mar Medical Research Institute,Pasqual Maragall Foundation for Research on Alzheimer

Collij, Lyduine E. (författare): Vrije Universiteit Amsterdam

Buckley, Christopher (författare): University College London

van Berckel, Bart N.M. (författare): Vrije Universiteit Amsterdam

Perissinotti, Andrés (författare): Hospital Clínic of Barcelona,CIBER Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN)

Niñerola-Baizán, Aida (författare): CIBER Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN),Hospital Clínic of Barcelona

Milà-Alomà, Marta (författare): Hospital del Mar Medical Research Institute,Pasqual Maragall Foundation for Research on Alzheimer,Pompeu Fabra University,Carlos III Health Institute

Vilor-Tejedor, Natàlia (författare): Pasqual Maragall Foundation for Research on Alzheimer,Pompeu Fabra University,Center for Genomic Regulation (CRG)

Operto, Grégory (författare): Hospital del Mar Medical Research Institute,Pasqual Maragall Foundation for Research on Alzheimer,Carlos III Health Institute

Falcon, Carles (författare): Hospital del Mar Medical Research Institute,Pasqual Maragall Foundation for Research on Alzheimer

Grau-Rivera, Oriol (författare): Carlos III Health Institute,Hospital del Mar Medical Research Institute,Pasqual Maragall Foundation for Research on Alzheimer

Arenaza-Urquijo, Eider M. (författare): Carlos III Health Institute,Hospital del Mar Medical Research Institute,Pasqual Maragall Foundation for Research on Alzheimer

Minguillón, Carolina (författare): Carlos III Health Institute,Pasqual Maragall Foundation for Research on Alzheimer,Hospital del Mar Medical Research Institute

Fauria, Karine (författare): Carlos III Health Institute,Hospital del Mar Medical Research Institute,Pasqual Maragall Foundation for Research on Alzheimer

Molinuevo, José Luis (författare): H. Lundbeck A/S,Pasqual Maragall Foundation for Research on Alzheimer

Suárez-Calvet, Marc (författare): Carlos III Health Institute,Hospital del Mar Medical Research Institute,Pasqual Maragall Foundation for Research on Alzheimer

Gispert, Juan Domingo (författare): Pasqual Maragall Foundation for Research on Alzheimer,Hospital del Mar Medical Research Institute,CIBER Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN)

Cañas, Alba (författare)

Canals, Lidia (författare)

Iglesias, Laura (författare)

Marne, Paula (författare)

Beteta, Annabella (författare)

Deulofeu, Carme (författare)

Emilio, Maria (författare)

Cumplido, Irene (författare)

Domínguez, Ruth (författare)

Fuentes, Sherezade (författare)

Hernández, Laura (författare)

Vilanova, Marc (författare)

Solsona, Lluís (författare)

Huesa, Gema (författare)

Huguet, Jordi (författare)

Menchón, Tania (författare)

Polo, Albina (författare)

Pradas, Sandra (författare)

Sala-Vila, Aleix (författare)

Soteras, Anna (författare)

Stankeviciute, Laura (författare)

Akinci, Müge (författare)

Palpatzis, Eleni (författare)

Genius, Patricia (författare)

Rodríguez, Blanca (författare)

García, Marina (författare)

Ortiz-Romero, Paula (författare)

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(creator_code:org_t)

2023-03-01
2023
Engelska.
Ingår i: EJNMMI Research. - : Springer Science and Business Media LLC. - 2191-219X. ; 13:1

Relaterad länk:: http://dx.doi.org/10... (free); visa fler...; https://lup.lub.lu.s...; https://doi.org/10.1...; visa färre...

Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

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Purpose: To determine whether the APOE-ε4 allele modulates the relationship between regional β-amyloid (Aβ) accumulation and cognitive change in middle-aged cognitively unimpaired (CU) participants. Methods: The 352 CU participants (mean aged 61.1 [4.7] years) included completed two cognitive assessments (average interval 3.34 years), underwent [18F]flutemetamol Aβ positron emission tomography (PET), T1w magnetic resonance imaging (MRI), as well as APOE genotyping. Global and regional Aβ PET positivity was assessed across five regions-of-interest by visual reading (VR) and regional Centiloids. Linear regression models were developed to examine the interaction between regional and global Aβ PET positivity and APOE-ε4 status on longitudinal cognitive change assessed with the Preclinical Alzheimer’s Cognitive Composite (PACC), episodic memory, and executive function, after controlling for age, sex, education, cognitive baseline scores, and hippocampal volume. Results: In total, 57 participants (16.2%) were VR+ of whom 41 (71.9%) were APOE-ε4 carriers. No significant APOE-ε4*global Aβ PET interactions were associated with cognitive change for any cognitive test. However, APOE-ε4 carriers who were VR+ in temporal areas (n = 19 [9.81%], p = 0.04) and in the striatum (n = 8 [4.14%], p = 0.01) exhibited a higher decline in the PACC. The temporal areas findings were replicated when regional PET positivity was determined with Centiloid values. Regionally, VR+ in the striatum was associated with higher memory decline. As for executive function, interactions between APOE-ε4 and regional VR+ were found in temporal and parietal regions, and in the striatum. Conclusion: CU APOE-ε4 carriers with a positive Aβ PET VR in regions known to accumulate amyloid at later stages of the Alzheimer’s disease (AD) continuum exhibited a steeper cognitive decline. This work supports the contention that regional VR of Aβ PET might convey prognostic information about future cognitive decline in individuals at higher risk of developing AD. ClinicalTrials.gov Identifier: NCT02485730. Registered 20 June 2015 https://clinicaltrials.gov/ct2/show/NCT02485730 and ClinicalTrials.gov Identifier:NCT02685969. Registered 19 February 2016 https://clinicaltrials.gov/ct2/show/NCT02685969.

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Av författaren/redakt...: Brugulat-Serrat, ...; Sánchez-Benavide ...; Cacciaglia, Raff ...; Salvadó, Gemma; Shekari, Mahnaz; Collij, Lyduine ...; visa fler...; Buckley, Christo ...; van Berckel, Bar ...; Perissinotti, An ...; Niñerola-Baizán, ...; Milà-Alomà, Mart ...; Vilor-Tejedor, N ...; Operto, Grégory; Falcon, Carles; Grau-Rivera, Ori ...; Arenaza-Urquijo, ...; Minguillón, Caro ...; Fauria, Karine; Molinuevo, José ...; Suárez-Calvet, M ...; Gispert, Juan Do ...; Cañas, Alba; Canals, Lidia; Iglesias, Laura; Marne, Paula; Beteta, Annabell ...; Deulofeu, Carme; Emilio, Maria; Cumplido, Irene; Domínguez, Ruth; Fuentes, Shereza ...; Hernández, Laura; Vilanova, Marc; Solsona, Lluís; Huesa, Gema; Huguet, Jordi; Menchón, Tania; Polo, Albina; Pradas, Sandra; Sala-Vila, Aleix; Soteras, Anna; Stankeviciute, L ...; Akinci, Müge; Palpatzis, Eleni; Genius, Patricia; Rodríguez, Blanc ...; García, Marina; Ortiz-Romero, Pa ...; visa färre...

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Artiklar i publikationen: EJNMMI Research

Av lärosätet: Lunds universitet

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APOE -ε4 modulates the association between regional amyloid deposition and cognitive performance in cognitively unimpaired middle-aged individuals

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